Michael Czech
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View article: HSD17B13 Couples Hepatocyte Lipid Metabolism to Stellate Cell Activation via TGFb-1 Signaling
HSD17B13 Couples Hepatocyte Lipid Metabolism to Stellate Cell Activation via TGFb-1 Signaling Open
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease driven by hepatocellular lipid overload, immune activation, and hepatic stellate cell (HSC)-driven fibrogenesis. Human genetic studies reveal that loss-…
View article: Functional Feed Development from Alternanthera philoxeroides for Herbivorous Fish: Effects on Growth Performance, Feed Efficiency, and Hematological Response
Functional Feed Development from Alternanthera philoxeroides for Herbivorous Fish: Effects on Growth Performance, Feed Efficiency, and Hematological Response Open
View article: Thermogenic adipocytes alleviate hepatic steatosis and insulin resistance via macrophage cytokine secretion in obese mice
Thermogenic adipocytes alleviate hepatic steatosis and insulin resistance via macrophage cytokine secretion in obese mice Open
The Nrip1 gene encodes the protein Rip140, which suppresses nuclear receptors that regulate energy metabolism. Here we show adipocyte-selective deficiency of Nrip1 (AdNrip1KO) in mice causes a striking expansion of alternatively activated,…
View article: A dominant CIDEC variant segregates with familial obesity by increasing lipid droplet size in adipocytes
A dominant CIDEC variant segregates with familial obesity by increasing lipid droplet size in adipocytes Open
Adipose tissue dysfunction in obesity is a major global public health risk, contributing to insulin resistance and chronic diseases such as diabetes and cardiovascular disorders. Here, we identify a dominant c.37A>G p.(Arg13Gly) variant in…
View article: Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose <i>de novo</i> lipogenesis
Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose <i>de novo</i> lipogenesis Open
Pancreatic cancer patients have the highest rates and most severe forms of cancer cachexia, yet cachexia etiologies remain largely elusive, leading to a lack of effective intervening therapies. Parathyroid hormone-related protein (PTHrP) h…
View article: NUTRITIONAL AND CAROTENOID CHARACTERIZATION OF YELLOW PUMPKIN (Cucurbita moschata) POWDER FOR POTENTIAL USE IN ORNAMENTAL FISH FEED
NUTRITIONAL AND CAROTENOID CHARACTERIZATION OF YELLOW PUMPKIN (Cucurbita moschata) POWDER FOR POTENTIAL USE IN ORNAMENTAL FISH FEED Open
Yellow pumpkin (Cucurbita moschata) is a natural plant source rich in carotenoids, particularly β-carotene, with promising potential as a functional ingredient in ornamental fish diets. This study aimed to evaluate the nutritional composit…
View article: The autophagy receptor Ncoa4 controls PPARγ activity and thermogenesis in brown adipose tissue
The autophagy receptor Ncoa4 controls PPARγ activity and thermogenesis in brown adipose tissue Open
Adipose tissue dysfunction leads to a variety of deleterious systemic consequences including ectopic lipid deposition and impaired insulin sensitivity. PPARγ is a major regulator of adipocyte differentiation and functionality and is thus a…
View article: Rhodoquinone carries electrons in the mammalian electron transport chain
Rhodoquinone carries electrons in the mammalian electron transport chain Open
Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal electron acceptor oxygen (O2). In hypoxia, ubiquinol (UQH2) diverts t…
View article: Integrative Assessment of Ficus septica as a Functional Phytogenic Additive: Nutritional, Antioxidant, and Immunomodulatory Efficacy in Betta picta Challenged with Aeromonas hydrophila
Integrative Assessment of Ficus septica as a Functional Phytogenic Additive: Nutritional, Antioxidant, and Immunomodulatory Efficacy in Betta picta Challenged with Aeromonas hydrophila Open
The ornamental fish industry is increasingly turning to sustainable, plant-based alternatives to antibiotics for disease prevention and health management. Ficus septica, a tropical medicinal plant rich in bioactive phytochemicals, shows pr…
View article: eLife assessment: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
eLife assessment: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract The energy-burning capability …
View article: Author Response: Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Author Response: Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis Open
View article: eLife Assessment: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
eLife Assessment: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: Author Response: Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Author Response: Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis Open
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice rep…
View article: Reviewer #3 (Public Review): Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Reviewer #3 (Public Review): Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis Open
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice rep…
View article: Reviewer #2 (Public Review): Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Reviewer #2 (Public Review): Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis Open
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice rep…
View article: Reviewer #1 (Public Review): Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Reviewer #1 (Public Review): Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis Open
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice rep…
View article: Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis Open
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice rep…
View article: eLife assessment: Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
eLife assessment: Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Open
View article: eLife assessment: Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
eLife assessment: Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Open
Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly…
View article: eLife assessment: Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity
eLife assessment: Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity Open
View article: Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis Open
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice rep…
View article: Fatty acid availability controls autophagy and associated cell functions
Fatty acid availability controls autophagy and associated cell functions Open
Macroautophagy/autophagy requires enormous membrane expansions during concerted actions of transient autophagic vesicles and lysosomes, yet the source of the membrane lipids is poorly understood. Recent work in adipocytes has now pinpointe…
View article: eLife Assessment: Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity
eLife Assessment: Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity Open
Triglycerides (TG) in adipocytes provide the major stores of metabolic energy in the body. Optimal amounts of TG stores are desirable as insufficient capacity to store TG, as in lipodystrophy, or exceeding the capacity for storage, as in o…
View article: Reviewer #3 (Public Review): Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity
Reviewer #3 (Public Review): Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity Open
Triglycerides (TG) in adipocytes provide the major stores of metabolic energy in the body. Optimal amounts of TG stores are desirable as insufficient capacity to store TG, as in lipodystrophy, or exceeding the capacity for storage, as in o…
View article: Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming
Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming Open
View article: Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice
Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice Open
Nonalcoholic steatohepatitis (NASH) is a malady of multiple cell types associated with hepatocyte triglyceride (TG) accumulation, macrophage inflammation, and stellate cell-induced fibrosis, with no approved therapeutics yet available. Her…
View article: Reviewer #2 (Public Review): Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Reviewer #2 (Public Review): Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: eLife Assessment: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
eLife Assessment: Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming Open
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of…
View article: eLife Assessment: Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity
eLife Assessment: Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity Open
Triglycerides (TG) in adipocytes provide the major stores of metabolic energy in the body. Optimal amounts of TG stores are desirable as insufficient capacity to store TG, as in lipodystrophy, or exceeding the capacity for storage, as in o…
View article: eLife Assessment: Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
eLife Assessment: Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Open
Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly…