Michael Bartels
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View article: Cytoadhesion of <i>Plasmodium falciparum</i>‐Infected Red Blood Cells Changes the Expression of Cytokine‐, Histone‐ and Antiviral Protein‐Encoding Genes in Brain Endothelial Cells
Cytoadhesion of <i>Plasmodium falciparum</i>‐Infected Red Blood Cells Changes the Expression of Cytokine‐, Histone‐ and Antiviral Protein‐Encoding Genes in Brain Endothelial Cells Open
Malaria remains a significant global health problem, mainly due to Plasmodium falciparum , which is responsible for most fatal infections. Infected red blood cells (iRBCs) evade spleen clearance by adhering to endothelial cells (ECs), trig…
View article: Cytoadhesion of<i>Plasmodium falciparum</i>-infected red blood cells changes the expression of cytokine-, histone- and antiviral protein-encoding genes in brain endothelial cells
Cytoadhesion of<i>Plasmodium falciparum</i>-infected red blood cells changes the expression of cytokine-, histone- and antiviral protein-encoding genes in brain endothelial cells Open
Malaria remains a significant global health problem, mainly due to Plasmodium falciparum , which is responsible for most fatal infections. Infected red blood cells (iRBCs) evade spleen clearance by adhering to endothelial cells (ECs), trig…
View article: Approaching Thrombospondin-1 as a Potential Target for Mesenchymal Stromal Cells to Support Liver Regeneration after Partial Hepatectomy in Mouse and Humans
Approaching Thrombospondin-1 as a Potential Target for Mesenchymal Stromal Cells to Support Liver Regeneration after Partial Hepatectomy in Mouse and Humans Open
Extended liver resection carries the risk of post-surgery liver failure involving thrombospondin-1-mediated aggravation of hepatic epithelial plasticity and function. Mesenchymal stromal cells (MSCs), by interfering with thrombospondin-1 (…
View article: Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation
Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation Open
Laparoscopic liver resection (LLR) is an increasingly relevant treatment option for patients with resectable hepatocellular carcinoma (HCC). Orthotopic liver transplantation (OLT) has been considered optimal treatment for HCC in cirrhosis,…
View article: Weight of evidence analysis of the tumorigenic potential of 1,3-dichloropropene supports a threshold-based risk assessment
Weight of evidence analysis of the tumorigenic potential of 1,3-dichloropropene supports a threshold-based risk assessment Open
1,3-Dichloropropene (1,3-D; CAS #542-75-6) is a fumigant used for preplant treatment of soil to control parasitic nematodes and manage soil borne diseases for numerous fruit, vegetable, field and tree and vine crops across diverse global a…
View article: Milan criteria in the MELD era – Is it justifiable to extend the limits for orthotopic liver transplantation?
Milan criteria in the MELD era – Is it justifiable to extend the limits for orthotopic liver transplantation? Open
Background: The Milan criteria (MC) are widely used for the indication of liver transplantation (LTx) in hepatocellular carcinoma (HCC). Good long-term results have also been reported following LTx for patients exceeding the MC. In this ar…
View article: Milan criteria in the MELD era – Is it justifiable to extend the limits for orthotopic liver Transplantation?
Milan criteria in the MELD era – Is it justifiable to extend the limits for orthotopic liver Transplantation? Open
Background The Milan criteria (MC) are widely used for the indication of liver transplantation (LTx) in hepatocellular carcinoma (HCC). Good long-term results have also been reported following LTx for patients exceeding the MC. In this art…
View article: Current Treatment of Colorectal Liver Metastasis as a Chronic Disease
Current Treatment of Colorectal Liver Metastasis as a Chronic Disease Open
Currently, liver metastases from colorectal cancer are considered a chronic disease. In cases of advanced colorectal liver metastases, the definition of resectability and the indications for surgical treatment should be exclusively determi…
View article: Metabolic Basis for Nonlinearity in 1,3-Dichloropropene Toxicokinetics and Use in Setting a Kinetically-derived Maximum Inhalation Exposure Concentration in Mice
Metabolic Basis for Nonlinearity in 1,3-Dichloropropene Toxicokinetics and Use in Setting a Kinetically-derived Maximum Inhalation Exposure Concentration in Mice Open
1,3-Dichloropropene (1,3-D) showed a statistically increased incidence of bronchioloalveolar adenomas in male B6C3F1 mice at 60 ppm air concentration during previous chronic inhalation testing. No tumors were observed in female mice, nor i…
View article: Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt
Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt Open
SIC-T ads to (mostly late) complications in the interventional treatment of cirrhotic portal hypertensions and can lead to cholangitic abscesses. Patients, particularly with multiple interventions, should be screened for SIC-T.
