Michael B. Yaffe
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View article: Supplementary Figures S1-S7 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Supplementary Figures S1-S7 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling Open
Seven Supplementary Figures and Legends
View article: Supplementary Movie S4 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Supplementary Movie S4 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling Open
Identification of paired centromeres from sister chromatids
View article: Supplementary Movie S3 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Supplementary Movie S3 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling Open
Chromatin structure in enzalutamide treated C4-2 cells
View article: Supplementary Movie S8 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Supplementary Movie S8 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling Open
Example of mitotic arrest and cell death caused by abiraterone and onvansertib
View article: Supplementary Movie S6 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Supplementary Movie S6 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling Open
Normal mitotic cell division
View article: Supplementary Movie S5 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Supplementary Movie S5 from Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling Open
Video montage comparing mitosis of vehicle control with abiraterone treated C4-2 cells
View article: A rebrand for proteasome inhibition in solid tumors via continuous hepatic artery infusion
A rebrand for proteasome inhibition in solid tumors via continuous hepatic artery infusion Open
View article: Supplementary Figure S2 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Figure S2 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Figure S2. GCN1 drives metastatic growth through activation of ATF4
View article: Supplementary Table S3 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Table S3 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
GCN1 cDNA sequence in 4964-POP and 4964-HOP cells.
View article: Supplementary Figure S3 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Figure S3 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Figure S3. IMPACT limits ATF4 activation through competitive inhibition of GCN1
View article: Supplementary Table S2 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Table S2 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Fold change in antioxidant responsive genes upon GCN1 KD in KPC cells grown at physiologic levels of glutamine
View article: Supplementary Figure S4 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Figure S4 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Figure S4. IMPACT abrogates GCN1-mediated immune cell evasion
View article: Supplementary Table S5 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Table S5 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
TRANSITE prediction of RNA binding proteins whose motifs are overrepresented in the 3’-UTR transcriptomes of GCN1 KD (SH1 and SH2) KLM1 cells.
View article: Supplementary Figure S6 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Figure S6 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Figure S6. Nuclear GCN1 stabilizes HNRNPK leading to immune escape
View article: Data from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Data from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Given the propensity of aggressive epithelial tumors to form hepatic metastases, we performed an in vivo cDNA screen using the mouse liver and KRASG12D/TP53R273H pancreatic cells that identified t…
View article: Supplementary Table S6 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Table S6 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Extent of IMPACT CpG island promoter methylation in mouse cell lines (KPC, 4964-POP, and 4964-HOP), and five human pancreatic liver metastases compared to three primary PDACs, and two normal pancreas and liver tissue.
View article: Supplementary Table S4 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Table S4 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Differential gene expression analysis by RNA-Seq of 4964-POP cells in comparison to 4964-HOP cells arranged in order of highest expression and significant p value.
View article: Supplementary Table S7 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Table S7 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
List of all reagents used in the study
View article: Supplementary Figure S1 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Figure S1 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Figure S1. A liver specific cDNA overexpression screen identifies GCN1 as a mediator of metastatic outgrowth
View article: Supplementary Figure S5 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Figure S5 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Figure S5. NK cells eliminate IMPACT-expressing tumor cells through NKG2D recognition
View article: Supplementary Figure S7 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Figure S7 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Figure S7. Expression of IMPACT is lost through genomic deletion and epigenetic silencing
View article: Supplementary Table S1 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Supplementary Table S1 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
List of all hits identified in the cDNA screen and categorized by function. cDNAs highlighted in red were identified in the 3 KB library fraction. The number of tumor lesions identifying the cDNA is given.
View article: A simple circuit to sustain intact tumor microenvironments for complex drug interrogations
A simple circuit to sustain intact tumor microenvironments for complex drug interrogations Open
SUMMARY Deep learning and large language models can integrate complex datasets to uncover biological insights that are often undetectable through conventional analyses. With application to translational cancer research, these computational…
View article: Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth Open
Given the propensity of aggressive epithelial tumors to form hepatic metastases, we performed an in vivo cDNA screen using the mouse liver and KRASG12D/TP53R273H pancreatic cells that identified the RNA-binding protein GCN1 as an integral …
View article: Complement signaling as a T-cell checkpoint in the tumor microenvironment
Complement signaling as a T-cell checkpoint in the tumor microenvironment Open
View article: An RNA damage response network mediates the lethality of 5-FU in colorectal cancer
An RNA damage response network mediates the lethality of 5-FU in colorectal cancer Open
View article: The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks
The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks Open
View article: Signal amplification by cyclic extension enables high-sensitivity single-cell mass cytometry
Signal amplification by cyclic extension enables high-sensitivity single-cell mass cytometry Open
View article: The intrinsic substrate specificity of the human tyrosine kinome
The intrinsic substrate specificity of the human tyrosine kinome Open
Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth 1 . Multicellular eukaryotes typically have more than 50 distinct protein Tyr kinases that catalyse the phosp…
View article: Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis
Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis Open
Kupffer cells are liver resident macrophages and play critical role in fatty liver disease, yet the underlying mechanisms remain unclear. Here, we show that activation of G-protein coupled receptor 3 (GPR3) in Kupffer cells stimulates glyc…