Michael B. Mathews
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View article: From sequence to protein structure and conformational dynamics with artificial intelligence/machine learning
From sequence to protein structure and conformational dynamics with artificial intelligence/machine learning Open
The 2024 Nobel Prize in Chemistry was awarded in part for de novo protein structure prediction using AlphaFold2, an artificial intelligence/machine learning (AI/ML) model trained on vast amounts of sequence and three-dimensional structure …
View article: Generative artificial intelligence performs rudimentary structural biology modeling
Generative artificial intelligence performs rudimentary structural biology modeling Open
View article: DNA Barcoding of Fish Fauna using Mitochondrial CO1 Gene
DNA Barcoding of Fish Fauna using Mitochondrial CO1 Gene Open
This study aimed to investigate the quantitative relationships between four fish species from three genera based on molecular analyses (barcoding) of nine species from five genera utilizing the mitochondrial COI gene. Species within the sa…
View article: Generative artificial intelligence performs rudimentary structural biology modeling
Generative artificial intelligence performs rudimentary structural biology modeling Open
Natural language-based generative artificial intelligence (AI) has become increasingly prevalent in scientific research. Intriguingly, capabilities of generative pre-trained transformer (GPT) language models beyond the scope of natural lan…
View article: 249 Addressing Structural Racism Using Community Based System Dynamics
249 Addressing Structural Racism Using Community Based System Dynamics Open
OBJECTIVES/GOALS: 1. Describe method of Community Based System Dynamics. 2. Describe CBSD as used in addressing structural racism in a previously redlined community. 3. Review example causal loop diagrams and simulation models developed us…
View article: Data from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Data from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel approach to investigate the role of the eukaryotic translation initiation factor eIF5A in human cervical cancer…
View article: Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 468K, Fig. S1. Inhibition of DOHH by ciclopirox and deferiprone. Fig. S2. Cell cycle analysis. Fig. S3. Effects of CPX and DEF on cell size and morphology. Fig. S4. Effect of CPX and DEF on HeLa cell proteins analyzed by 2D gel elect…
View article: Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 74K, Table S1. Identification of drug-dependent spots.
View article: Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Figures 1 through 4 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 468K, Fig. S1. Inhibition of DOHH by ciclopirox and deferiprone. Fig. S2. Cell cycle analysis. Fig. S3. Effects of CPX and DEF on cell size and morphology. Fig. S4. Effect of CPX and DEF on HeLa cell proteins analyzed by 2D gel elect…
View article: Data from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Data from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel approach to investigate the role of the eukaryotic translation initiation factor eIF5A in human cervical cancer…
View article: Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 109K, Fig. S5. EF-P signals in target protein sequences.
View article: Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Figure 5 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 109K, Fig. S5. EF-P signals in target protein sequences.
View article: Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation Open
PDF - 74K, Table S1. Identification of drug-dependent spots.
View article: TG and<i>G&D</i>: some thoughts and reminiscences
TG and<i>G&D</i>: some thoughts and reminiscences Open
T erri and I met at Cold
Tribute to Sidney AltmanSIDNEY ALTMAN: AN EXEMPLARY SCIENTIST, TEACHER, AND FRIEND (1939–2022)SIDNEY ALTMAN'S GREATEST ACHIEVEMENTA SHORT HISTORY OF THE DISCOVERY OF THE ESSENTIAL RNA COMPONENT OF RNase PRECOLLECTIONS OF A GRADUATE STUDENT IN SIDNEY ALTMAN'S LABORATORYMEMORIES FROM THE EARLY YEARS OF THE SIDNEY ALTMAN LABORATORYTHE SPINACH CHLOROPLAST RNase P: THE FIRST PROTEIN-ONLY RNase P!SIDNEY ALTMAN: A BRIEF MEMOIRSIDNEY ALTMAN: IN MEMORIAM ET GRATITUDINEMTALES OF THE UNEXPECTED IN SIDNEY ALTMAN'S LABORATORYTO CLEAVE OR NOT TO CLEAVE, THAT IS THE QUESTIONSIDNEY ALTMAN: CHALLENGING AUTHORITY AND BEING AN ERUDITE SCHOLARTRIBUTE TO MY BELOVED MENTOR, SIDNEY ALTMANHAVING A MENTOR FOR AN ERAIN MEMORY OF PROFESSOR SIDNEY ALTMAN: INSPIRING PEOPLE TO THE FULLHALF A CENTURY WITH SIDNEY ALTMANRECOLLECTIONS OF MY FRIENDSHIP WITH SID ALTMANPERSONAL MEMORIES OF SIDNEY ALTMANA REMARKABLE CATALYSTREMEMBERING SIDNEY ALTMANSIDNEY ALTMAN—A SCIENTIFIC ODYSSEYSID ALTMAN: FRIEND, COLLEAGUE, AND GODFATHERSIDNEY ALTMAN—A REMEMBRANCERECOLLECTIONS OF MY SCIENTIFIC INTERACTIONS WITH SIDNEY ALTMANSIDNEY ALTMAN'S TIES TO CHINATARGETING RNA TO FIGHT ANTIBIOTIC-RESISTANT BACTERIASIDNEY ALTMAN: IN HIS OWN WORDS Open
View article: Richard Jackson (1940–2020) ‐ A towering presence in translation
Richard Jackson (1940–2020) ‐ A towering presence in translation Open
View article: A guide to naming human non‐coding RNA genes
A guide to naming human non‐coding RNA genes Open
View article: Protein Synthesis and Translational Control: A Historical Perspective
Protein Synthesis and Translational Control: A Historical Perspective Open
Protein synthesis and its regulation are central to all known forms of life and impinge on biological arenas as varied as agriculture, biotechnology, and medicine. Otherwise known as translation and translational control, these processes h…
View article: Principles of Translational Control
Principles of Translational Control Open
Protein synthesis involves a complex machinery comprising numerous proteins and RNAs joined by noncovalent interactions. Its function is to link long chains of amino acids into proteins with precise sequences as encoded by the genome. Regu…
View article: Translational Control in Virus-Infected Cells
Translational Control in Virus-Infected Cells Open
As obligate intracellular parasites, virus reproduction requires host cell functions. Despite variations in genome size and configuration, nucleic acid composition, and their repertoire of encoded functions, all viruses remain unconditiona…
View article: Regulation of gene expression by translation factor eIF5A: Hypusine-modified eIF5A enhances nonsense-mediated mRNA decay in human cells
Regulation of gene expression by translation factor eIF5A: Hypusine-modified eIF5A enhances nonsense-mediated mRNA decay in human cells Open
Nonsense-mediated mRNA decay (NMD) couples protein synthesis to mRNA turnover. It eliminates defective transcripts and controls the abundance of certain normal mRNAs. Our study establishes a connection between NMD and the translation facto…
View article: Evaluation of AFP expression as a predictive marker for response to anti-VEGFR-2 inhibition
Evaluation of AFP expression as a predictive marker for response to anti-VEGFR-2 inhibition Open
View article: Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial
Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial Open
ClinicalTrial.gov NCT02191657.
View article: The translation factor eIF5A and human cancer
The translation factor eIF5A and human cancer Open