View article: Hepatitis B Vaccination in Patients with Liver Cirrhosis Evaluated for Liver Transplantation – A Simple Intervention Ensures High Adherence
Hepatitis B Vaccination in Patients with Liver Cirrhosis Evaluated for Liver Transplantation – A Simple Intervention Ensures High Adherence Open
BACKGROUND There is an unmet need to improve the HBV vaccination status in patients with chronic liver diseases. Primary care physicians and outpatient hepatologists often fail to vaccinate as recommended. Thus, new strategies to improve t…
View article: Power of computed-tomography-defined sarcopenia for prediction of morbidity after pancreaticoduodenectomy
Power of computed-tomography-defined sarcopenia for prediction of morbidity after pancreaticoduodenectomy Open
Besides the known factors visceral obesity and narrowness of the pancreatic duct, the mean muscle attenuation can easily be examined on routine preoperative CT scans and seems to be promising parameter to predict postoperative complication…
View article: Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis
Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis Open
Summary Background Increasing evidence suggests that coffee consumption might protect against hepatocellular carcinoma (HCC) and liver cirrhosis‐associated death risk. Caffeine is a natural antagonist to extracellular adenosine and exhibit…
View article: Loss of paraspinal muscle mass is a gender‐specific consequence of cirrhosis that predicts complications and death
Loss of paraspinal muscle mass is a gender‐specific consequence of cirrhosis that predicts complications and death Open
Summary Background Loss of skeletal muscle mass is a recognised complication with a prognostic impact in patients with cirrhosis. Aim To explore in a retrospective analysis which muscle compartment most reliably predicts the occurrence of …
View article: TIE2-expressing monocytes and M2-polarized macrophages impact survival and correlate with angiogenesis in adenocarcinoma of the pancreas
TIE2-expressing monocytes and M2-polarized macrophages impact survival and correlate with angiogenesis in adenocarcinoma of the pancreas Open
Introduction: M2-polarized tumor-associated macrophages (TAMs) and TIE2- expressing monocytes (TEMs) are associated with angiogenesis and have been identified as a potential prognostic marker in several solid tumors, including hepatobiliar…
View article: Valganciclovir Prophylaxis Versus Preemptive Therapy in Cytomegalovirus-Positive Renal Allograft Recipients
Valganciclovir Prophylaxis Versus Preemptive Therapy in Cytomegalovirus-Positive Renal Allograft Recipients Open
Prophylaxis was more effective than the preemptive approach, applying a low-intense surveillance protocol in preventing CMV infection and disease in intermediate-risk patients. Both strategies were similarly effective in preventing graft l…
View article: Primary liver transplantation and liver retransplantation: comparison of health-related quality of life and mental status – a cross-sectional study
Primary liver transplantation and liver retransplantation: comparison of health-related quality of life and mental status – a cross-sectional study Open
Patients who have to undergo Re-LT procedures are faceing impairments in physical aspects of a HRQoL. Together with clinical results from other studies, the findings of the present examination underline the need for an optimized organ dist…
View article: An in vitro approach for comparative interspecies metabolism of agrochemicals
An in vitro approach for comparative interspecies metabolism of agrochemicals Open
The metabolism and elimination of a xenobiotic has a direct bearing on its potential to cause toxicity in an organism. The confidence with which data from safety studies can be extrapolated to humans depends, among other factors, upon know…
View article: Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis
Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis Open
Low plasma S1P concentrations are highly significantly associated with prognosis in end-stage liver disease. This association is independent of the stage of liver disease. Further studies should be performed to investigate S1P, its role in…