Michaël Baumann
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View article: Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC
Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC Open
View article: Deep Learning Predicts Survival Across Squamous Tumor Entities From Routine Pathology: Insights From Head and Neck, Esophagus, Lung, and Cervical Cancer
Deep Learning Predicts Survival Across Squamous Tumor Entities From Routine Pathology: Insights From Head and Neck, Esophagus, Lung, and Cervical Cancer Open
Computational pathology-based models are becoming increasingly popular for extracting biomarkers from images of cancer tissue. However, their validity is often only demonstrated on a single unseen validation cohort, limiting insights into …
View article: Accelerated vs. conventionally fractionated postoperative radiotherapy of non-small cell lung cancer—final results of the prematurely terminated PORTAF trial
Accelerated vs. conventionally fractionated postoperative radiotherapy of non-small cell lung cancer—final results of the prematurely terminated PORTAF trial Open
Purpose A prolonged overall treatment time (OTT) has been demonstrated to adversely affect the primary radiation therapy (RT) outcome in various solid tumors, including non-small cell lung cancer (NSCLC). Retrospective data from our group …
View article: The research beamlines at the Dresden proton therapy facility: available infrastructure and experimental capabilities
The research beamlines at the Dresden proton therapy facility: available infrastructure and experimental capabilities Open
The proton therapy facility in Dresden, Germany, has one treatment room equipped with a rotating gantry where patients are treated and an experimental room equipped with two horizontal beamlines for translational research. The present work…
View article: 70 | THE TRIPLE COMBINATION OF VENETOCLAX‐IBRUTINIB‐OBINUTUZUMAB PROLONGS PFS COMPARED TO VENETOCLAX‐CD20‐ANTIBODY COMBINATIONS AND CHEMOIMMUNOTHERAPY IN TREATMENT‐NAIVE CLL
70 | THE TRIPLE COMBINATION OF VENETOCLAX‐IBRUTINIB‐OBINUTUZUMAB PROLONGS PFS COMPARED TO VENETOCLAX‐CD20‐ANTIBODY COMBINATIONS AND CHEMOIMMUNOTHERAPY IN TREATMENT‐NAIVE CLL Open
View article: Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe
Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe Open
The development of new anticancer treatments, their clinical evaluation and introduction into the healthcare system need improvement. New drugs and cell therapies often come with significant costs for society while only marginally improvin…
View article: Synthetic materials with high pockels coefficient for plasmonic modulators
Synthetic materials with high pockels coefficient for plasmonic modulators Open
We present simulations of Pockels materials based on nonlinearities arising from intersubband transitions (ISBT). To elevate the Pockels coefficient to the order of nm/V, the ISBT resonance is tuned close to the operation point. This comes…
View article: Correction: Total lesion Glycolysis of primary tumor and lymphnodes is a strong predictor for development of distant metastases in oropharyngeal carcinoma patients with independent validation in automatically delineated lesions
Correction: Total lesion Glycolysis of primary tumor and lymphnodes is a strong predictor for development of distant metastases in oropharyngeal carcinoma patients with independent validation in automatically delineated lesions Open
View article: Deep Learning Predicts Survival Across Squamous Tumor Entities From H&E Stains: Insights from Head and Neck, Esophagus, Lung and Cervical Cancer
Deep Learning Predicts Survival Across Squamous Tumor Entities From H&E Stains: Insights from Head and Neck, Esophagus, Lung and Cervical Cancer Open
Computational pathology-based models are becoming increasingly popular for extracting biomarkers from images of cancer tissue. However, their validity is often only demonstrated on a single unseen validation cohort, limiting insights into …
View article: Total lesion glycolysis of primary tumor and lymphnodes is a strong predictor for development of distant metastases in oropharyngeal carcinoma patients with independent validation in automatically delineated lesions
Total lesion glycolysis of primary tumor and lymphnodes is a strong predictor for development of distant metastases in oropharyngeal carcinoma patients with independent validation in automatically delineated lesions Open
Background Oropharyngeal carcinomas are characterized by an increasing incidence and a relatively good prognosis. Nonetheless, a considerable number of patients develops metachronous distant metastases; identification of these patients is …
View article: Digital Product Passport Design Supporting the Circular Economy Based on the Asset Administration Shell
Digital Product Passport Design Supporting the Circular Economy Based on the Asset Administration Shell Open
This paper investigates the design of a digital product passport (DPP) model based on the asset administration shell (AAS) framework to support the circular economy while ensuring cross-industry applicability. In a circular economy, resour…
View article: Correction: Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic
Correction: Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic Open
View article: In memory of Univ.-Prof. Dr. med. Normann Willich (1946–2024)
In memory of Univ.-Prof. Dr. med. Normann Willich (1946–2024) Open
View article: MHz-to-THz Plasmonic Modulator
MHz-to-THz Plasmonic Modulator Open
View article: Semantic Representation of Preclinical Data in Radiation Oncology.
