Michael Craft
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View article: CCR2 deficiency alters activation of microglia subsets in traumatic brain injury
CCR2 deficiency alters activation of microglia subsets in traumatic brain injury Open
In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid cells have the potential to worsen damage and/or to assist in healing. We define the heterogeneity of microglia and macrophage phenotypes durin…
View article: Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice
Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice Open
CRISPR-Cas systems have emerged as a powerful tool to generate genetic models for studying normal and diseased central nervous system (CNS). Targeted gene disruption at specific loci has been demonstrated successfully in non-dividing neuro…
View article: P4‐058: A NOVEL TRANSGENIC RAT MODEL THAT PRESENTS PATHOPHYSIOLOGICAL LEVELS OF HUMAN TAU IN CSF, AXONOPATHY, HIPPOCAMPAL NETWORK DISRUPTION, AND COGNITIVE DEFICITS
P4‐058: A NOVEL TRANSGENIC RAT MODEL THAT PRESENTS PATHOPHYSIOLOGICAL LEVELS OF HUMAN TAU IN CSF, AXONOPATHY, HIPPOCAMPAL NETWORK DISRUPTION, AND COGNITIVE DEFICITS Open
Current widely used tau transgenic mouse models rely on the supra-physiological expression of a single isoform of human tau harboring a mutation that is not associated with AD. Furthermore, the phenotype of these models is often related to…