Michael Parry
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View article: Improving oncological outcomes for pelvic bone sarcomas: Is it possible?
Improving oncological outcomes for pelvic bone sarcomas: Is it possible? Open
Advances in centralization, and technical advances have significantly improved local control and survival, particularly for chondrosarcoma and sacral chordoma. However, outcomes for osteosarcoma and ES remain constrained, highlighting the …
View article: UK guidelines for the management of bone sarcomas
UK guidelines for the management of bone sarcomas Open
This document is an update of the British Sarcoma Group guidelines (2016) and provides a reference standard for the clinical care of UK patients with primary malignant bone tumours (PMBT) and giant cell tumours (GCTB) of bone. The guidelin…
View article: A Prospective Observational Cohort Study for Newly Diagnosed Osteosarcoma Patients in the UK: ICONIC Study Initial Results
A Prospective Observational Cohort Study for Newly Diagnosed Osteosarcoma Patients in the UK: ICONIC Study Initial Results Open
There has been little change to the standard treatment for osteosarcoma (OS) over the last 25 years and there is an unmet need to identify new biomarkers and novel therapeutic approaches if outcomes are to improve. Furthermore, there is li…
View article: Can the Cartilaginous Thickness Determine the Risk of Malignancy in Pelvic Cartilaginous Tumors, and How Accurate is the Preoperative Biopsy of These Tumors?
Can the Cartilaginous Thickness Determine the Risk of Malignancy in Pelvic Cartilaginous Tumors, and How Accurate is the Preoperative Biopsy of These Tumors? Open
Background Peripheral osteochondral tumors are common, and the management of tumors presenting in the pelvis is challenging and a controversial topic. Some have suggested that cartilage cap thickness may indicate malignant potential, but t…
View article: Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component?
Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component? Open
Background: Chondrosarcoma (CS) is the second most common surgically treated primary malignancy of the bone. The current study explored the effect of the margin and extraosseous tumor component in CS in the femur on local recurrence (LR), …
View article: Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations Open
The results of this study has shown that the metastatic potential of intraosseous conventional central chondrosarcoma is negligible. The presence of an extraosseous soft tissue component may be used for prognostication and to guide treatme…
View article: Outcomes of two-stage revision of endoprostheses of the lower-limb in oncology surgery: Limb-salvage
Outcomes of two-stage revision of endoprostheses of the lower-limb in oncology surgery: Limb-salvage Open
Background: Two-stage revision remains the gold standard to eradicate deep infection of endoprosthetic replacements following bone tumour removal. We aim to (1) report the infection eradication and limb-salvage rate with two-stage revision…
View article: Pelvic bone sarcomas, prognostic factors, and treatment: A narrative review of the literature
Pelvic bone sarcomas, prognostic factors, and treatment: A narrative review of the literature Open
Primary sarcomas of bone are rare malignant mesenchymal tumors. The most common bone sarcomas are osteosarcoma, Ewing’s sarcoma, and chondrosarcoma. The prognosis has improved over the years, but bone sarcomas are still life-threatening tu…
View article: Chondrosarcoma of the Proximal Humerus: Does the Margin Affect Survival?
