Michael Briese
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View article: Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy Open
View article: Temporal transcriptomic profiling of human three-dimensional neuromuscular co-cultures
Temporal transcriptomic profiling of human three-dimensional neuromuscular co-cultures Open
The principal organization of mammalian neuromuscular junctions (NMJs) shares essential features across species. However, human NMJs (hNMJs) exhibit distinct structural and physiological properties. While recent advances in stem-cell-based…
View article: Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease Open
View article: Proteomic analysis of isolated nerve terminals from NaV1.9 knockout mice reveals pathways relevant for pain perception
Proteomic analysis of isolated nerve terminals from NaV1.9 knockout mice reveals pathways relevant for pain perception Open
Neuropathic pain substantially affects the mental and physical well-being of patients and magnifies the socio-economic burden on the healthcare system. It is important to understand the molecular mechanisms underlying chronic pain to effec…
View article: NGF stimulation alters the transcriptome and surface TrkB expression in axons of dorsal root ganglion neurons
NGF stimulation alters the transcriptome and surface TrkB expression in axons of dorsal root ganglion neurons Open
Nerve growth factor (NGF) is released after injury from macrophages and other cell types and induces an inflammatory response in neurons, characterized by local subcellular reactions and transcriptomic modulation. NGF-induced axonal transc…
View article: Neutrophil dynamics in surgical wounds – A novel role of interleukin-7
Neutrophil dynamics in surgical wounds – A novel role of interleukin-7 Open
View article: Neuropathic Pain and Distinct CASPR2 Autoantibody IgG Subclasses Drive Neuronal Hyperexcitability
Neuropathic Pain and Distinct CASPR2 Autoantibody IgG Subclasses Drive Neuronal Hyperexcitability Open
IgG4 aAbs seem to be the major modifier of potassium channel function. The DRG hyperexcitability is primarily due to impaired Kv channel conductance as a consequence of CASPR2 aAb binding. However, additional unidentified signal pathways c…
View article: Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy
Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy Open
View article: Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability
Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability Open
Patients with autoantibodies (aAbs) against the contactin-associated protein-like 2 (CASPR2) suffer from a variety of clinical syndromes including neuropathic pain, in some patients even as the only symptom. CASPR2 is an adhesion protein o…
View article: hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis
hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis Open
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathoge…
View article: Ptbp2 re-expression rescues axon growth defects in Smn-deficient motoneurons
Ptbp2 re-expression rescues axon growth defects in Smn-deficient motoneurons Open
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations or deletions in the survival motoneuron 1 ( SMN1 ) gene, resulting in deficiency of the SMN protein that is essential for motoneuron function. Smn depletion in m…
View article: Proteomic analysis of isolated nerve terminals from Na<sub>V</sub>1.9 knockout mice reveals pathways relevant for neuropathic pain signalling
Proteomic analysis of isolated nerve terminals from Na<sub>V</sub>1.9 knockout mice reveals pathways relevant for neuropathic pain signalling Open
Neuropathic pain substantially affects the mental and physical well-being of patients and magnifies the socio-economic burden on the healthcare system. It is important to understand the molecular mechanisms underlying chronic pain to effec…
View article: hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons
hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons Open
Axonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis. The RNA-binding protein hnRNP R interacts with different motoneuron disease-related…
View article: Prevention of tau accumulation through inhibition of hnRNP R-dependent axonal<i>Mapt</i>mRNA localization
Prevention of tau accumulation through inhibition of hnRNP R-dependent axonal<i>Mapt</i>mRNA localization Open
Deposition of neurofibrillary tangles composed of hyperphosphorylated tau in the brain is a pathological hallmark and closely correlates with onset and course of Alzheimeŕs disease. While tau reduction is being pursued as therapeutic strat…
View article: Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr
Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr Open
View article: Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension
Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension Open
Chronic arterial hypertension causes cerebral microvascular dysfunction and doubles dementia risk in aging. However, cognitive health preservation by therapeutic blood pressure lowering alone is limited and depends on disease duration, the…
View article: Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy Open
Plastin 3 (PLS3) is an F-actin-bundling protein that has gained attention as a modifier of spinal muscular atrophy (SMA) pathology. SMA is a lethal pediatric neuromuscular disease caused by loss of or mutations in the Survival Motor Neuron…
View article: <scp>hnRNP</scp> R negatively regulates transcription by modulating the association of <scp>P‐TEFb</scp> with <scp>7SK</scp> and <scp>BRD4</scp>
<span>hnRNP</span> R negatively regulates transcription by modulating the association of <span>P‐TEFb</span> with <span>7SK</span> and <span>BRD4</span> Open
View article: Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin
Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin Open
Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stress. HnRNP R has a diverse range of post-transcriptional regulatory functions and is important for neuronal develop…
View article: Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function
Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function Open
The noncoding RNA 7SK is a critical regulator of transcription by adjusting the activity of the kinase complex P‐TEFb. Release of P‐TEFb from 7SK stimulates transcription at many genes by promoting productive elongation. Conversely, P‐TEFb…
View article: Publisher Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP
Publisher Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP Open
View article: Interaction of 7SK with the Smn complex modulates snRNP production
Interaction of 7SK with the Smn complex modulates snRNP production Open
View article: Author Correction: Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
Author Correction: Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice Open
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01717-x
View article: Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice Open
View article: Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function Open
View article: Author Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP
Author Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP Open
View article: Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves
Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves Open
Inflammation and dysregulation of the immune system are hallmarks of several neurodegenerative diseases. An activated immune response is considered to be the cause of myelin breakdown in demyelinating disorders. In the peripheral nervous s…
View article: R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy
R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy Open
View article: Additional file 1 of Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
Additional file 1 of Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function Open
Additional file 1: Supplementary Table 1. List of primers for cloning of shRNAs into pSIH. siRNA sequences are underlined. Supplementary Table 2. List of qPCR primers. Supplementary Table 3. List of transcripts significantly (p<0.05) upreg…
View article: A systems view of spliceosomal assembly and branchpoints with iCLIP
A systems view of spliceosomal assembly and branchpoints with iCLIP Open