Michael C. McAlpine
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View article: 3D printed anisotropic tissue simulants with embedded fluid capsules for medical simulation and training
3D printed anisotropic tissue simulants with embedded fluid capsules for medical simulation and training Open
Human tissues are primarily composed of collagen and elastin fiber networks that exhibit directional mechanical properties that are not replicable by conventional tissue simulants manufactured via casting. Here, we 3D print tissue simulant…
View article: 3D‐Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury
3D‐Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury Open
The transplantation of regionally specific spinal neural progenitor cells (sNPCs) has shown promise for functional restoration after spinal cord injury (SCI) by forming connections with host neural circuits. Here, 3D‐printed organoid scaff…
View article: Combined Therapeutic Strategies for Chronic Spinal Cord Injury in Rodents: Scaffold Supported Regionally Specific Human Neural Stem/Progenitor Cells with and without Electrical Stimulation
Combined Therapeutic Strategies for Chronic Spinal Cord Injury in Rodents: Scaffold Supported Regionally Specific Human Neural Stem/Progenitor Cells with and without Electrical Stimulation Open
Spinal cord injury (SCI) is a devastating event that frequently becomes a chronic condition. The consequences of neurological damage are multifaceted, with no effective clinical treatments. The majority of rodent studies have been conducte…
View article: 3D Printed Organisms Enabled by Aspiration‐Assisted Adaptive Strategies
3D Printed Organisms Enabled by Aspiration‐Assisted Adaptive Strategies Open
Devising an approach to deterministically position organisms can impact various fields such as bioimaging, cybernetics, cryopreservation, and organism‐integrated devices. This requires continuously assessing the locations of randomly distr…
View article: 3D printed microfluidics: advances in strategies, integration, and applications
3D printed microfluidics: advances in strategies, integration, and applications Open
3D printed microfluidics is a rapidly developing field promising 3D devices, autonomous integration, multifunctional platforms, and novel applications. We review the recent progress in methodologies and applications for 3D printed microflu…
View article: A Bionic Testbed for Cardiac Ablation Tools
A Bionic Testbed for Cardiac Ablation Tools Open
Bionic-engineered tissues have been proposed for testing the performance of cardiovascular medical devices and predicting clinical outcomes ex vivo. Progress has been made in the development of compliant electronics that are capable of mon…
View article: 3D Printed Skin‐Interfaced UV‐Visible Hybrid Photodetectors
3D Printed Skin‐Interfaced UV‐Visible Hybrid Photodetectors Open
Photodetectors that are intimately interfaced with human skin and measure real‐time optical irradiance are appealing in the medical profiling of photosensitive diseases. Developing compliant devices for this purpose requires the fabricatio…
View article: 3D-printed flexible organic light-emitting diode displays
3D-printed flexible organic light-emitting diode displays Open
OLED arrays were fully 3D-printed under ambient conditions to produce a flexible information display technology.
View article: The 2021 flexible and printed electronics roadmap
The 2021 flexible and printed electronics roadmap Open
This roadmap includes the perspectives and visions of leading researchers in the key areas of flexible and printable electronics. The covered topics are broadly organized by the device technologies (sections 1–9), fabrication techniques (s…
View article: Conduction Cooling and Plasmonic Heating Dramatically Increase Droplet Vitrification Volumes for Cell Cryopreservation
Conduction Cooling and Plasmonic Heating Dramatically Increase Droplet Vitrification Volumes for Cell Cryopreservation Open
Droplet vitrification has emerged as a promising ice‐free cryopreservation approach to provide a supply chain for off‐the‐shelf cell products in cell therapy and regenerative medicine applications. Translation of this approach requires the…
View article: 3D printed self-supporting elastomeric structures for multifunctional microfluidics
3D printed self-supporting elastomeric structures for multifunctional microfluidics Open
3D printed self-supporting microfluidics can be directly integrated with sensors and implemented on curvilinear surfaces.
View article: 3D printed patient-specific aortic root models with internal sensors for minimally invasive applications
3D printed patient-specific aortic root models with internal sensors for minimally invasive applications Open
3D printed patient-specific aortic root models with internal sensor arrays can augment the planning of medical procedures.
View article: Supporting data for "3D printed electrically-driven soft actuators"
Supporting data for "3D printed electrically-driven soft actuators" Open
The data set includes the experimental data and the corresponding code files for 3D printed electrically-driven soft actuators.
View article: 3D printed deformable sensors
3D printed deformable sensors Open
A 3D printer can print a soft sensor on a deformable surface such as a breathing lung for spatiotemporal mapping of deformation.
