M. Bose
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View article: Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity
Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity Open
Spirodioxolanes were identified as a new series of direct-acting nsP2 helicase inhibitors with activity against alphaviruses. Analogs such as 6b maintained activity against viral mutants with resistance to first-generation nsP2 helicase in…
View article: Identification of Spirodioxolane nsP2 Helicase Inhibitors with Antialphaviral Activity
Identification of Spirodioxolane nsP2 Helicase Inhibitors with Antialphaviral Activity Open
We describe the design, synthesis, and antialphaviral activity of spirodioxolane inhibitors targeting the alphavirus nsP2 helicase (nsP2hel). The spirodioxolanes are a new series of direct-acting antivirals that retain key molecular featur…
View article: Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity
Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity Open
Chikungunya virus (CHIKV) replication relies on the multifunctional nsP2 protein, making it an attractive target for antiviral drug discovery. Here, we report the resolution of oxaspiropiperidine 1, a first-in-class inhibitor of the CHIKV …
View article: Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity
Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity Open
Alphaviruses are mosquito-borne RNA viruses that pose a significant public health threat, with no FDA-approved antiviral therapeutics available. The nonstructural protein 2 helicase (nsP2hel) is an enzyme involved in unwinding dsRNA essent…
View article: An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity
An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity Open
Chikungunya virus (CHIKV) replication relies on the multifunctional nsP2 protein, making it an attractive target for antiviral drug discovery. Here, we report the resolution of oxaspiropiperidine 1 , a first-in-class inhibitor of the CHIKV…
View article: Identification of Direct-acting nsP2 Helicase Inhibitors with Antialphaviral Activity
Identification of Direct-acting nsP2 Helicase Inhibitors with Antialphaviral Activity Open
Alphaviruses are mosquito-borne RNA viruses that pose a significant public health threat, with no FDA-approved antiviral therapeutics available. The non-structural protein 2 helicase (nsP2hel) is an enzyme involved in unwinding dsRNA essen…
Identification of Inhibitors of <i>Chikungunya</i> virus nsP2 ATPase Open
Non-structural protein 2 (nsP2), which plays an essential role in replication of CHIKV, contains a protease, helicase, and methyltransferase-like domain. We executed a simple a screen using malachite green to detect compounds that decrease…
PREVALENCE OF ECTOPARASITES INFESTATION AMONG SOME BREEDS OF CHICKENS IN ALQAHIRA, AKKO L. G. A, GOMBE STATE Open
Ectoparasitism has been identified as one of the major factors that threaten scavenging village chicken production systems in developing countries. The study examined the prevalence of ectoparasite infestation among chickens in Alqahira qu…