Christopher M. Reid
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View article: Functional consequence of pathogenic GABRA3 variants determines whether X-linked inheritance is dominant or recessive
Functional consequence of pathogenic GABRA3 variants determines whether X-linked inheritance is dominant or recessive Open
Disorders of GABRA3, the only epilepsy-associated GABA-A receptor subunit gene on the X chromosome, have eluded clinical clarity due to ambiguous inheritance patterns and variable phenotypes. The long-standing assumption that all pathogeni…
View article: Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis
Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis Open
Background and Aims Blood pressure (BP) lowering reduces cardiovascular disease (CVD) risk; however, the benefits of treating patients with normal systolic BP but elevated diastolic BP remain uncertain. Methods Data from 51 randomized cont…
View article: Late-life, visit-to-visit blood pressure variability and its association with sex-specific long-term cognitive outcomes
Late-life, visit-to-visit blood pressure variability and its association with sex-specific long-term cognitive outcomes Open
In 19 114 community-dwelling older adults enrolled in the ASPREE trial, high late-life visit-to-visit blood pressure variability (BPV) was associated with increased risks of incident dementia and cognitive decline during the median 4.7 yea…
View article: Risk factors for suboptimal visual outcomes after cataract surgery: A retrospective study in Guyana
Risk factors for suboptimal visual outcomes after cataract surgery: A retrospective study in Guyana Open
This study aims to assess visual outcomes following cataract surgery and identify key risk factors contributing to suboptimal postoperative vision in Guyana. This retrospective study included 103 patients who underwent cataract surgery bet…
View article: Long-Term Survival Advantage of Total Arterial Revascularization in Elderly Patients Following Coronary Artery Bypass Grafting
Long-Term Survival Advantage of Total Arterial Revascularization in Elderly Patients Following Coronary Artery Bypass Grafting Open
TAR improves long-term survival in both elderly and younger patients. These findings challenge the assumption that limited life expectancy precludes arterial grafting and support broader implementation of TAR in appropriately selected olde…
View article: Long‐Term Blood Pressure Variability and Physical Performance in Older Adults
Long‐Term Blood Pressure Variability and Physical Performance in Older Adults Open
High variability in long‐term blood pressure (BPV) independently predicts cardiovascular disease and cognitive decline. Increased BPV and declining physical performance may share mechanistic pathways. However, associations of BPV with gait…
View article: Radial Versus Femoral Access for Percutaneous Coronary Intervention in Patients With Chronic Coronary Disease
Radial Versus Femoral Access for Percutaneous Coronary Intervention in Patients With Chronic Coronary Disease Open
Guidelines recommend trans-radial access (TRA) for all percutaneous coronary intervention (PCI). However, no randomized trials have shown a lower mortality when compared to the femoral approach in chronic coronary disease and femoral acces…
View article: Withdrawal of heart failure therapy after atrial fibrillation rhythm control with ejection fraction normalization: the WITHDRAW-AF trial
Withdrawal of heart failure therapy after atrial fibrillation rhythm control with ejection fraction normalization: the WITHDRAW-AF trial Open
Background and Aims Atrial fibrillation-mediated cardiomyopathy (AFCM) represents an important reversible cause of left ventricular systolic dysfunction. Current clinical practice is indefinite heart failure (HF) pharmacotherapy despite le…
View article: Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals
Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals Open
Astrocyte specification during development is influenced by both intrinsic and extrinsic factors, but the precise contribution of each remains poorly understood. Here we show that mouse septal astrocytes derived from Nkx2.1 - and Zic4 -exp…
View article: Medication persistence trajectories among individuals prescribed lipid‐lowering therapy in primary care settings: A retrospective cohort study
Medication persistence trajectories among individuals prescribed lipid‐lowering therapy in primary care settings: A retrospective cohort study Open
Aims This study aimed to identify distinct trajectories of lipid‐modifying medication (LMM) persistence over time and to explore characteristics associated with each pattern. Methods Using primary care data from IQVIA, we conducted a retro…
View article: A Prospective, Multicentre Randomised Controlled Study of Angiographic and Clinical Outcomes in Total Arterial Coronary Bypass Grafting: The TA Trial Protocol
A Prospective, Multicentre Randomised Controlled Study of Angiographic and Clinical Outcomes in Total Arterial Coronary Bypass Grafting: The TA Trial Protocol Open
The trial has been registered under the Australian New Zealand Clinical Trial Registry (registration number: ACTRN12623000864628). Dissemination of results: The analysed results will be published in a peer-reviewed journal on completion of…
View article: Economic evaluation of type 2 diabetes mellitus T2DM pharmaceutical treatment compared to an alternative, conducted alongside randomized controlled trials: A scoping review
Economic evaluation of type 2 diabetes mellitus T2DM pharmaceutical treatment compared to an alternative, conducted alongside randomized controlled trials: A scoping review Open
Objective Diabetes mellitus is recognized as one of the most challenging health conditions facing all healthcare systems around the world and poses a high burden on individuals and society. Prevention of type 2 diabetes via screening progr…
View article: Evaluating methods to detect variation in hospital level mortality and renal insufficiency within an Australian cardiac surgery registry
Evaluating methods to detect variation in hospital level mortality and renal insufficiency within an Australian cardiac surgery registry Open
Clinical registries should consider their data parameters before commencing benchmarking to detect underperforming sites. To optimise accuracy of outlier flagging, outcomes should be risk-adjusted, cumulative datasets should be used in the…
View article: Systematic review and meta-analysis of respiratory viral triggers for acute myocardial infarction and stroke
Systematic review and meta-analysis of respiratory viral triggers for acute myocardial infarction and stroke Open
Respiratory viral infections may trigger acute cardiovascular events. However, relative pathogen-specific associations are poorly understood, limiting optimal preventive recommendations. The aim of this study was to systematically review t…
View article: Effectiveness of data-driven quality improvement on hospitalizations and health outcomes for people with coronary heart disease in primary care (QUEL): a cluster randomised controlled trial with 24-month follow-up
Effectiveness of data-driven quality improvement on hospitalizations and health outcomes for people with coronary heart disease in primary care (QUEL): a cluster randomised controlled trial with 24-month follow-up Open
Background Using data to drive improved health outcomes offers an healthcare approach that has potential to benefit secondary prevention of coronary heart disease (CHD). The aim of this trial was to test the effectiveness of a data-driven …
View article: STAREE-HEART: A randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants
STAREE-HEART: A randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants Open
clinicaltrials.gov. Unique identifier: NCT04536870.
