Michael C. Berndt
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Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor Open
Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib–IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensit…
Desialylation of <i>O</i>-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance Open
During infection neuraminidase desialylates platelets and induces their rapid clearance from circulation. The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically a…
EPHB2 regulates platelet activation Open
Historically, detailed studies of rare congenital platelet defects have provided unique insights into key proteins involved in human platelet function. In this issue of Blood, Berrou et al use advanced genomic sequencing/functional analysi…
Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment Open
Cancer-associated thrombosis is a major cause of mortality in cancer patients, the most common type being venous thromboembolism (VTE). Several risk factors for developing VTE also coexist with cancer patients, such as chemotherapy and imm…
The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance Open
Platelets have been demonstrated to be vital in cancer epithelial-mesenchymal transition (EMT), an important step in metastasis. Markers of EMT are associated with chemotherapy resistance. However, the association between the development o…
Targeting Platelets for the Treatment of Cancer Open
The majority of cancer-associated mortality results from the ability of tumour cells to metastasise leading to multifunctional organ failure and death. Disseminated tumour cells in the blood circulation are faced with major challenges such…
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function Open
The 14-3-3 family of adaptor proteins regulate diverse cellular functions including cell proliferation, metabolism, adhesion and apoptosis. Platelets express numerous 14-3-3 isoforms, including 14-3-3ζ, which has previously been implicated…
Liver-mediated shedding of platelet GPVI Open
The in vivo mechanisms underlying antibody-based shedding of the key platelet collagen receptor glycoprotein VI (GPVI) are potentially significant for future antibody-based thromboprotective agents. In this issue of Blood, Stegner et al re…