Michael Baier
YOU?
Author Swipe
View article: Therapeutic Drug Monitoring of Long-Acting Rilpivirine and Cabotegravir for Treatment of HIV-1 Infection—A Case Series of Five Patients With One Virologic Failure After Development of Two-Class Resistance
Therapeutic Drug Monitoring of Long-Acting Rilpivirine and Cabotegravir for Treatment of HIV-1 Infection—A Case Series of Five Patients With One Virologic Failure After Development of Two-Class Resistance Open
Virologic failure of long-acting rilpivirine/cabotegravir is rare but may result in severely limited treatment options. Known risk factors cannot predict all cases. Therapeutic drug monitoring (TDM) may help identify patients at risk, but …
View article: Longitudinal analysis of 20 Years of external quality assurance schemes for PCR/NAAT-based bacterial genome detection in diagnostic testing
Longitudinal analysis of 20 Years of external quality assurance schemes for PCR/NAAT-based bacterial genome detection in diagnostic testing Open
Background: Quality control (QC), quality assurance, and standardization are crucial for modern diagnostic testing in the field of medical microbiology. The need for efficient QC to ensure accurate laboratory results, treatment, and infect…
View article: COVID-19 outbreak among employees of a German hospital – risk factor analysis based on a follow-up questionnaire and seroprevalence
COVID-19 outbreak among employees of a German hospital – risk factor analysis based on a follow-up questionnaire and seroprevalence Open
The Co-FriSero study (COVID-Friedrichroda seroprevalence study) describes a COVID-19 outbreak in a German hospital with 185 beds (Friedrichroda/Thuringia) and 404 employees at the beginning of the pandemics, which was followed up with a qu…
View article: SARS-CoV-2 Testing of Emergency Department Patients Using cobas® Liat® and eazyplex® Rapid Molecular Assays
SARS-CoV-2 Testing of Emergency Department Patients Using cobas® Liat® and eazyplex® Rapid Molecular Assays Open
Rapid testing for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) of patients presenting to emergency departments (EDs) facilitates the decision for isolation on admission to hospital wards. Differences in the sensitivity of m…
View article: Non-patient-related SARS-CoV-2 exposure from colleagues and household members poses the highest infection risk for hospital employees in a German university hospital: follow-up of the prospective Co-HCW seroprevalence study
Non-patient-related SARS-CoV-2 exposure from colleagues and household members poses the highest infection risk for hospital employees in a German university hospital: follow-up of the prospective Co-HCW seroprevalence study Open
Purpose The Co-HCW study is a prospective, longitudinal, single-center observational study that aims to assess the SARS-CoV-2 seroprevalence and infection status in staff members of Jena University Hospital (JUH) in Jena, Germany. Methods …
View article: Persistent humoral and CD4+ TH cell immunity after mild SARS-COV-2 infection—The CoNAN long-term study
Persistent humoral and CD4+ TH cell immunity after mild SARS-COV-2 infection—The CoNAN long-term study Open
Understanding persistent cellular and humoral immune responses to SARS-CoV-2 will be of major importance to terminate the ongoing pandemic. Here, we assessed long-term immunity in individuals with mild COVID-19 up to 1 year after a localiz…
View article: Divergent dynamics of inflammatory mediators and multiplex PCRs during airway infection in cystic fibrosis patients and healthy controls: Serial upper airway sampling by nasal lavage
Divergent dynamics of inflammatory mediators and multiplex PCRs during airway infection in cystic fibrosis patients and healthy controls: Serial upper airway sampling by nasal lavage Open
Background In cystic fibrosis (CF), acute respiratory exacerbations critically enhance pulmonary destruction. Since these mainly occur outside regular appointments, they remain unexplored. We previously elaborated a protocol for home-based…
View article: Individualization of Mycophenolic Acid Therapy through Pharmacogenetic, Pharmacokinetic and Pharmacodynamic Testing
Individualization of Mycophenolic Acid Therapy through Pharmacogenetic, Pharmacokinetic and Pharmacodynamic Testing Open
Mycophenolic acid (MPA) is a widely used immunosuppressive agent and exerts its effect by inhibiting inosine 5′-monophosphate dehydrogenase (IMPDH), the main regulating enzyme of purine metabolism. However, significant unexplained differen…
View article: Non-patient related SARS-CoV-2 exposure to colleagues and household members impose the highest infection risk for hospital employees with and without patient contact in a German university hospital: follow-up of the prospective Co-HCW Seroprevalence study
Non-patient related SARS-CoV-2 exposure to colleagues and household members impose the highest infection risk for hospital employees with and without patient contact in a German university hospital: follow-up of the prospective Co-HCW Seroprevalence study Open