View article: Discontinuation of lipid-modifying agents and failure to achieve target LDL cholesterol levels across cardiovascular risk groups
Discontinuation of lipid-modifying agents and failure to achieve target LDL cholesterol levels across cardiovascular risk groups Open
Long-term adherence to LMAs remains a challenge, particularly in low-risk. Target achievement was poor, highlighting gaps in therapeutic optimization, patient engagement, and monitoring.
View article: Estimation of the Duration of Antihypertensive Prescriptions: Validation of a Data‐Driven Approach Using Rotterdam Study Data
Estimation of the Duration of Antihypertensive Prescriptions: Validation of a Data‐Driven Approach Using Rotterdam Study Data Open
Objectives Administrative medicine dispensing data often omit prescribed duration, which is important for research on adherence or other pharmacoepidemiological topics. While the reverse waiting time distribution (rWTD) method has been wid…
View article: National Survey of Rapid Access Chest Pain Clinics in Australia
National Survey of Rapid Access Chest Pain Clinics in Australia Open
Our survey is the first known to describe the national implementation of RACC and map the delivery of care in Australia. An additional outcome is the development of a national network of centres to collaboratively develop a "best practice"…
View article: Survival Outcomes After Multiple vs Single Arterial Grafting Among Patients With Reduced Ejection Fraction
Survival Outcomes After Multiple vs Single Arterial Grafting Among Patients With Reduced Ejection Fraction Open
Importance Multiarterial coronary bypass procedures offer improved clinical outcomes compared with single arterial grafting with supplementary saphenous vein grafts. However, the survival advantage of multiarterial grafting across varying …
View article: Dual Antiplatelet Therapy Prior to Percutaneous Coronary Intervention for Acute Coronary Syndrome: Prevalence and Outcomes in Contemporary Practice
Dual Antiplatelet Therapy Prior to Percutaneous Coronary Intervention for Acute Coronary Syndrome: Prevalence and Outcomes in Contemporary Practice Open
Background Dual antiplatelet therapy (DAPT) is standard following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). Preloading is the practice of administering both aspirin and a P2Y 12 inhibitor before PCI. DAPT …
View article: Effect of a Telemedicine Model on Patients With Heart Failure With Reduced Ejection Fraction in a Resource-Limited Setting in Vietnam: Cohort Study
Effect of a Telemedicine Model on Patients With Heart Failure With Reduced Ejection Fraction in a Resource-Limited Setting in Vietnam: Cohort Study Open
Background Heart failure (HF) is a complex, life-threatening condition marked by high morbidity, mortality, reduced functional capacity, poor quality of life, and substantial health care costs. HF with reduced ejection fraction (HFrEF) rep…
View article: Dyslipidemia and cerebral atrophy among health check-up individuals: A cross-sectional study
Dyslipidemia and cerebral atrophy among health check-up individuals: A cross-sectional study Open
This cross-sectional study conducted in China is the first to identify that health check-up examinees with cerebral atrophy had lower levels of TC and LDL-C raising the possible association between lower levels of TC and LDL-C with cerebra…
View article: Risk Prediction Modelling of 30-day all-cause mortality following percutaneous coronary intervention in an Australian population: Leveraging Machine Learning
Risk Prediction Modelling of 30-day all-cause mortality following percutaneous coronary intervention in an Australian population: Leveraging Machine Learning Open
Background Pre-procedural risk prediction of 30-day all-cause mortality after percutaneous coronary intervention (PCI) aids in clinical decision-making and benchmarking hospital performance. This study aimed to identify pre-procedural fact…