Michael D. Chuong
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View article: Benchmarking Modern Day Pencil Beam Scanning Proton Therapy Treatment Times: Insights From Real Time Location Service Treatment Time Data
Benchmarking Modern Day Pencil Beam Scanning Proton Therapy Treatment Times: Insights From Real Time Location Service Treatment Time Data Open
View article: First Spanish Experience with Stereotactic MR-Guided Adaptive Radiotherapy (SMART) in Borderline Resectable and Locally Advanced Pancreatic Cancer: A Prospective Study
First Spanish Experience with Stereotactic MR-Guided Adaptive Radiotherapy (SMART) in Borderline Resectable and Locally Advanced Pancreatic Cancer: A Prospective Study Open
Background/Objectives: In Spain, pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of cancer-related death, with only 20% of patients eligible for surgery at diagnosis. For the remaining majority, prognosis is poor and e…
View article: The Role of MR Guided Radiation Therapy in Pancreatic Cancer Treatment
The Role of MR Guided Radiation Therapy in Pancreatic Cancer Treatment Open
View article: Multi-Institutional Comparison of Ablative 5-Fraction Magnetic Resonance-Guided Online Adaptive Versus 15/25-Fraction Computed Tomography-Guided Moderately Hypofractionated Offline Adapted Radiation Therapy for Locally Advanced Pancreatic Cancer
Multi-Institutional Comparison of Ablative 5-Fraction Magnetic Resonance-Guided Online Adaptive Versus 15/25-Fraction Computed Tomography-Guided Moderately Hypofractionated Offline Adapted Radiation Therapy for Locally Advanced Pancreatic Cancer Open
Background: Radiation dose escalation for locally advanced pancreatic cancer (LAPC) using stereotactic magnetic resonance (MR)-guided online adaptive radiation therapy (SMART) or computed tomography (CT)-guided moderately hypofractionated …
View article: Ablative Five-Fraction CT Versus MR-Guided Stereotactic Body Radiation Therapy for Pancreatic Cancer: In Silico Evaluation of Interfraction Anatomic Changes as a Rationale for Online Adaptive Replanning
Ablative Five-Fraction CT Versus MR-Guided Stereotactic Body Radiation Therapy for Pancreatic Cancer: In Silico Evaluation of Interfraction Anatomic Changes as a Rationale for Online Adaptive Replanning Open
Background/Objectives: Non-ablative stereotactic body radiation therapy (SBRT) is commonly employed for locally advanced pancreatic cancer (LAPC) using computed tomography-guided radiotherapy (CTgRT) without online adaptive radiation thera…
View article: Evolving Trends and Patterns of Utilization of Magnetic Resonance-Guided Radiotherapy at a Single Institution, 2018–2024
Evolving Trends and Patterns of Utilization of Magnetic Resonance-Guided Radiotherapy at a Single Institution, 2018–2024 Open
Background/Objectives: Over the past decade, significant advances have been made in image-guided radiotherapy (RT) particularly with the introduction of magnetic resonance (MR)-guided radiotherapy (MRgRT). However, the optimal clinical app…
View article: Tissue oxygenation flow differences in radiation therapy treated breast cancer subjects using near-infrared spectroscopy
Tissue oxygenation flow differences in radiation therapy treated breast cancer subjects using near-infrared spectroscopy Open
Purpose At least 95% of breast cancer patients treated with radiation therapy (RT) may experience radiation dermatitis (RD) and or skin hyperpigmentation (SH). Assessment of severity or grading of RD is clinically visual and hence subjecti…
View article: TCF4 as a potential prognostic biomarker and an anticancer target in gastric cancer
TCF4 as a potential prognostic biomarker and an anticancer target in gastric cancer Open
TCF4 potentially exerts a carcinogenic role in the progression of GC. TCF4 may serve as a prognostic indicator and therapeutic target for GC.