Semantic Representation of Preclinical Data in Radiation Oncology. Open
Background: In radiation oncology, the data generated from preclinical trials serve as initial validation for treatment effectiveness and optimizing clinical approaches by unraveling molecular mechanisms underlying different treatment resp…
View article: Supplementary Figure S3 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Figure S3 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Figure S3. (Top) Hypoxia-M V2 is associated with decreased OS in the TCGApancancer cohort (p<0.002) (Bottom) Hypoxia-M V2 is an independent prognosticator of OS (HR=1.81, p<0.03) after adjusting for demographic and clinical f…
View article: Supplementary Table S5 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S5 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S5. Distribution of clinical and biomarker-related characteristics between Methylation Hypoxia High vs Low in the validation cohort (DKTK-ROG)
View article: Supplementary Table S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S1. Multivariate Analysis for the Hypoxia-M and Brooks signature.
View article: Supplementary Table S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S1. Multivariate Analysis for the Hypoxia-M and Brooks signature.
View article: Supplementary Table S5 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S5 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S5. Distribution of clinical and biomarker-related characteristics between Methylation Hypoxia High vs Low in the validation cohort (DKTK-ROG)
View article: Supplementary Table S7 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S7 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S7. Distribution of clinical and biomarker-related characteristics between Methylation Hypoxia High vs Low in the TCGA-pancancer cohort
View article: Supplementary Methods S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Methods S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Methods, Results, Table of Contents
View article: Supplementary Table S2 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S2 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S2. Treatment Information for the validation cohort (n=88, DKTK-ROG)
View article: Supplementary Figure S4 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Figure S4 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Figure 4 (Top). CD8 T cell enrichment is prognostic for Overall Survival (OS), local recurrence (LR) and disease progression but not for distant metastasis (DM) in HPV negative HNSCC in the DKTK-ROG cohort (n=88). (Bottom) Af…
View article: Supplementary Figures S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Figures S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Figure 1. (Top) Venn Diagram showing the intersect between Hypoxia-M V2 significant DMPs (n=3397) and Hypoxia-M V1 significant DMPs (n=5129) 2551 (66%) of significant DMPs identified based on the 85th percentile of standard d…
View article: Supplementary Table S6 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S6 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S6. Contingency Table of Hypoxia-M and CD8-immunohistochemistry (IHC) staining for CD8-T cells
View article: Supplementary Table S4 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S4 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S4. Correlations with CIBERSORT immune signature expressions in the TCGA-HNSCC cohort
View article: Supplementary Table S7 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S7 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S7. Distribution of clinical and biomarker-related characteristics between Methylation Hypoxia High vs Low in the TCGA-pancancer cohort
View article: Supplementary Appendix S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Appendix S1 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Statistical Output
View article: Supplementary Table S4 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Supplementary Table S4 from DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy Open
Supplementary Table S4. Correlations with CIBERSORT immune signature expressions in the TCGA-HNSCC cohort