Michael B. Hoffmann
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Impact of pulsed stimulation on objective and subjective visual acuity measurements in nystagmus Open
Purpose Quanz et al. (Sci Rep 14:16797, 2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA Psych…
Neither uni- nor multi-modal exercise interventions improved single- and dual-task gait performance in physically active healthy elderly – a pilot study Open
Purpose Aging is an inevitable process leading, inter alia, to the loss of muscle mass as well as the decrease in physical and cognitive function. These age-related impairments translate into a reduced gait performance and an increased ris…
Short-term effect of Transcutaneous Spinal Cord Stimulation in patients with multiple sclerosis: a randomized sham-controlled crossover study Open
Background Gait deficits and leg spasticity are frequent symptoms in Primary and Secondary Progressive Multiple Sclerosis (PPMS and SPMS). Transcutaneous spinal cord stimulation (tSCS) may alleviate these symptoms through the reduction of …
Impact of pulsed stimulation on objective and subjective visual acuity measurements in nystagmus Open
Purpose Quanz et al. (2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA Psych_Stat ). The cause…
Assessment of the effect of physical activity on intraocular pressure using a novel implanted telemetric pressure sensor Open
Background Due to technical limitations of commonly used tonometry devices, the effects of physical exercise on intraocular pressure (IOP) have never been studied during exercise. This study continuously monitored IOP variations in patient…
DTL versus skin electrodes in recording of multifocal pattern electroretinogram and multifocal photopic negative response Open
Objective To compare the photopic negative response of the multifocal ERG (mfERG PhNR ) and the multifocal pattern electroretinogram (mfPERG) using DTL electrode (E DTL ) vs skin electrode (E SKIN ) in healthy young and old adults. Methods…
View article: Invited Session I: Focusing on the Human Fovea: Plasticity and stability in human foveal pathways
Invited Session I: Focusing on the Human Fovea: Plasticity and stability in human foveal pathways Open
The fovea is highly specialised in the human retina both structurally and functionally. Although it occupies a small fraction of the retina, a great deal of neural territory is devoted to processing its outputs downstream. What happens to …
Neither uni- nor multi-modal exercise interventions improve single- and dual-task gait performance in physically active healthy elderly – a pilot study Open
Purpose: Aging is an inevitable process leading, inter alia, to the loss of muscle mass as well as the decrease in physical and cognitive function. These age-related impairments translate into a reduced gait performance and an increased ri…
Effects of multimodal and unimodal physical training interventions on visual function in glaucoma and elderly controls – a pilot study Open
Objective To investigate the effect of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma patients (GLA) and he…
Objective Visual Acuity Estimates in Amblyopia Are More Accurate With Optotype-Based P300 Than With VEP Measurements Open
This study highlights the potential of P300-based VA testing as a reliable and objective method for assessing VA in amblyopic eyes, offering a promising tool for clinical and research applications where traditional methods fall short.
Assessing Visual Crowding in Participants With Preperimetric Glaucoma Using Eye Movement and Manual Response Paradigms Open
Our findings underscore both the value and the complexity of efficiently evaluating crowding in elderly participants, including those with preperimetric glaucoma.
Rapid campimetry - a novel robust kinetic approach for visual field screening in glaucoma Open
Purpose To investigate the robustness and variability of a novel kinetic visual field (VF) screening method termed rapid campimetry (RC). Methods In RC visual field (VF) screening is enabled via kinetic-based testing on any computer (10°/4…
Scotopic and Photopic Conventional Visual Acuity and Hyperacuity – Binocular Summation Open
Binocular summation of visual acuity might serve as a clinical biomarker to monitor therapy outcome on binocular rod and cone-mediated vision.
Reproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant Open
Background Intraocular pressure (IOP) monitoring in glaucoma management is evolving with novel devices. We investigated the reproducibility of 24 hour profiles on two consecutive days and after 30 days of self-measurements via telemetric I…
Temporal-to-Nasal Macular Ganglion Cell and Inner Plexiform Layer Ratios in a Large Adult Twin Cohort: Correlations With Age and Heritability Open
Our study gives reference values for temporal-to-nasal macular GCIPL subfield ratios. Weak negative correlations with age emerged. Genetic factors may contribute to ∼20% to 23% of the variance in healthy individuals. The ratios differ acco…
Altered Perception of the Bistable Motion Quartet in Albinism Open
The strong horizontal bias observed in PWA and PWN might partly result from the horizontal nystagmus. The even stronger horizontal bias in PWA indicates that the intrahemispherical corepresentation of both visual hemifields may play an add…
Single- and Dual-Task Gait Performance in Patients With Open-Angle Glaucoma: A Cross-sectional Study Open
The minimum toe clearance might mirror disease-related changes in walking performance and might have prognostic value for assessing fall risk in glaucoma patients.
View article: Achromatopsia—Visual Cortex Stability and Plasticity in the Absence of Functional Cones
Achromatopsia—Visual Cortex Stability and Plasticity in the Absence of Functional Cones Open
Remapping of the cortical representation of the central visual field is not a general feature in achromatopsia. It is concluded that plasticity of the human primary visual cortex is less pronounced than previously assumed. A pretherapeutic…
View article: CHIASM-Net: Artificial Intelligence-Based Direct Identification of Chiasmal Abnormalities in Albinism
CHIASM-Net: Artificial Intelligence-Based Direct Identification of Chiasmal Abnormalities in Albinism Open
CHIASM-Net was demonstrated to use relevant regions of the optic chiasm for albinism detection from magnetic resonance imaging (MRI) brain anatomies. This indicates the strong potential of CNN-based approaches for visual pathway analysis a…
View article: Functional and structural readouts for early detection of retinal involvement in multiple sclerosis
Functional and structural readouts for early detection of retinal involvement in multiple sclerosis Open
Introduction The retina, a window into the brain, allows for the investigation of many disease-associated inflammatory and neurodegenerative changes affecting the central nervous system (CNS). Multiple sclerosis (MS), an autoimmune disease…
Comparison of DTL and gold cup skin electrodes for recordings of the multifocal electroretinogram Open
Objective To compare mfERG recordings with the Dawson–Trick–Litzkow (DTL) and gold cup skin electrode in healthy young and old adults and to test the sensitivity of both electrodes to age-related changes in the responses. Methods Twenty pa…
Optical Coherence Tomography as a Biomarker for Differential Diagnostics in Nystagmus: Ganglion Cell Layer Thickness Ratio Open
In albinism, with the use of optical coherence tomography (OCT), a thinning of the macular ganglion cell layer was recently reported. As a consequence, the relevant OCT measure, i.e., a reduction of the temporal/nasal ganglion cell layer t…
The retinal pigmentation pathway in human albinism: Not so black and white Open
Albinism is a pigment disorder affecting eye, skin and/or hair. Patients usually have decreased melanin in affected tissues and suffer from severe visual abnormalities, including foveal hypoplasia and chiasmal misrouting. Combining our dat…