Explanipedia

Adverse outcomes in patients with atrial fibrillation and a pacemaker: a cohort study Open

Veronika Meier, Stefanie Aeschbacher, Michael Coslovsky, Andreas Gasser, Rebecca E. Paladini , et al. · 2025

Aims Patients with atrial fibrillation (AF) are at a high risk of adverse cardiovascular outcomes. Little is known about the specific population of AF patients with implanted pacemaker (PM) and their prognosis. Therefore, we aimed to compa…

External Validation of the REACT‐HF Score for Predicting Heart Failure in Patients With Atrial Fibrillation Open

Giorgio Moschovitis, Elia Rigamonti, Andrea Wiencierz, Michael Coslovsky, Steffen Blum , et al. · 2025

Background Validated risk prediction scores for incident heart failure (HF) in patients with atrial fibrillation are lacking. We aimed to externally validate the the HF prediction risk score derived from three large control randomized tria…

Cost‐Effectiveness of Drug‐Coated Balloons in the Treatment of Coronary Small Vessel Disease: A Report From the BASKET‐SMALL 2 Randomized Controlled Trial Open

Marco Cattaneo, Michael Coslovsky, Samuel J. P. Malkin, Gregor Fahrni, Christoph Kaiser , et al. · 2025

Background Drug‐coated balloons (DCB) are noninferior to second‐generation drug‐eluting stents (DES) in the treatment of small vessel coronary artery disease regarding major adverse cardiac events (MACE). However, the economic implication …

Discrimination of atrial fibrillation burden using clinical and cardiac imaging data Open

Andreas Gasser, Michael Coslovsky, M Liskij, Tobias Reichlin, L Roten , et al. · 2025

Background Current literature suggests that atrial fibrillation (AF) burden has prognostic implications in AF patients. However, it is not feasible to assess AF burden in all AF patients. Therefore, we aim to investigate whether clinical a…

Adverse outcomes in patients with atrial fibrillation and a pacemaker: a cohort study Open

Valeria Meier, Michael Coslovsky, R. Kerler, Tobias Reichlin, Nicolas Rodondi , et al. · 2025

Background Patients with atrial fibrillation (AF) have a higher rate of pacemaker (PM) implantations compared to the general population. Little is known if a present PM in AF patients is associated with adverse cardiovascular outcomes. We …

Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation Open

Vasco Iten, Elena Herber, Michael Coslovsky, Elisa Hennings, Rebecca E. Paladini , et al. · 2024

ClinicalTrials.gov Identifier: NCT02105844.

Cigarette Smoking and Structural Brain Deficits in Patients With Atrial Fibrillation Open

Raffaele Peter, Stefanie Aeschbacher, Rebecca E. Paladini, Michael Coslovsky, Philipp Krisai , et al. · 2024

Cigarette smoking and atrial fibrillation (AF) are associated with impaired brain health. We investigated the association between smoking habits and brain lesions and volume in patients with AF. In patients with AF from a multicenter cohor…

BMP10 reflects pre-capillary pulmonary hemodynamics: association of biomarkers and hemodynamic parameters in pulmonary hypertension Open

Elisa Hennings, Stefanie Aeschbacher, Michael Coslovsky, Rebecca E. Paladini, Gian Voellmin , et al. · 2024

Blood pressure, brain lesions and cognitive decline in patients with atrial fibrillation Open

Desirée Carmine, Stefanie Aeschbacher, Michael Coslovsky, Elisa Hennings, Rebecca E. Paladini , et al. · 2024

Background The influence of atrial fibrillation (AF) and blood pressure (BP) on brain lesions and cognitive function is unclear. We aimed to investigate the association of BP with different types of brain lesions and cognitive decline in p…

Heart rate variability and stroke or systemic embolism in patients with atrial fibrillation Open

Peter Hämmerle, Stefanie Aeschbacher, Vincent Schlageter, Michael Coslovsky, Elisa Hennings , et al. · 2024

HRVI measured during SR on a single 5-minute ECG recording is independently associated with stroke or systemic embolism in AF patients. HRV analysis in SR may help to improve risk stratification in AF patients.

