Explanipedia

Experiences of Obturator Use in Adults With Unrepaired Cleft Palate: A Qualitative Study Open

Barbara Salazar, Jonathan Diaz, M Murillo Benitez, Paulina Ocampo, Julio Recalde , et al. · 2025

In low-resource settings, adults with unrepaired cleft palate often have limited access to surgery. Palatal obturators have been proposed as an alternative to surgery in older patients. This study explored the experiences of 5 adults fitte…

A Rating Scale for Obtaining Specific, Actionable Evaluations of Nasolabial Aesthetics After Unilateral Cleft Lip Repair Open

Thomas J. Sitzman, Thomas Samson, Raymond Tse, Damir B. Matic, David M. Fisher , et al. · 2025

Background: Surgeons pursuing improvement in the aesthetic outcomes of their cleft lip repairs may benefit from a granular scale evaluating individual objectives of the repair. Methods: A working group of nine surgeons convened to develop …

Angiotensin Receptor Autoantibodies in Dupuytren Disease: A Biomarker Study Open

N. Osborne, Julia M. Harrison, David Tang, Nadim Joukhadar, Michael Bezuhly · 2025

Background: Dupuytren disease (DD) is a fibroproliferative disorder characterized by excess collagen deposition in the digitopalmar fascia resulting in disabling flexion contractures. The angiotensin II type 1 receptor (AT1R) pathway has p…

48. Silicone Taping for The Improvement of Abdominal Donor Site Scars Following Autologous Breast Reconstruction: A Randomized, Prospective Self-controlled Trial Open

Emily Burke, Julia Harrison, Emily M. Krauss, Jason G. Williams, Michael Bezuhly , et al. · 2025

Persistent glycolysis defines the foreign body response to polymeric implants Open

Christian N. Rempe, Neal I. Callaghan, Lauren Fong-Hollohan, Sarah Nersesian, Zachary S.C.S. Froom , et al. · 2025

Non-degradable polymeric implantable medical devices are a mainstay of modern healthcare but can frequently lead to severe complications. These complications are largely attributable to the foreign body response ( FBR ), which is character…

AT2R Activation Improves Wound Healing in a Preclinical Mouse Model Open

Julia M. Harrison, Edwin Leong, N. Osborne, Jean S. Marshall, Michael Bezuhly · 2024

Abnormal skin healing resulting in chronic wounds or hypertrophic scarring remains a major healthcare burden. Here, the antifibrotic angiotensin II type 2 receptor (AT2R) signaling pathway was modulated to determine its impact on cutaneous…

28. Ketotifen Inhibits Dermal Fibroblast Responses To The Pro-fibrotic Effects Of TGF-beta Open

Edwin Leong, Haya Al Bitar, Jean S. Marshall, Michael Bezuhly · 2024

Purpose: During tissue repair, dermal fibroblasts become activated, begin to differentiate, and synthesize extracellular matrix (ECM) proteins to restore tissue integrity. Transforming growth factor (TGF)-beta is a major regulator in tissu…

Ketotifen directly modifies the fibrotic response of human skin fibroblasts Open

Edwin Leong, Haya Al-Bitar, Jean S. Marshall, Michael Bezuhly · 2024

An SRF-Rearranged Malignant Cellular Myoid Neoplasm with a Novel SRF-MKL2 Fusion: A Case Report Open

Craig Erker, Cameron Crowell, Erica Schollenberg, Thai Hoa Tran, David J. Wilson , et al. · 2023

10-20% of soft tissue sarcomas cannot be accurately classified with histology and immunohistochemistry (IHC) and require further molecular investigation. We report an unclassified myoid neoplasm in a 5-year-old girl presenting with localiz…

87. Angiotensin II Type 2 Receptor Signal Modulation in Models of Cutaneous Wound Healing Open

Julia M. Harrison, Edwin Leong, Jean S. Marshall, Michael Bezuhly · 2023

PURPOSE: Globally, hypertrophic scarring remains a major burden for patients, resulting in significant aesthetic and functional morbidity. A variety of methods that target cellular pathways during wound healing have been proposed to reduce…

Sternal cleft reconstruction with acellular dermal matrix and full-thickness calvarial graft Open

Carmen Ching, Suvro Sett, Simon Walling, Michael Bezuhly · 2023

We describe reconstruction of a sternal cleft in a neonate using acellular dermal matrix, full-thickness calvarial bone graft and myocutaneous pectoralis flaps.