View article: Letter to the Editor
Letter to the Editor Open
View article: Case report: Intrafraction dose-guided tracking for gastrointestinal organ-at-risk isotoxicity delivery on an MR-guided radiotherapy system
Case report: Intrafraction dose-guided tracking for gastrointestinal organ-at-risk isotoxicity delivery on an MR-guided radiotherapy system Open
In the current era of high-precision radiation therapy, real-time magnetic resonance (MR)-guided tracking of the tumor and organs at risk (OARs) is a novel approach that enables accurate and safe delivery of high-dose radiation. Organ trac…
View article: Establishing Updated Safety Standards for Independent 99Tc-MAA SPECT/CT Treatment Planning in Radioembolization
Establishing Updated Safety Standards for Independent 99Tc-MAA SPECT/CT Treatment Planning in Radioembolization Open
This study demonstrated a safe method for translating dose limits from 99mTc-MAA planar imaging to SPECT/CT. A robust pretreatment protocol was further developed guided by the current knowledge in the field. Establish…
View article: PATTERNS OF PROTON BEAM THERAPY UTILIZATION ACROSS >30,000 PATIENTS IN THE PROTON COLLABORATIVE GROUP REG001-09 STUDY FROM 2009-2024
PATTERNS OF PROTON BEAM THERAPY UTILIZATION ACROSS >30,000 PATIENTS IN THE PROTON COLLABORATIVE GROUP REG001-09 STUDY FROM 2009-2024 Open
View article: Emerging potential of tumor treating fields as a treatment modality for pancreatic cancer: a narrative review of therapeutic evolution
Emerging potential of tumor treating fields as a treatment modality for pancreatic cancer: a narrative review of therapeutic evolution Open
Background and Objective: Pancreatic ductal adenocarcinoma (PDAC) is poorly responsive to conventional treatment and therefore is among the deadliest cancers. Tumor treating fields (TTFields) delivers low-intensity electrical fields that a…
View article: Quality assurance of an established online adaptive radiotherapy program: patch and software upgrade
Quality assurance of an established online adaptive radiotherapy program: patch and software upgrade Open
Introduction The ability to dynamically adjust target contours, derived Boolean structures, and ultimately, the optimized fluence is the end goal of online adaptive radiotherapy (ART). The purpose of this work is to describe the necessary …
View article: Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Pancreas
Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Pancreas Open
View article: PTCOG Gastrointestinal Subcommittee Lower Gastrointestinal Tract Malignancies Consensus Statement
PTCOG Gastrointestinal Subcommittee Lower Gastrointestinal Tract Malignancies Consensus Statement Open
PBT may be of significant value in select patients with LGI malignancies. Additional clinical data are needed to further elucidate the potential benefits of PBT for patients with anal cancer and rectal cancer.
View article: PD-1 inhibition combined with intensity-modulated radiotherapy, to better serve patients with retroperitoneal lymph node metastases from gastrointestinal cancer
PD-1 inhibition combined with intensity-modulated radiotherapy, to better serve patients with retroperitoneal lymph node metastases from gastrointestinal cancer Open
PD-1 inhibitors plus IMRT may be a better method for advanced GI cancer patients with RPLN metastases. HBV-positive patients can benefit from either PD-1 inhibitors alone or in combination with IMRT.
View article: Accelerated Hypofractionated Magnetic Resonance Guided Adaptive Radiation Therapy for Ultracentral Lung Tumors
Accelerated Hypofractionated Magnetic Resonance Guided Adaptive Radiation Therapy for Ultracentral Lung Tumors Open
Radiotherapy for ultracentral lung tumors represents a treatment challenge, considering the high rates of high-grade treatment-related toxicities with stereotactic body radiation therapy (SBRT) or hypofractionated schedules. Accelerated hy…
View article: Multi-institutional experience of MR-guided stereotactic body radiation therapy for adrenal gland metastases
Multi-institutional experience of MR-guided stereotactic body radiation therapy for adrenal gland metastases Open
We demonstrate that MRgSBRT achieves favorable early LC and no grade 3 + toxicity despite prescribing a median BED10 of 100 Gy to targets near GI OARs.