Association of sex with heart rate variability in atrial fibrillation patients Open

Peter Hämmerle, Johannes Schier, Vincent Schlageter, Sven Knecht, Stefanie Aeschbacher , et al. · 2024

Background Sex-specific differences in cardiac autonomic tone have not been thoroughly investigated in patients with atrial fibrillation (AF) but may play a relevant role. Purpose We aimed to investigate cardiac autonomic function of femal…

Association of brain infarcts and cardiac autonomic dysfunction using entropy functions in patients with atrial fibrillation Open

Christine Meyer‐Zürn, Johannes Schier, Vincent Schlageter, Sven Knecht, Stefanie Aeschbacher , et al. · 2024

Background Cardiac autonomic dysfunction after brain infarcts is a strong predictor of adverse outcome. Purpose The aim of this study was to investigate the association of large cortical or non-cortical brain infarcts (LNCCI) with multisca…

Patients on vitamin K treatment: is switching to direct-acting oral anticoagulation cost-effective? A target trial on a prospective cohort Open

Helena Aebersold, Fabienne Foster‐Witassek, Stefanie Aeschbacher, Jürg H. Beer, Eva Blozik , et al. · 2024

Aims Direct-acting oral anticoagulants (DOACs) have, to a substantial degree, replaced vitamin K antagonists (VKA) as treatments for stroke prevention in atrial fibrillation (AF) patients. However, evidence on the real-world causal effects…

Longitudinal Changes in Health‐Related Quality of Life in Patients With Atrial Fibrillation Open

Fabienne Foster‐Witassek, Helena Aebersold, Stefanie Aeschbacher, Peter Ammann, Jürg H. Beer , et al. · 2023

Background Optimizing health‐related quality of life (HRQoL) is an important aim of atrial fibrillation (AF) treatment. Little is known about patients' long‐term HRQoL trajectories and the impact of patient and disease characteristics. The…

Cigarette smoking and structural brain deficits in patients with atrial fibrillation Open

R. Peter, Stefanie Aeschbacher, Michael Coslovsky, Philipp Krisai, Nicolas Rodondi , et al. · 2023

Background Brain lesions are common in patients with atrial fibrillation (AF). Whether cigarette smoking is associated with an increased risk of brain lesions and reduced brain volume in patients with AF is currently unknown. Purpose In th…

Kidney function by creatinine and cystatin c and adverse cardiovascular outcomes in patients with atrial fibrillation Open

Adrian Schweigler, Elisa Hennings, Stefanie Aeschbacher, Nicolas Rodondi, A Stauber , et al. · 2023

Background Atrial fibrillation (AF) patients with chronic kidney disease are at an increased risk for ischemic and bleeding events and all-cause mortality. Accurate kidney function estimation is key for risk assessment. Creatinine is commo…

Biomarkers for the prediction of cognitive decline in atrial fibrillation patients Open

Philipp Krisai, Matthias Eberl, Michael Coslovsky, Nicolas Rodondi, Patricia Chocano-Bedoya , et al. · 2023

Background Patients with atrial fibrillation (AF) are at increased risk of cognitive decline. Biomarkers might help to identify the highest risk patients. Purpose To investigate associations of a broad panel of biomarkers with cognitive de…

Association between blood pressure and new brain white matter lesions in atrial fibrillation patients Open

DDe Angelis Carmine, Stefanie Aeschbacher, Michael Coslovsky, Elisa Hennings, Philipp Krisai , et al. · 2023

Background Atrial fibrillation (AF) and hypertension (HTN) often occur together. A cross-sectional study in patients with AF has shown that blood pressure (BP) is associated with white matter lesions (WML), which are known to have a negati…

Coffee consumption and adverse outcome events in patients with atrial fibrillation Open

Vasco Iten, Michael Coslovsky, Elisa Hennings, Tobias Reichlin, Nicolas Rodondi , et al. · 2023

Background/Introduction Moderate coffee consumption has been associated with a lower risk of major adverse cardiovascular events (MACE) in the general population. However, there are some concerns that coffee consumption might be harmful fo…

External validation of the new REACT-HF score for heart failure prediction in patients with atrial fibrillation Open

Giorgio Moschovitis, Elia Rigamonti, Andrea Wiencierz, Michael Coslovsky, Steffen Blum , et al. · 2023

Background Heart failure (HF) represents the main cause of hospital admissions and deaths among atrial fibrillation (AF) patients, but precise risk prediction tools are lacking. Recently, the REACT-HF score has been developed to predict in…