Background The Co-HCW study is a prospective, longitudinal single center observational study on the SARS-CoV-2 seroprevalence and infection status in staff members of Jena University Hospital (JUH) in Jena, Germany. Material and Methods Th…
View article: PERSISTENT IMMUNITY AFTER MILD SARS CoV-2 INFECTION - THE CoNAN-LONG TERM STUDY -
PERSISTENT IMMUNITY AFTER MILD SARS CoV-2 INFECTION - THE CoNAN-LONG TERM STUDY - Open
Objectives Understanding persistent cellular and humoral immune responses to SARS-CoV-2 will be of major importance to terminate the ongoing pandemic. Here we assessed long-term immunity in individuals with mild COVID-19 up to one year aft…
View article: Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction
Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction Open
Background: Infections, as well as adverse birth outcomes, may be more frequent in migrant women. Schistosomiasis, echinococcosis, and hepatitis E virus (HEV) seropositivity are associated with the adverse pregnancy outcomes of fetal growt…
View article: Group Vaccination Five Days before a COVID-19 Outbreak in a Long-Term Care Facility
Group Vaccination Five Days before a COVID-19 Outbreak in a Long-Term Care Facility Open
Rapid vaccination may be of benefit in long-term care facilities (LTCF) that are affected by an ongoing COVID-19 outbreak. However, there are concerns regarding the safety and effectiveness of such an approach, particularly regarding the v…
View article: Complicated Long Term Vaccine Induced Thrombotic Immune Thrombocytopenia—A Case Report
Complicated Long Term Vaccine Induced Thrombotic Immune Thrombocytopenia—A Case Report Open
Background and Objectives: Vaccine induced thrombotic thrombocytopenia (VITT) may occur after COVID-19 vaccination with recombinant adenoviral vector-based vaccines. VITT can present as cerebral sinus and venous thrombosis (CSVT), often co…
View article: Robust Neutralizing Antibody Levels Detected after Either SARS-CoV-2 Vaccination or One Year after Infection
Robust Neutralizing Antibody Levels Detected after Either SARS-CoV-2 Vaccination or One Year after Infection Open
Humoral immunity after infection or after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been attributed a key part in mitigating the further transmission of the virus. In this study, we used a commerc…
View article: One year monitoring of SARS-CoV-2 prevalence in a German cohort of patients with cystic fibrosis
One year monitoring of SARS-CoV-2 prevalence in a German cohort of patients with cystic fibrosis Open
Background: In Germany, the first case of coronavirus disease 2019 (COVID-19) was registered on 28 January 2020. By February 2021, the third wave of the pandemic began. So far, only few data are available on the SARS-CoV-2 prevalence and t…
View article: Acquired thrombotic thrombocytopenic purpura after first vaccination dose of BNT162b2 mRNA COVID-19 vaccine
Acquired thrombotic thrombocytopenic purpura after first vaccination dose of BNT162b2 mRNA COVID-19 vaccine Open
Since the survival rates of pediatric patients undergoing cancer treatment or hematopoietic stem cell transplantation (HSCT) have increased rapidly in recent decades, the late effects of treatment are now an important focus of patient care…
View article: A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients
A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients Open
To confirm discrepant SARS-CoV-2-IgG results in four standard assays we applied for the first time a prototype of a coronavirus IgG-line-blot which employs antigens from seasonal coronaviruses, SARS-1 and SARS-CoV-2 combined with avidity t…
View article: Risk Factors for Esophageal Cancer in a High-incidence Area of Malawi
Risk Factors for Esophageal Cancer in a High-incidence Area of Malawi Open
Purpose To explore associations of nutritional, infectious, and lifestyle factors with esophageal cancer (EC) occurrence in a high-risk area of Malawi. Methods This case–control study was performed with 227 patients. Data on clinicopatholo…
View article: Prospective surveillance study in a 1,400‐bed university hospital: COVID‐19 exposure at home was the main risk factor for SARS‐CoV‐2 point seroprevalence among hospital staff
Prospective surveillance study in a 1,400‐bed university hospital: COVID‐19 exposure at home was the main risk factor for SARS‐CoV‐2 point seroprevalence among hospital staff Open
The Co-HCW study is a prospective cohort study among hospital staff, including healthcare workers (HCWs) and administration staff, at the Jena University Hospital (JUH), Germany. The objectives of this study were to assess SARS-CoV-2 IgG s…
View article: Clinical evaluation of two different (1,3)‐ß‐<scp>d</scp>‐glucan assays for diagnosis of invasive fungal diseases: A retrospective cohort study
Clinical evaluation of two different (1,3)‐ß‐<span>d</span>‐glucan assays for diagnosis of invasive fungal diseases: A retrospective cohort study Open
Background Early diagnosis of invasive fungal diseases (IFDs) remains a major challenge in routine clinical practice. Objectives The aim of this retrospective cohort study was to evaluate the diagnostic performance of the fungal biomarker …