Michael Costello
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View article: Polycystic ovary syndrome perspectives from patients and health professionals on clinical features, current name, and renaming: a longitudinal international online survey
Polycystic ovary syndrome perspectives from patients and health professionals on clinical features, current name, and renaming: a longitudinal international online survey Open
The Australian National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Women's Health in Reproductive Life (CRE-WHiRL) [APP#1171592].
View article: The Role of Nutrient Supplements in Female Infertility: An Umbrella Review and Hierarchical Evidence Synthesis
The Role of Nutrient Supplements in Female Infertility: An Umbrella Review and Hierarchical Evidence Synthesis Open
Background and Objectives: Nutrient supplements are commonly used to improve fertility outcomes by women with infertility trying to conceive spontaneously or utilising medically assisted reproduction (MAR). However, despite their widesprea…
View article: International PCOS guideline clinical research priorities roadmap: a co-designed approach aligned with end-user priorities in a neglected women’s health condition
International PCOS guideline clinical research priorities roadmap: a co-designed approach aligned with end-user priorities in a neglected women’s health condition Open
The survey, International PCOS Guideline Network and 2018 and 2023 International PCOS Guidelines were funded by the Australian National Health and Medical Research Council (NHMRC) Centres of Research excellence in PCOS (APP1078444) and in …
View article: Recommendations from the 2024 Australian evidence‐based guideline for unexplained infertility: <scp>ADAPTE</scp> process from the <scp>ESHRE</scp> evidence‐based guideline on unexplained infertility
Recommendations from the 2024 Australian evidence‐based guideline for unexplained infertility: <span>ADAPTE</span> process from the <span>ESHRE</span> evidence‐based guideline on unexplained infertility Open
Introduction The 2024 Australian evidence‐based guideline for unexplained infertility provides clinicians with evidence‐based recommendations for the optimal diagnostic workup for infertile couples to establish the diagnosis of unexplained…
View article: Summary of the 2023 international evidence‐based guideline for the assessment and management of polycystic ovary syndrome: an Australian perspective
Summary of the 2023 international evidence‐based guideline for the assessment and management of polycystic ovary syndrome: an Australian perspective Open
Introduction The Australian‐led 2023 International evidence‐based guideline for the assessment and management of polycystic ovary syndrome was based on best available evidence, clinical expertise and consumer preference. It followed best p…
View article: Research Integrity in Guidelines and evIDence synthesis (RIGID): a framework for assessing research integrity in guideline development and evidence synthesis
Research Integrity in Guidelines and evIDence synthesis (RIGID): a framework for assessing research integrity in guideline development and evidence synthesis Open
This study received no specific funding. The guideline in which it was piloted was supported by the Australian National Health and Medical Research Council (NHMRC) for guideline development through the Centre of Research Excellence (CRE) i…
View article: Health needs, treatment decisions and experience of traditional complementary and integrative medicine use by women with diminished ovarian reserve: A cross‐sectional survey
Health needs, treatment decisions and experience of traditional complementary and integrative medicine use by women with diminished ovarian reserve: A cross‐sectional survey Open
Background Women with diminished ovarian reserve (DOR) have fewer eggs than would be expected at their age. It is estimated that 10% of women seeking fertility treatment are diagnosed with DOR. However, the success rate of medically assist…
View article: Establishing key components of naturopathic management of women with diminished ovarian reserve: A Delphi study
Establishing key components of naturopathic management of women with diminished ovarian reserve: A Delphi study Open
• This Delphi study identifies key naturopathic treatment elements for women with diminished ovarian reserve (DOR). • Naturopathic treatment is individualised and targets general well-being and/or fertility in women with DOR. • It is a rob…
View article: Effectiveness of naturopathy for pregnancy in women with diminished ovarian reserve: feasibility randomized controlled trial
Effectiveness of naturopathy for pregnancy in women with diminished ovarian reserve: feasibility randomized controlled trial Open
The evaluation of whole-system naturopathy through a RCT was feasible and the treatment was acceptable and well tolerated according to women with DOR. Outcomes from this study will help inform sample size calculations powered for fertility…
View article: IVF versus IUI with ovarian stimulation for unexplained infertility: a collaborative individual participant data meta-analysis
IVF versus IUI with ovarian stimulation for unexplained infertility: a collaborative individual participant data meta-analysis Open
BACKGROUND IVF and IUI with ovarian stimulation (IUI-OS) are widely used in managing unexplained infertility. IUI-OS is generally considered first-line therapy, followed by IVF only if IUI-OS is unsuccessful after several attempts. However…
View article: Naturopaths’ approach to care of women with infertility: A cross-sectional survey
Naturopaths’ approach to care of women with infertility: A cross-sectional survey Open
Infertility affects approximately one in six couples of reproductive age. Many women use traditional complementary and integrative medicine to improve their chances of conceiving. While there is evidence of the use of naturopathy by women …
View article: Evidence-based guideline: unexplained infertility
Evidence-based guideline: unexplained infertility Open