View article: Stereotactic MR-guided on-table adaptive radiation therapy (SMART) for borderline resectable and locally advanced pancreatic cancer: A multi-center, open-label phase 2 study
Stereotactic MR-guided on-table adaptive radiation therapy (SMART) for borderline resectable and locally advanced pancreatic cancer: A multi-center, open-label phase 2 study Open
View article: The First Report of Using Low-Field MRI-Guided Radiation Therapy in a Patient With a Cochlear Implant
The First Report of Using Low-Field MRI-Guided Radiation Therapy in a Patient With a Cochlear Implant Open
View article: Tumor treating fields: narrative review of a promising treatment modality for cancer
Tumor treating fields: narrative review of a promising treatment modality for cancer Open
Based on preclinical and clinical studies, TTFields therapy show promise as a potential treatment option for patients with a number of different malignancies, offering a favorable safety profile and the potential for significant clinical b…
View article: A multi-centric evaluation of self-learning GAN based pseudo-CT generation software for low field pelvic magnetic resonance imaging
A multi-centric evaluation of self-learning GAN based pseudo-CT generation software for low field pelvic magnetic resonance imaging Open
Purpose/objectives An artificial intelligence-based pseudo-CT from low-field MR images is proposed and clinically evaluated to unlock the full potential of MRI-guided adaptive radiotherapy for pelvic cancer care. Materials and method In co…
View article: AAPM Medical Physics Practice Guideline 14.a: Yttrium‐90 microsphere radioembolization
AAPM Medical Physics Practice Guideline 14.a: Yttrium‐90 microsphere radioembolization Open
Radioembolization using Yttrium‐90 ( 90 Y) microspheres is widely used to treat primary and metastatic liver tumors. The present work provides minimum practice guidelines for establishing and supporting such a program. Medical physicists p…
View article: Commissioning Intracranial Stereotactic Radiosurgery for a Magnetic Resonance-Guided Radiation Therapy (MRgRT) System: MR-RT Localization and Dosimetric End-to-End Validation
Commissioning Intracranial Stereotactic Radiosurgery for a Magnetic Resonance-Guided Radiation Therapy (MRgRT) System: MR-RT Localization and Dosimetric End-to-End Validation Open
All localization and dosimetric evaluation demonstrated submillimeter accuracy, per the TG-142, TG-101, MPPG 9.a. criteria for SRS/SRT systems, indicating acceptable delivery capabilities with a 1 mm setup margin.
View article: Online adaptive radiotherapy: Assessment of planning technique and its impact on longitudinal plan quality robustness in pancreatic cancer
Online adaptive radiotherapy: Assessment of planning technique and its impact on longitudinal plan quality robustness in pancreatic cancer Open
Planning on a static dataset that reflects the simulation day anatomy is routine for SBRT. We hypothesize the quality of on-table adaptive plans is similar to the baseline plan when delivering stereotactic MR-guided adaptive radiotherapy (…
View article: Advanced and emerging radiation therapy approaches for intrahepatic cholangiocarcinoma
Advanced and emerging radiation therapy approaches for intrahepatic cholangiocarcinoma Open
Radiotherapy (RT) is an integral component of the multidisciplinary care for intrahepatic cholangiocarcinoma (iCCA). Over the past decades, RT techniques have been developed with the aim of enhancing tumor control and minimizing toxicity. …
View article: A Multi-Institutional Phase 2 Trial of Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided On-Table Adaptive Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer
A Multi-Institutional Phase 2 Trial of Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided On-Table Adaptive Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer Open
View article: Neoadjuvant chemotherapy and stereotactic body radiation therapy for borderline resectable pancreas adenocarcinoma: influence of vascular margin status and type of chemotherapy
Neoadjuvant chemotherapy and stereotactic body radiation therapy for borderline resectable pancreas adenocarcinoma: influence of vascular margin status and type of chemotherapy Open
For BRPC, the effect of a positive or close vascular margin may be mitigated by neoadjuvant therapy. Shorter duration neoadjuvant chemotherapy as well as the optimal biological effective dose of radiotherapy should be prospectively explore…
View article: Methodological Considerations When Using Polygenic Scores to Explore Parent-Offspring Genetic Nurturing Effects
Methodological Considerations When Using Polygenic Scores to Explore Parent-Offspring Genetic Nurturing Effects Open
Background Research has begun to explore the effects of parental genetic nurturing on offspring outcomes using polygenic scores (PGSs). However, there are concerns regarding potential biases due to confounding when mediating parental pheno…