Comparison of two Specialized Cleft Palate Feeders Open

Cameron Penny, Kendra-Ann Nugent, Holly Gilgan, Michael Bezuhly · 2022

Objective To evaluate feeding efficiency and weight gain in infants with cleft palate fed using 1 of the 2 specialty feeders. Design Retrospective cohort study. Setting Cleft palate clinic in a tertiary pediatric hospital. Participants Inf…

“Ectopic acanthosis nigricans” in inguinal skin grafted to the hands of a child Open

Emily Burke, Ryan DeCoste, Glenda Wright, Robert B. Fraser, Noreen M. Walsh , et al. · 2022

Acanthosis nigricans (AN) is a skin disorder characterized by hyperpigmentation and hyperkeratosis and is associated with an underlying disease or condition.1 It appears as dark, coarse, thick, and velvety plaques, usually in intertriginou…

Psychosocial Distress in Parents with Children Awaiting Surgery during the COVID-19 Pandemic Open

David Forner, Patricia K. Leslie, Abdullah Aldaihani, Michael Bezuhly, Christopher W. Noel , et al. · 2022

Due to resource restrictions related to the COVID-19 pandemic, many pediatric patients are facing substantial delays for surgery, potentially resulting in additional distress for caregivers. We aimed to assess the experiences and psychosoc…

The Effect of Tongue-Tie Release on Speech Articulation and Intelligibility Open

Jonathan C. Melong, Michael Bezuhly, Paul Hong · 2021

Objective The relationship between ankyloglossia and speech is controversial. The objective of this study was to determine the effect of tongue-tie release on speech articulation and intelligibility. Methods A prospective cohort study was …

Clomiphene Citrate and Enclomiphene Hydrochloride Exposure Is Associated With Interfrontal Suture Fusion in Zebrafish Open

Tamara A. Franz‐Odendaal, Michael Bezuhly · 2021

Background: The last several decades have witnessed an increase in metopic craniosynostosis incidence. Population-based studies suggest that pharmacological exposure in utero may be responsible. This study examined effects of the fertility…

Physician Scientists of Yesterday, Today and Tomorrow — Published 44(3) September 2021 Open

Morley D. Hollenberg, Michael Bezuhly · 2021

In this issue, Ryan Kirkpatrick and Gordon Boyd speculated on the reasons for the dwindling number of physician scientists in Canada. To help stimulate discussion on this important issue, Clinical and Investigative Medicine invited two dis…

Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention Open

Edwin Leong, Michael Bezuhly, Jean S. Marshall · 2021

Systemic sclerosis (SSc) is a chronic debilitating idiopathic disorder, characterized by deposition of excessive extracellular matrix (ECM) proteins such as collagen which leads to fibrosis of the skin and other internal organs. During nor…

Oral Losartan After Limited Mandibulectomy for Treatment of Desmoid-Type Fibromatosis Open

Dennis Curry, Ahmed Alsayed, Jonathan Trites, Margaret Wheelock, Philip D. Acott , et al. · 2021

Desmoid-type fibromatosis (DF) is a rare soft tissue lesion with an annual incidence of 2 to 4 per million population and peak incidence occurring at approximately 4.5 years of age. While benign, the tumor has a locally aggressive infiltra…

Understanding families’ experiences following a diagnosis of non-syndromic craniosynostosis: a qualitative study Open

Victoria Kuta, Lauren Curry, Daniel McNeely, Simon Walling, Jill Chorney , et al. · 2020

Objectives Craniosynostosis is typically diagnosed and surgically corrected within the first year of life. The diagnosis and surgical correction of the condition can be a very stressful experience for families. Despite this, there is littl…

