Michael Blatzer
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View article: Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice: antidepressant effects beyond the brain
Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice: antidepressant effects beyond the brain Open
Introduction Fluoxetine, the first selective serotonin reuptake inhibitor, is the world’s most prescribed antidepressant. Several mechanisms of action underpin the effect of this antidepressant, such as enhancing serotonin (5-HT) neurotran…
View article: <i>Aspergillus terreus</i> sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism
<i>Aspergillus terreus</i> sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism Open
Prolonged cultivation of certain filamentous fungi, including Aspergillus terreus , on drug-free medium leads to degeneration and morphological heterogeneity, marked by the emergence of fluffy mycelium-type sectors. This phenomenon may ind…
View article: Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice
Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice Open
View article: Using a multiomics approach to unravel a septic shock specific signature in skeletal muscle
Using a multiomics approach to unravel a septic shock specific signature in skeletal muscle Open
View article: Publisher Correction: Fungal biology: Fungal spores are future-proofed
Publisher Correction: Fungal biology: Fungal spores are future-proofed Open
View article: Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine
Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine Open
View article: Macrophages: Checking Toxicity of Fungal Metabolites in the Colon
Macrophages: Checking Toxicity of Fungal Metabolites in the Colon Open
View article: CR4 Signaling Contributes to a DC-Driven Enhanced Immune Response Against Complement-Opsonized HIV-1
CR4 Signaling Contributes to a DC-Driven Enhanced Immune Response Against Complement-Opsonized HIV-1 Open
Dendritic cells (DCs) possess intrinsic cellular defense mechanisms to specifically inhibit HIV-1 replication. In turn, HIV-1 has evolved strategies to evade innate immune sensing by DCs resulting in suboptimal maturation and poor antivira…
View article: Combined effects of exposure to engineered silver nanoparticles and the water-soluble fraction of crude oil in the marine copepod Calanus finmarchicus
Combined effects of exposure to engineered silver nanoparticles and the water-soluble fraction of crude oil in the marine copepod Calanus finmarchicus Open
While it is likely that ENPs may occur together with other contaminants in nature, the combined effects of exposure to both ENPs and environmental contaminants are not studied sufficiently. In this study, we investigated the acute and subl…
View article: Repurposing chlorpromazine to treat COVID-19: The reCoVery study
Repurposing chlorpromazine to treat COVID-19: The reCoVery study Open
View article: Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine
Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine Open
Urgent action is needed to fight the ongoing COVID-19 pandemic by reducing the number of infected people along with the infection contagiousness and severity. Chlorpromazine (CPZ), the prototype of typical antipsychotics from the phenothia…
View article: Repositionnement de la chlorpromazine dans le traitement du COVID-19 : étude reCoVery
Repositionnement de la chlorpromazine dans le traitement du COVID-19 : étude reCoVery Open
This repositioning of CPZ as an anti-SARS-CoV-2 drug offers an alternative and rapid strategy to alleviate the virus propagation and the infection severity and lethality. This CPZ repositioning strategy also avoids numerous developmental a…
View article: Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine
Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine Open
Major depressive disorder is a complex multifactorial condition with a so far poorly characterized underlying pathophysiology. Consequently, the available treatments are far from satisfactory as it is estimated that up to 30% of patients a…
View article: Plasmid-normalized quantification of relative mitochondrial DNA copy number
Plasmid-normalized quantification of relative mitochondrial DNA copy number Open
Alterations of mitochondrial DNA (mtDNA) copy number have been associated with a wide variety of phenotypes and diseases. Unfortunately, the literature provides scarce methodical information about duplex targeting of nuclear and mtDNA that…
View article: Aspergillus terreus: Novel lessons learned on amphotericin B resistance
Aspergillus terreus: Novel lessons learned on amphotericin B resistance Open
The polyene antifungal amphotericin B (AmB) exerts a powerful and broad activity against a vast array of fungi and in general displays a remarkably low rate of antimicrobial resistance. Aspergillus terreus holds an exceptional position amo…
View article: Impact of Morphological Sectors on Antifungal Susceptibility Testing and Virulence Studies
Impact of Morphological Sectors on Antifungal Susceptibility Testing and Virulence Studies Open
Morphological heterogeneity of Aspergillus terreus cultures was observed during continued cultivation of amphotericin B (AMB)-resistant isolates on drug-free medium. Outgrowth leads to the emergence of multiple sectors that might result fr…
View article: Fast-track development of an in vitro 3D lung/immune cell model to study Aspergillus infections
Fast-track development of an in vitro 3D lung/immune cell model to study Aspergillus infections Open
View article: Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance
Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance Open
In this study, we characterize the impact of antioxidative enzymes in amphotericin B (AmB)-resistant (ATR) and rare AmB-susceptible (ATS) clinical Aspergillus terreus isolates. We elucidate expression profiles of superoxide dismutase (SOD)…
View article: <i>Aspergillus fumigatus</i> responds to natural killer (NK) cells with upregulation of stress related genes and inhibits the immunoregulatory function of NK cells
<i>Aspergillus fumigatus</i> responds to natural killer (NK) cells with upregulation of stress related genes and inhibits the immunoregulatory function of NK cells Open
Natural Killer (NK) cells are active against Aspergillus fumigatus, which in turn is able to impair the host defense. Unfortunately, little is known on the mutual interaction of NK cells and A. fumigatus. We coincubated human NK cells with…
View article: Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells
Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells Open
DCs express intrinsic cellular defense mechanisms to specifically inhibit HIV-1 replication. Thus, DCs are productively infected only at very low levels with HIV-1, and this non-permissiveness of DCs is suggested to go along with viral eva…
View article: Blocking Hsp70 Enhances the Efficiency of Amphotericin B Treatment against Resistant Aspergillus terreus Strains
Blocking Hsp70 Enhances the Efficiency of Amphotericin B Treatment against Resistant Aspergillus terreus Strains Open
The polyene antifungal amphotericin B (AmB) is widely used to treat life-threatening fungal infections. Even though AmB resistance is exceptionally rare in fungi, most Aspergillus terreus isolates exhibit an intrinsic resistance against th…
View article: Differential gene expression in Aspergillus fumigatus induced by human platelets in vitro
Differential gene expression in Aspergillus fumigatus induced by human platelets in vitro Open