Real-World Cost-Effectiveness of Pulmonary Vein Isolation for Atrial Fibrillation: A Target Trial Approach Open

Miquel Serra‐Burriel, Helena Aebersold, Fabienne Foster‐Witassek, Michael Coslovsky, Nicolas Rodondi , et al. · 2023

Mid-term changes in cognitive functions in patients with atrial fibrillation: a longitudinal analysis of the Swiss-AF cohort Open

Alexandra S. Wueest, Priska Zuber, Michael Coslovsky, Nikki Rommers, Nicolas Rodondi , et al. · 2023

Background Longitudinal association studies of atrial fibrillation (AF) and cognitive functions have shown an unclear role of AF-type and often differ in methodological aspects. We therefore aim to investigate longitudinal changes in cogni…

Omega‐3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation Open

Philipp Baumgartner, Martin F. Reiner, Andrea Wiencierz, Michael Coslovsky, Nicole R. Bonetti , et al. · 2023

Background Previous randomized control trials showed mixed results concerning the effect of omega‐3 fatty acids (n‐3 FAs) on atrial fibrillation (AF). The associations of n‐3 FA blood levels with heart rhythm in patients with established A…

Association of bone morphogenetic protein 10 and recurrent atrial fibrillation after catheter ablation Open

Elisa Hennings, Stefanie Aeschbacher, Michael Coslovsky, Rebecca E. Paladini, Pascal Meyre , et al. · 2023

Aims Atrial remodelling, defined as a change in atrial structure, promotes atrial fibrillation (AF). Bone morphogenetic protein 10 (BMP10) is an atrial-specific biomarker released to blood during atrial development and structural changes. …

Association of statin use and lipid levels with cerebral microbleeds and intracranial hemorrhage in patients with atrial fibrillation: A prospective cohort study Open

Elisavet Moutzouri, Matthias Glutz, Nazanin Abolhassani, Martin Feller, Luise Adam , et al. · 2023

Background: An increased risk of intracranial hemorrhage (ICH) associated with statins has been reported, but data on the relationship between statin use and cerebral microbleeds (CMBs) in patients with atrial fibrillation (AF), a populati…

Bone morphogenetic protein 10 as a predictor for recurrent atrial fibrillation after catheter ablation Open

Elisa Hennings, Stefanie Aeschbacher, Michael Coslovsky, Rebecca E. Paladini, Florian Spies , et al. · 2023

Funding Acknowledgements Type of funding sources: None. Background Atrial fibrillation (AF) recurrence after catheter ablation (CA) poses a major challenge. The novel atrial-specific biomarker, bone morphogenetic protein 10 (BMP10), might …

Assessment of the atrial fibrillation burden in Holter ECG recordings using artificial intelligence Open

Elisa Hennings, Michael Coslovsky, Rebecca E. Paladini, Stefanie Aeschbacher, Sven Knecht , et al. · 2023

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Swiss National Science Foundation, Swiss Heart Foundation Background Emerging evidence indicates that a high atrial fibrillation (AF) burden is associate…

Brain lesions and cognitive decline in patients with atrial fibrillation Open

Elisa Hennings, Katalin Bhend, Rebecca E. Paladini, Stefanie Aeschbacher, Michael Coslovsky , et al. · 2023

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Swiss National Science Foundation, Swiss Heart Foundation Background In addition to clinical stroke, atrial fibrillation (AF) is associated with a high b…

Association of cardiac rhythm with cognitive performance in atrial fibrillation patients Open

Laura Mosher, Michael Coslovsky, Elisa Hennings, Stefanie Aeschbacher, Rebecca E. Paladini , et al. · 2023

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Swiss National Science Foundation, Swiss Heart Foundation, Background Atrial fibrillation (AF) is strongly associated with an increased risk of cognitive…

Bone Morphogenetic Protein 10—A Novel Biomarker to Predict Adverse Outcomes in Patients With Atrial Fibrillation Open

Elisa Hennings, Steffen Blum, Stefanie Aeschbacher, Michael Coslovsky, Sven Knecht , et al. · 2023

Background Patients with atrial fibrillation (AF) face an increased risk of death and major adverse cardiovascular events (MACE). We aimed to assess the predictive value of the novel atrial‐specific biomarker BMP10 (bone morphogenetic prot…

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