Chondrosarcoma of the Proximal Humerus: Does the Margin Affect Survival? Open
Chondrosarcoma (CS) is the second most common primary malignant bone tumour and, in the absence of reliable chemotherapy and radiotherapy, is effectively a surgical disease. Overall disease specific survival (DSS) is affected by tumour gra…
View article: 595 Outcomes of Two-Stage Revision Surgery of Oncology Endoprostheses for Prosthetic Joint Infection
595 Outcomes of Two-Stage Revision Surgery of Oncology Endoprostheses for Prosthetic Joint Infection Open
Aim We aim to report the outcomes of two-stage revision surgery to eradicate periprosthetic joint infection (PJI) of endoprostheses in orthopaedic oncology. Method A retrospective review of 44 patients who underwent two-stage revision surg…
View article: 631 A Comparison of the Microbiology Profile for Two-Stage Revision Surgery in Periprosthetic Joint Infection (PJI) of Primary Knee Arthroplasty and Lower Limb Endoprostheses for Tumour Surgery
631 A Comparison of the Microbiology Profile for Two-Stage Revision Surgery in Periprosthetic Joint Infection (PJI) of Primary Knee Arthroplasty and Lower Limb Endoprostheses for Tumour Surgery Open
Aim To compare the microbiology organisms responsible for PJI in patients who underwent two-stage revision of infected primary knee replacement with two-stage revision of infected oncological endoprostheses of the lower limb in a single in…
View article: 873 Outcomes of the Gastrocnemius Flap Performed by Orthopaedic Surgeons in Salvage Revision Knee Arthroplasty
873 Outcomes of the Gastrocnemius Flap Performed by Orthopaedic Surgeons in Salvage Revision Knee Arthroplasty Open
Aim The primary aim of this study was to evaluate the outcomes of gastrocnemius flaps performed by appropriately trained orthopaedic surgeons for soft-tissue coverage in the context of periprosthetic joint infection (PJI) and, secondly, to…
View article: A comparison of the microbiology profile for periprosthetic joint infection of knee arthroplasty and lower-limb endoprostheses in tumour surgery
A comparison of the microbiology profile for periprosthetic joint infection of knee arthroplasty and lower-limb endoprostheses in tumour surgery Open
Aims: this study compared the patient and microbiological profile of prosthetic joint infection (PJI) for patients treated with two-stage revision for knee arthroplasty with that of lower-limb endoprostheses for oncological resection. Pati…
View article: Outcomes of the gastrocnemius flap performed by orthopaedic surgeons in salvage revision knee arthroplasty
Outcomes of the gastrocnemius flap performed by orthopaedic surgeons in salvage revision knee arthroplasty Open
Introduction: The gastrocnemius myofascial flap is used to manage soft-tissue defects over the anterior aspect of the knee in the context of a patient presenting with a sinus and periprosthetic joint infection (PJI) or extensor mechanism f…
View article: RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma
RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma Open
Purpose The development of biomarkers and molecularly targeted therapies for patients with Ewing sarcoma (ES) in order to minimise morbidity and improve outcome is urgently needed. Here, we set out to isolate and characterise patient-deriv…
View article: Surgical treatment of skeletal metastases in proximal tibia: a multicenter case series of 74 patients
Surgical treatment of skeletal metastases in proximal tibia: a multicenter case series of 74 patients Open
Background and purpose - The proximal tibia is a rare site for metastatic bone disease and is a challenging anatomical site to manage due to the proximity to the knee joint and poor soft tissue envelope. We investigated implant survival an…
View article: The importance of surgical margins in malignant Triton tumour of the trunk and extremities
The importance of surgical margins in malignant Triton tumour of the trunk and extremities Open
Malignant Triton tumour (MTT) is a rare variant of malignant peripheral nerve sheath tumour with partial rhabdomyosarcomatous differentiation. To the best of our knowledge, the importance of the surgical resection margins on the outcome of…
View article: Mortality of high‐risk orthopaedic oncology patients during the COVID‐19 pandemic: A prospective cohort study
Mortality of high‐risk orthopaedic oncology patients during the COVID‐19 pandemic: A prospective cohort study Open
Background and Objectives Should the threshold for orthopaedic oncology surgery during the coronavirus disease‐2019 (COVID‐19) pandemic be higher, particularly in men aged 70 years and older? This study reports the incidence of severe acut…
View article: Is Microscopic Vascular Invasion in Tumor Specimens Associated with Worse Prognosis in Patients with High-grade Localized Osteosarcoma?
Is Microscopic Vascular Invasion in Tumor Specimens Associated with Worse Prognosis in Patients with High-grade Localized Osteosarcoma? Open
Background Other than metastases at diagnosis and histological response to preoperative chemotherapy, there are few reliable predictors of survival in patients with osteosarcoma. Microscopic vascular invasion (MVI) has been identified in t…
View article: Female gender in the hormonally active age group plays a major role in high-grade chondrosarcoma survival
Female gender in the hormonally active age group plays a major role in high-grade chondrosarcoma survival Open
Chondrosarcoma (CS) is a rare malignant neoplasm with cartilage differentiation and is the second most common primary bone malignancy [1,2]. The clinical behaviour and prognosis of these tumours de...
View article: Pelvic reconstruction using pedestal endoprosthesis—experience from Europe
Pelvic reconstruction using pedestal endoprosthesis—experience from Europe Open
Background: Reconstructive techniques following acetabular reconstruction for pelvic primary and metastatic malignancy are technically difficult and are known to have high complication rates. Previous studies of outcomes following pedestal…