STUDY QUESTION What is the recommended management for couples presenting with unexplained infertility (UI), based on the best available evidence in the literature? SUMMARY ANSWER The evidence-based guideline on UI makes 52 recommendations …
View article: Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome
Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome Open
STUDY QUESTION What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference? SUMMARY ANSWER International evidence-based…
View article: Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome Open
Study Question What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference? Summary Answer International evidence-based…
View article: Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome
Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome Open
Study question What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference? Summary answer International evidence-based…
View article: Statins for women with polycystic ovary syndrome not actively trying to conceive
Statins for women with polycystic ovary syndrome not actively trying to conceive Open
The evidence for all main outcomes of this review was of very low certainty. Due to the limited evidence, we are uncertain if statins compared with placebo, or statins plus metformin compared with metformin alone, improve resumption of men…
View article: P-169 In vitro fertilization versus intrauterine insemination with ovarian stimulation for unexplained infertility: A Collaborative Meta-analysis with Individual Participant Data
P-169 In vitro fertilization versus intrauterine insemination with ovarian stimulation for unexplained infertility: A Collaborative Meta-analysis with Individual Participant Data Open
Study question In couples with unexplained infertility, does IVF increase cumulative live birth rate and reduce multiple pregnancy rate compared to intrauterine insemination with ovarian stimulation (IUI-OS)? Summary answer There were no s…
View article: O-094 Management of subfertility in women with PCOS: expectations, problems and solutions
O-094 Management of subfertility in women with PCOS: expectations, problems and solutions Open
Polycystic ovarian syndrome (PCOS) is a common cause of subfertility particularly when anovulation is present. In this circumstance efforts are made to induce ovulation through lifestyle modification, medication, or a combination of both. …
View article: O-203 Unexplained infertility: diagnosis by exclusion
O-203 Unexplained infertility: diagnosis by exclusion Open
Study question: What is the optimal work-up to establish the diagnosis of unexplained infertility, based on the best available evidence in the literature? Summary answer: The ESHRE Guideline on Unexplained Infertility provides 35 recommend…
View article: Heating subsurface formations by oxidizing fuel on a fuel carrier
Heating subsurface formations by oxidizing fuel on a fuel carrier Open
A method of heating a portion of a subsurface formation includes drawing fuel on a fuel carrier through an opening formed in the formation. Oxidant is supplied to the fuel at one or more locations in the opening. The fuel is combusted with…
View article: Effect of Smartphone App–Based Education on Clinician Prescribing Habits in a Learning Health Care System
Effect of Smartphone App–Based Education on Clinician Prescribing Habits in a Learning Health Care System Open
ClinicalTrials.gov Identifier: NCT03771482.
View article: Impact of an Asynchronous Spaced Education Learning Intervention on Emergency Medicine Clinician Opioid Prescribing
Impact of an Asynchronous Spaced Education Learning Intervention on Emergency Medicine Clinician Opioid Prescribing Open
Introduction Opioid prescribing has contributed to the opioid crisis and education has focused on improved opioid stewardship. We aimed to evaluate the impact of an asynchronous high-quality education to change emergency medicine (EM) clin…
View article: Computational simulation of pacifier deformation and interaction with the palate
Computational simulation of pacifier deformation and interaction with the palate Open
Objectives The objective of this study is to demonstrate that computational finite element models can be used to reliably simulate dynamic interaction between a pacifier, the palate, and the tongue during nonnutritive sucking (NNS). The in…
View article: “The whole package deal”: experiences of overweight/obese women living with polycystic ovary syndrome
“The whole package deal”: experiences of overweight/obese women living with polycystic ovary syndrome Open
Background Polycystic Ovary Syndrome (PCOS) is a common female reproductive disorder with multiple manifestations. There are relatively few qualitative studies exploring the nature of living with PCOS despite its high prevalence. Qualitati…
View article: Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome
Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome Open
In adult women with PCOS, metformin may be less effective in improving hirsutism compared to the OCP in the subgroup BMI 25 kg/m2 to 30 kg/m2 but we are uncertain if there was a difference between metformin and the OCP in subgroups BMI < 2…
View article: To share or not to share data: how valid are trials evaluating first-line ovulation induction for polycystic ovary syndrome?
To share or not to share data: how valid are trials evaluating first-line ovulation induction for polycystic ovary syndrome? Open
BACKGROUND In our recent individual participant data (IPD) meta-analysis evaluating the effectiveness of first-line ovulation induction for polycystic ovary syndrome (PCOS), IPD were only available from 20 studies of 53 randomized controll…
View article: Health literacy needs in weight management of women with Polycystic Ovary Syndrome
Health literacy needs in weight management of women with Polycystic Ovary Syndrome Open
Issue addressed Lifestyle modification plays a key role in weight management and chronic disease prevention in polycystic ovary syndrome (PCOS). Women with PCOS experience challenges in adopting and maintaining healthy lifestyle behaviours…