Michael C. Salling
YOU?
Author Swipe
View article: Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice
Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice Open
Extracellular-signal regulated protein kinase (ERK1/2) is activated by ethanol in reward-related brain regions. Accordingly, systemic inhibition of ERK1/2 potentiates ethanol reinforcement. However, the brain region(s) that mediate this ef…
View article: Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: Blockade by the mGluR5 antagonist MPEP
Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: Blockade by the mGluR5 antagonist MPEP Open
Relapse to alcohol use after periods of abstinence is a hallmark behavioral pathology of alcoholism and a major clinical problem. Emerging evidence indicates that metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate relapse to …
View article: Constitutive Genetic Deletion of Hcn1 Increases Alcohol Preference during Adolescence
Constitutive Genetic Deletion of Hcn1 Increases Alcohol Preference during Adolescence Open
The hyperpolarization-activated cyclic nucleotide-gated channel (HCN), which underlies the hyperpolarization-activated cation current (Ih), has diverse roles in regulating neuronal excitability across cell types and brain regions. Recently…
View article: Photoactivatable Cre recombinase 3.0 for in vivo mouse applications
Photoactivatable Cre recombinase 3.0 for in vivo mouse applications Open
Optogenetic genome engineering tools enable spatiotemporal control of gene expression and provide new insight into biological function. Here, we report the new version of genetically encoded photoactivatable (PA) Cre recombinase, PA-Cre 3.…
View article: Moderate Alcohol Drinking and the Amygdala Proteome: Identification and Validation of Calcium/Calmodulin Dependent Kinase II and AMPA Receptor Activity as Novel Molecular Mechanisms of the Positive Reinforcing Effects of Alcohol
Moderate Alcohol Drinking and the Amygdala Proteome: Identification and Validation of Calcium/Calmodulin Dependent Kinase II and AMPA Receptor Activity as Novel Molecular Mechanisms of the Positive Reinforcing Effects of Alcohol Open
Despite worldwide consumption of moderate amounts of alcohol, the neural mechanisms that mediate the transition from use to abuse are not fully understood.
View article: Cue-induced reinstatement of alcohol-seeking behavior is associated with increased CaMKII T286 phosphorylation in the reward pathway of mice
Cue-induced reinstatement of alcohol-seeking behavior is associated with increased CaMKII T286 phosphorylation in the reward pathway of mice Open
Cue-induced reinstatement of alcohol-seeking is a hallmark behavioral pathology of addiction. Evidence suggests that reinstatement (e.g., relapse), may be regulated by cell signaling systems that underlie neuroplasticity. A variety of plas…
View article: A Role for CaMKII and ERK1/2 Pathways in Alcohol Self-Administration and Relapse-like Behavior
A Role for CaMKII and ERK1/2 Pathways in Alcohol Self-Administration and Relapse-like Behavior Open
Alcoholism is a debilitating neuropsychiatric disorder that adversely affects many people worldwide. Understanding the neurobiological mechanisms that cause alcohol addiction is paramount to its treatment. New evidence suggests that addict…
View article: Alcohol Consumption during Adolescence in a Mouse Model of Binge Drinking Alters the Intrinsic Excitability and Function of the Prefrontal Cortex through a Reduction in the Hyperpolarization-Activated Cation Current
Alcohol Consumption during Adolescence in a Mouse Model of Binge Drinking Alters the Intrinsic Excitability and Function of the Prefrontal Cortex through a Reduction in the Hyperpolarization-Activated Cation Current Open
Periodic episodes of excessive alcohol consumption ("binge drinking") occur frequently among adolescents, and early binge drinking is associated with an increased risk of alcohol use disorders later in life. The PFC undergoes significant d…
View article: Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain
Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain Open
Significance Neuronal inhibition in the CNS occurs via two mechanisms. Synaptic inhibition is transient and localized; extrasynaptic inhibition is continuous and diffuse. Glycine receptor (GlyR)-mediated synaptic inhibition in spinal cord …
View article: Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways
Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways Open
Rodent models implicate metabotropic glutamate receptors (mGluRs) and downstream signaling pathways in addictive behaviors through metaplasticity. One way mGluRs can influence synaptic plasticity is by regulating the local translation of A…