A Toolbox of Surgical Techniques for Palatal Fistula Repair Open

Alexis Rothermel, Jaclyn N. Lundberg, Thomas Samson, Raymond Tse, Alexander C. Allori , et al. · 2020

Objective: To provide an inventory of oronasal fistula repair techniques alongside expert commentary on which techniques are appropriate for each fistula type. Design: A 4-stage approach was used to develop a consensus on surgical techniqu…

S8A-04 SESSION 8A: METOPIC SYNOSTOSIS CLOMIPHENE CITRATE AND ENCLOMIPHENE HYDROCHLORIDE EXPOSURE IS ASSOCIATED WITH INTERFRONTAL SUTURE ABNORMALITIES IN ZEBRAFISH (DANIO RERIO) Open

Tamara A. Franz‐Odendaal, Michael Bezuhly · 2019

Introduction: Craniofacial centres have observed a dramatic increase in the incidence of metopic craniosynostosis over the last two decades. The underlying reason for this rise in incidence is unknown, but some researchers have speculated …

Effects of seasonal changes in temperature and humidity on incidence of necrotizing soft tissue infections in Halifax, Canada, 2001-2015 Open

Zahir T. Fadel, Emily Burke, Nadim Joukhadar, Osama A. Samargandi, Michael Bezuhly · 2019

This study demonstrates a tendency toward more frequent cases of NSTI with warmer, but less humid weather, without effect on severity or mortality.

Abstract QS38: Effect of Compound 21, a Selective Angiotensin II Type 2 Receptor Agonist, in an Abdominal Adhesion Murine Model Open

Colton Boudreau, Courtney Jones, Alison J. Gareau, Terry L. LeVatte, Stephanie Legere , et al. · 2019

PURPOSE: Abdominal adhesions are fibrous bands that form in response to surgical trauma, and connect visceral and/or peritoneal surfaces. Adhesions occur in over 90% of patients post-laparotomy and can lead to serious long-term complicatio…

Role of Tranexamic Acid in Reducing Intraoperative Blood Loss and Postoperative Edema and Ecchymosis in Primary Elective Rhinoplasty Open

Connor McGuire, Sean Nurmsoo, Osama A. Samargandi, Michael Bezuhly · 2019

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The effect of Steri-Strip orientation on wound healing: A survey of current applications and trends amongst surgeons Open

Yaeesh Sardiwalla, Khader Zimmo, Jason Williams, Michael Bezuhly · 2018

Wound closure strips are used in the repair of superficial, low tension wounds, lacerations, and surgical incisions.They represent an inexpensive, easy, and painless way to close such wounds or as an adjunct in a multi-layered closure. The…

Abstract: Meta-Analyses in Plastic Surgery: Can We Trust Their Results? Open

Connor McGuire, Osama A. Samargandi, Joseph P. Corkum, Helene Retrouvey, Michael Bezuhly · 2018

Abstract: Meta-Analyses in Plastic Surgery: Can We Trust Their Results? Open

Connor McGuire, Osama A. Samargandi, Joseph P. Corkum, Helene Retrouvey, Michael Bezuhly · 2018

PURPOSE: The objectives of this manuscript is to assess the overall quality of meta-analyses in plastic surgery from 2007–2017, assess whether there has been an improvement in quality over time, and evaluate variables that may be associate…

Dog Bites in Children: A Descriptive Analysis Open

Connor McGuire, Alex Morzycki, Andrew Simpson, Jason G. Williams, Michael Bezuhly · 2018

Objective: To describe characteristics of dog bites and their treatment in a pediatric population including infection, medical specialties involved, rates of admission, and need for surgery. Method: Patients presenting with a dog bite to t…

How Competitive Is Plastic Surgery? An Analysis of the Canadian and American Residency Match Open

Alexander Morzycki, Michael Bezuhly, Jason G. Williams · 2018

Background: Plastic surgery (PS) is considered to be one of the most competitive specialties. As a result, some students are discouraged from applying, reducing the overall number of PS candidates. Still, much of what we know of the match …

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