Michael B. Foote
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View article: Supplementary Table S2 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Supplementary Table S2 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma Open
Germline mutations present in the assessed cohort of patients with appendiceal adenocarcinoma.
View article: 707 Mechanism of MLH1 inactivation predicts benefit to dual immune checkpoint blockade in mismatch repair deficient tumors
707 Mechanism of MLH1 inactivation predicts benefit to dual immune checkpoint blockade in mismatch repair deficient tumors Open
View article: Acquired High Tumor Mutational Burden and Activity of Immunotherapy after Targeted Therapy in Microsatellite Stable Colorectal Cancer
Acquired High Tumor Mutational Burden and Activity of Immunotherapy after Targeted Therapy in Microsatellite Stable Colorectal Cancer Open
Purpose: Microsatellite stable (MSS) colorectal cancers, in contrast to microsatellite instability–high colorectal cancers, have few mutations and are insensitive to immune checkpoint blockade (ICB). Colorectal cancers treated with targete…
View article: Non-synaptic Mechanism of Ocular Dominance Plasticity
Non-synaptic Mechanism of Ocular Dominance Plasticity Open
Classic experiments showing that monocular visual disruption alters synaptic connections to binocular neurons in the brain established the fundamental concept of synaptic plasticity through coincident spike time arrival. However, if the sp…
View article: Pembrolizumab and Olaparib (POLAR) Maintenance Therapy in Metastatic Pancreatic Cancer With or Without Homologous Repair Deficiency: A Biomarker Selected Phase II Trial
Pembrolizumab and Olaparib (POLAR) Maintenance Therapy in Metastatic Pancreatic Cancer With or Without Homologous Repair Deficiency: A Biomarker Selected Phase II Trial Open
The phase 2 POLAR trial evaluated maintenance pembrolizumab plus olaparib in 63 participants with metastatic pancreatic cancer with disease control on platinum-based chemotherapy. Participants were prospectively stratified into three cohor…
View article: Clonal hematopoiesis detection by simultaneous assessment of peripheral blood mononuclear cells, blood plasma, and saliva
Clonal hematopoiesis detection by simultaneous assessment of peripheral blood mononuclear cells, blood plasma, and saliva Open
View article: The role of recurrent somatic mutations that alter conserved m6A motifs in human cancer
The role of recurrent somatic mutations that alter conserved m6A motifs in human cancer Open
N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotes and plays a key role in cellular growth and development. Global changes in cellular methylated RNA and m6A-mediated transcript regulation significantly i…
View article: RETRACTED: Circulating tumor DNA status to direct adjuvant immunotherapy for mismatch repair deficient tumors
RETRACTED: Circulating tumor DNA status to direct adjuvant immunotherapy for mismatch repair deficient tumors Open
21 March, 2025. This preprint was retracted at the authors' request due to a conflict with a conference embargo policy. Authors should verify embargo policies before posting to avoid post-publication removal.
View article: Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer
Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer Open
Summary Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on appendiceal adenocarcinoma (AC),…
View article: Data from Analysis of Shared Variants between Cancer Biospecimens
Data from Analysis of Shared Variants between Cancer Biospecimens Open
Purpose:Mutational data from multiple solid and liquid biospecimens of a single patient are often integrated to track cancer evolution. However, there is no accepted framework to resolve if individual samples from the same individual share…
View article: Supplementary Methods1 from Analysis of Shared Variants between Cancer Biospecimens
Supplementary Methods1 from Analysis of Shared Variants between Cancer Biospecimens Open
Supplementary Methods
View article: Supplementary Figures and Tables1 from Analysis of Shared Variants between Cancer Biospecimens
Supplementary Figures and Tables1 from Analysis of Shared Variants between Cancer Biospecimens Open
Supplementary Figures and Supplementary Table Headings
View article: Supplementary Tables1 from Analysis of Shared Variants between Cancer Biospecimens
Supplementary Tables1 from Analysis of Shared Variants between Cancer Biospecimens Open
Supplementary Table Data
View article: Analysis of Shared Variants between Cancer Biospecimens
Analysis of Shared Variants between Cancer Biospecimens Open
Purpose: Mutational data from multiple solid and liquid biospecimens of a single patient are often integrated to track cancer evolution. However, there is no accepted framework to resolve if individual samples from the same individual shar…
View article: Supplementary Figure S1 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Figure S1 from The impact of germline alterations in appendiceal adenocarcinoma Open
Supplemental Figure 1: Appendix cancer specific survival in patients with stage IV appendiceal adenocarcinoma stratified by presence of a germline variant. Highlighted Kaplan Meier curve areas display the 95% confidence interval for the re…
View article: Supplementary Figure S1 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Figure S1 from The impact of germline alterations in appendiceal adenocarcinoma Open
Supplemental Figure 1: Appendix cancer specific survival in patients with stage IV appendiceal adenocarcinoma stratified by presence of a germline variant. Highlighted Kaplan Meier curve areas display the 95% confidence interval for the re…
View article: Supplementary Table S2 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Table S2 from The impact of germline alterations in appendiceal adenocarcinoma Open
Germline mutations present in the assessed cohort of patients with appendiceal adenocarcinoma.