View article: In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid
In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid Open
Rationale: One goal of cardiac tissue engineering is the generation of a living, human pump in vitro that could replace animal models and eventually serve as an in vivo therapeutic. Models that replicate the geometrically complex structure…
View article: 3D Printed Neural Regeneration Devices
3D Printed Neural Regeneration Devices Open
Neural regeneration devices interface with the nervous system and can provide flexibility in material choice, implantation without the need for additional surgeries, and the ability to serve as guides augmented with physical, biological (e…
View article: Supporting data for "3D Printed Deformable Sensors"
Supporting data for "3D Printed Deformable Sensors" Open
The data set includes the experimental data and the corresponding code files supporting the results reported in Zhijie Zhu; Hyun Soo Park; Michael C. McAlpine. 3D Printed Deformable Sensors. Sci. Adv., 2020, DOI: 10.1126/sciadv.aba5575. Th…
View article: Supporting data for "3D Printed Self-Supporting Elastomeric Structures for Multifunctional Microfluidics"
Supporting data for "3D Printed Self-Supporting Elastomeric Structures for Multifunctional Microfluidics" Open
Microfluidic devices fabricated via soft lithography have demonstrated compelling applications in areas such as rapid biochemical assays, lab-on-a-chip diagnostics, DNA microarrays and cell analyses. These technologies could be further dev…
View article: Spinal Cord Scaffolds: 3D Printed Stem‐Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds (Adv. Funct. Mater. 39/2018)
Spinal Cord Scaffolds: 3D Printed Stem‐Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds (Adv. Funct. Mater. 39/2018) Open
A living platform to model complex spinal cord architecture was developed by Ann M. Parr, Michael C. McAlpine, and co-workers and appears in article number 1801850. The approach involves the 3D bioprinting of multicellular neural network s…
View article: 3D Printed Polymer Photodetectors
3D Printed Polymer Photodetectors Open
Extrusion‐based 3D printing, an emerging technology, has been previously used in the comprehensive fabrication of light‐emitting diodes using various functional inks, without cleanrooms or conventional microfabrication techniques. Here, po…
View article: 3D Printed Stem‐Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds
3D Printed Stem‐Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds Open
A bioengineered spinal cord is fabricated via extrusion‐based multimaterial 3D bioprinting, in which clusters of induced pluripotent stem cell (iPSC)‐derived spinal neuronal progenitor cells (sNPCs) and oligodendrocyte progenitor cells (OP…
View article: 3D Printing: 3D Printed Functional and Biological Materials on Moving Freeform Surfaces (Adv. Mater. 23/2018)
3D Printing: 3D Printed Functional and Biological Materials on Moving Freeform Surfaces (Adv. Mater. 23/2018) Open
A closed-loop "adaptive" 3D-printing system and ambient-processable conductive inks are developed by Michael C. McAlpine and co-workers in article number 1707495 for the direct 3D printing of functional materials and devices onto arbitrari…
View article: 3D Printed Functional and Biological Materials on Moving Freeform Surfaces
3D Printed Functional and Biological Materials on Moving Freeform Surfaces Open
Conventional 3D printing technologies typically rely on open‐loop, calibrate‐then‐print operation procedures. An alternative approach is adaptive 3D printing, which is a closed‐loop method that combines real‐time feedback control and direc…
View article: 3D Printed Organ Models for Surgical Applications
3D Printed Organ Models for Surgical Applications Open
Medical errors are a major concern in clinical practice, suggesting the need for advanced surgical aids for preoperative planning and rehearsal. Conventionally, CT and MRI scans, as well as 3D visualization techniques, have been utilized a…
View article: Bioprinting: 3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors (Adv. Mater. Technol. 3/2018)
Bioprinting: 3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors (Adv. Mater. Technol. 3/2018) Open
In article number 1700235, Robert M. Sweet, Michael C. McAlpine, and co-workers designed and developed 3D printed organ models with physical properties of tissue and integrated sensors for surgical planning and rehearsal. The cover image i…
View article: Supporting data for "3D printed patient-specific aortic root models with internal sensors for minimally invasive applications"
Supporting data for "3D printed patient-specific aortic root models with internal sensors for minimally invasive applications" Open
Minimally invasive surgeries have numerous advantages, yet complications may arise from limited knowledge about the anatomical site targeted for the delivery of therapy. Transcatheter aortic valve replacement (TAVR) is a minimally invasive…