Michael D. Bern
YOU?
Author Swipe
View article: Heterogeneity of immune escape mechanisms in de novo Acute Myeloid Leukemia
Heterogeneity of immune escape mechanisms in de novo Acute Myeloid Leukemia Open
Acute Myeloid Leukemia (AML) is a malignancy of hematopoietic stem/progenitor cells. Although immune checkpoint blockade has been effective for some cancers, this approach has had limited efficacy in AML patients. A better understanding of…
View article: NK cell licensing and missing self-recognition can be mediated by a single member of the Ly49 family 4220
NK cell licensing and missing self-recognition can be mediated by a single member of the Ly49 family 4220 Open
Description Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin…
View article: Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions
Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions Open
Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like recept…
View article: Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions
Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions Open
Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like recept…
View article: Expression of a single inhibitory Ly49 receptor is sufficient to license NK cells for effector functions
Expression of a single inhibitory Ly49 receptor is sufficient to license NK cells for effector functions Open
Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like recept…
View article: Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions
Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions Open
Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like recept…
View article: Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions
Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions Open
Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like recept…
View article: Immune Adjuvant Therapy With Interleukin-7 in a Lymphopenic Patient With Aplastic Anemia and Mucormycosis
Immune Adjuvant Therapy With Interleukin-7 in a Lymphopenic Patient With Aplastic Anemia and Mucormycosis Open
BACKGROUND: We report the case of a patient with aplastic anemia and pancytopenia on immune-suppressive therapy who developed invasive pulmonary infection with mucormycosis and was treated with immune adjuvant therapy. CASE SUMMARY: Given …
View article: The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function
The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function Open
BTB domain And CNC Homolog 2 (Bach2) is a transcription repressor that actively participates in T and B lymphocyte development, but it is unknown if Bach2 is also involved in the development of innate immune cells, such as natural killer (…
View article: The Transcription Factor Bach2 Negatively Regulates Natural Killer Cell Maturation and Function
The Transcription Factor Bach2 Negatively Regulates Natural Killer Cell Maturation and Function Open
BTB domain And CNC Homolog 2 (Bach2) is a transcription repressor that actively participates in T and B lymphocyte development, but it is unknown if Bach2 is also involved in the development of innate immune cells, such as natural killer (…
View article: In Vivo Mechanisms of Natural Killer Cell Tolerance
In Vivo Mechanisms of Natural Killer Cell Tolerance Open
Natural killer (NK) cells are cytotoxic innate immune cells that provide protection from pathogens and tumors. To carry out these functions, NK cells must distinguish between healthy and unhealthy self-cells. Inability to recognize stresse…
View article: Control of Viral Infection by Natural Killer Cell Inhibitory Receptors
Control of Viral Infection by Natural Killer Cell Inhibitory Receptors Open
Major histocompatibility complex class I (MHC-I)-restricted immune responses are largely attributed to cytotoxic T lymphocytes (CTLs). However, natural killer (NK) cells, as predicted by the missing-self hypothesis, have opposing requireme…
View article: Major histocompatibility complex class I-restricted protection against murine cytomegalovirus requires missing-self recognition by the natural killer cell inhibitory Ly49 receptors
Major histocompatibility complex class I-restricted protection against murine cytomegalovirus requires missing-self recognition by the natural killer cell inhibitory Ly49 receptors Open
Viruses have evolved strategies that highlight critical, intertwined host immune mechanisms. As postulated by the missing-self hypothesis, natural killer (NK) cells and major histocompatibility complex class I (MHC-I)-restricted cytotoxic …
View article: Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells
Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells Open
Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state. However, t…
View article: Author response: Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells
Author response: Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Innate lymphoid cells (ILCs) were original…
View article: <i>Toxoplasma gondii</i>Infection Drives Conversion of NK Cells into ILC1s
<i>Toxoplasma gondii</i>Infection Drives Conversion of NK Cells into ILC1s Open
Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state. However, t…
View article: Viral MHCI inhibition evades tissue-resident memory T cell formation and responses
Viral MHCI inhibition evades tissue-resident memory T cell formation and responses Open
Tissue-resident memory CD8+ T cells (TRMs) confer rapid protection and immunity against viral infections. Many viruses have evolved mechanisms to inhibit MHCI presentation in order to evade CD8+ T cells, suggesting that these mechanisms ma…
View article: Inducible down-regulation of MHC class I results in natural killer cell tolerance
Inducible down-regulation of MHC class I results in natural killer cell tolerance Open
Natural killer (NK) cells are innate lymphocytes that are thought to kill cells that down-regulate MHC class I (MHC-I) through “missing-self” recognition. NK cells from B2m−/− mice that lack surface MHC-I, however, are not autoreactive as …
View article: Immunoreceptor tyrosine-based inhibitory motif–dependent functions of an MHC class I-specific NK cell receptor
Immunoreceptor tyrosine-based inhibitory motif–dependent functions of an MHC class I-specific NK cell receptor Open
Significance Natural killer (NK) cells are cytotoxic immune cells that are regulated by inhibitory receptors, such as murine Ly49s, that bind to MHC class I (MHC-I). Cancer immunotherapies are currently in clinical trial that target inhibi…