View article: Supplementary Table S3 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Table S3 from The impact of germline alterations in appendiceal adenocarcinoma Open
Clinicopathologic Features of the Appendix-Specific Survival Analysis Cohort
View article: Data from The impact of germline alterations in appendiceal adenocarcinoma
Data from The impact of germline alterations in appendiceal adenocarcinoma Open
Purpose: Over 10% of assessed patients with appendiceal adenocarcinoma (AC) have a pathogenic (P) or likely pathogenic (LP) germline variant, including genes implicated in heritable gastrointestinal cancer syndromes, such as Lynch Syndrome…
View article: Supplementary Table S1 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Table S1 from The impact of germline alterations in appendiceal adenocarcinoma Open
Genes evaluated by the MSK IMPACT germline sequencing panel
View article: Supplementary Table S1 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Table S1 from The impact of germline alterations in appendiceal adenocarcinoma Open
Genes evaluated by the MSK IMPACT germline sequencing panel
View article: Supplementary Table S2 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Table S2 from The impact of germline alterations in appendiceal adenocarcinoma Open
Germline mutations present in the assessed cohort of patients with appendiceal adenocarcinoma.
View article: Supplementary Figure S2 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Figure S2 from The impact of germline alterations in appendiceal adenocarcinoma Open
Appendix cancer specific survival in patients with stage IV appendiceal adenocarcinoma stratified by presence of a germline variant in CHEK2 (n=3) or BRCA1(n=1) associated with homologous recombination deficiency (HRD). Patients with germl…
View article: Supplementary Figure S2 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Figure S2 from The impact of germline alterations in appendiceal adenocarcinoma Open
Appendix cancer specific survival in patients with stage IV appendiceal adenocarcinoma stratified by presence of a germline variant in CHEK2 (n=3) or BRCA1(n=1) associated with homologous recombination deficiency (HRD). Patients with germl…
View article: Supplementary Table S3 from The impact of germline alterations in appendiceal adenocarcinoma
Supplementary Table S3 from The impact of germline alterations in appendiceal adenocarcinoma Open
Clinicopathologic Features of the Appendix-Specific Survival Analysis Cohort
View article: Predicting response to immune checkpoint blockade therapy among mismatch repair-deficient patients using mutational signatures
Predicting response to immune checkpoint blockade therapy among mismatch repair-deficient patients using mutational signatures Open
Despite the overall efficacy of immune checkpoint blockade (ICB) for mismatch repair deficiency (MMRD) across tumor types, a sizable fraction of patients with MMRD still do not respond to ICB. We performed mutational signature analysis of …
View article: RADT-12. GENOMIC CHARACTERISTICS AND CLINICAL OUTCOMES OF STEREOTACTIC RADIOSURGERY FOR COLORECTAL CANCER BRAIN METASTASES
RADT-12. GENOMIC CHARACTERISTICS AND CLINICAL OUTCOMES OF STEREOTACTIC RADIOSURGERY FOR COLORECTAL CANCER BRAIN METASTASES Open
PURPOSE Brain metastases (BM) from colorectal cancer (CRC) portend a limited prognosis but are poorly understood, both clinically and biologically. This study defined the clinical outcomes and genomic features of CRC BM treated with stereo…
View article: Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade
Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade Open
View article: Use of Artificial Intelligence Chatbots for Cancer Treatment Information
Use of Artificial Intelligence Chatbots for Cancer Treatment Information Open
This survey study examines the performance of a large language model chatbot in providing cancer treatment recommendations that are concordant with National Comprehensive Cancer Network guidelines.
View article: Metastatic well differentiated serotonin-producing pancreatic neuroendocrine tumor with carcinoid heart disease: a case report
Metastatic well differentiated serotonin-producing pancreatic neuroendocrine tumor with carcinoid heart disease: a case report Open
Our case highlights the importance of multidisciplinary care for patients with pancreatic NETs and early identification and management of CHD. Although uncommon, serotonin-producing pancreatic NETs can present with CHD and require combinat…