Michael Bynevelt
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View article: SlicerBatchBrainMRTumorSegmentation: Automating brain tumor segmentation in 3D slicer for improved efficiency and research support
SlicerBatchBrainMRTumorSegmentation: Automating brain tumor segmentation in 3D slicer for improved efficiency and research support Open
The SlicerBatchBrainMRTumorSegmentation is a graphical user interface (GUI) based Python scripted module within 3D Slicer. Its purpose is to perform automated brain tumour segmentation for numerous patients while preserving data integrity …
Brain Connectivity, Acute Post-Concussion Symptoms, and Cognition in Adults With Concussion: A Quantitative Electroencephalography Study Open
Mild traumatic brain injury (mTBI) accounts for 80-90% of all TBI. Post-mTBI symptoms are measured using the Post-Concussion Symptom Scale (PCSS); however, symptom heterogeneity limits specificity. Better understanding of the neuropathophy…
Gliolan induced fluorescence in an isolated cerebral cryptococcoma Open
Background: Cerebral cryptococcomas can mimic high grade gliomas on magnetic resonance imaging (MRI). Under the impression of cerebral malignancy, Gliolan can be administered to facilitate fluorescence guided surgical resection of the lesi…
2294 Non-fatal cerebral artery air embolism due to pulmonary barotrauma from a pneumatocele during commercial air travel Open
Cerebral air embolism is a catastrophic phenomenon described in trauma, vascular intervention, barotrauma related to positive pressure ventilation, SCUBA diving and rarely air travel.1 A 71-year-old woman was found unrousable at the end o…
A Multicenter, Dose-Escalation, Open-Label, Phase IIa Clinical Trial to Evaluate the Safety and Efficacy of TTAC-0001 (olinvacimab), a Fully Human Monoclonal Antibody in Patients with Recurrent Glioblastoma Open
Introduction The VEGF pathway remains an important target in GBM given its vascularity and autocrine VEGF signalling. Olinvacimab is a fully humanised VEGFR2 monoclonal antibody that binds and inhibits the receptor. This report assesses th…
Incidental finding of juvenile angiofibroma from pre‐orthodontic radiographs: two case reports and a literature review Open
This case series presents two asymptomatic cases of juvenile angiofibroma which were initially incidentally identified in pre‐orthodontic radiographs. Juvenile angiofibroma is an uncommon, locally aggressive benign, vascular neoplasm with …
Efficacy of probucol on cognitive function in Alzheimer’s disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study) Open
Introduction Preclinical, clinical and epidemiological studies support the hypothesis that aberrant systemic metabolism of amyloid beta (Aβ) in the peripheral circulation is causally related to the development of Alzheimer’s disease (AD). …
Efficacy of Probucol on cognitive function in Alzheimer’s disease: Study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA Study) Open
Introduction Preclinical, clinical and epidemiological studies support the hypothesis that aberrant systemic metabolism of amyloid-beta (Aβ) in the peripheral circulation is causally related to the development of Alzheimer’s disease (AD). …
Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype Open
Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein, raising the possibility of a lipoprotein…
Hirayama disease: the importance of flexion imaging Open
Hirayama disease is a rare cervical myelopathy characterised by asymmetrical upper limb weakness and muscle atrophy in the forearm and hand. MRI of the cervical spine plays an essential role in diagnosis, however, the characteristic findin…
Predicting outcome following mild traumatic brain injury: protocol for the longitudinal, prospective, observational Concussion Recovery ( <i>CREST</i> ) cohort study Open
Introduction Mild traumatic brain injury (mTBI) is a complex injury with heterogeneous physical, cognitive, emotional and functional outcomes. Many who sustain mTBI recover within 2 weeks of injury; however, approximately 10%–20% of indivi…
CTNI-14. A 3-ARM, PHASE IIA TRIAL OF SAFETY & EFFICACY OF OLINVACIMAB, A MONOCLONAL ANTIBODY TO VEGFR2 IN PATIENTS WITH RECURRENT GLIOBLASTOMA MULTIFORME WITH IMAGING AND PK/PD ASSESSMENTS: FINAL REPORT Open
The VEGF pathway remains an important target in GBM given its vascularity and autocrine VEGF signalling. Olinvacimab (TTAC-0001) is a fully humanised VEGFR2 Mab that binds and inhibits the receptor. This report assesses the safety, dosing …
Towards the Development of an Integrative, Evidence-Based Suite of Indicators for the Prediction of Outcome Following Mild Traumatic Brain Injury: Results from a Pilot Study Open
Background: Persisting post-concussion symptoms (PPCS) is a complex, multifaceted condition in which individuals continue to experience the symptoms of mild traumatic brain injury (mTBI; concussion) beyond the timeframe that it typically t…
Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: Does the Name Require Review? Open
Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a relatively novel entity added to the revised 2016 World Health Organization classification,[1][1] though first described in 2013.[2][2] It is characterized by a cluste…
079 Glial fibrillary acidic protein (GFAP) astrocytopathy associated with cerebral micro-infarction and poor therapeutic response Open
Introduction Glial fibrillary acidic protein (GFAP) astrocytopathy is a lesser recognised immune-mediated meningo-encephalomyelitis, which is steroid responsive in the majority of cases. Neuroimaging is unique with a distinctive symmetric …
Discovering the sense of touch: protocol for a randomised controlled trial examining the efficacy of a somatosensory discrimination intervention for children with hemiplegic cerebral palsy Open
This trial is registered with the Australian New Zealand Clinical Trials Registry, registration number: ACTRN12618000348257. World Health Organisation universal trial number: U1111-1210-1726.
Additional file 1: of Discovering the sense of touch: protocol for a randomised controlled trial examining the efficacy of a somatosensory discrimination intervention for children with hemiplegic cerebral palsy Open
Treatment Fidelity Checklist. (XLSX 22 kb)
Nocturnal oxyhemoglobin desaturation and arteriopathy in a pediatric sickle cell disease cohort Open
Low nocturnal SpO2 and reticulocytosis are associated with intracranial arteriopathy in children with SCD. Preventative strategies might reduce stroke risk.
Transcriptome-wide effects of a<i>POLR3A</i>gene mutation in patients with an unusual phenotype of striatal involvement Open
RNA polymerase III is essential for the transcription of non-coding RNAs, including tRNAs. Mutations in the genes encoding its largest subunits are known to cause hypomyelinating leukodystrophies (HLD7) with pathogenetic mechanisms hypothe…
Functional magnetic resonance imaging evaluation of lumbosacral radiculopathic pain Open
OBJECTIVE An objective biomarker for pain is yet to be established. Functional MRI (fMRI) is a promising neuroimaging technique that may reveal an objective radiological biomarker. The purpose of this study was to evaluate fMRI technology …