Michael D. Cole
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View article: Rapidly progressive acute chest syndrome is associated with complement-mediated cell injury in adults with sickle cell disease
Rapidly progressive acute chest syndrome is associated with complement-mediated cell injury in adults with sickle cell disease Open
Introduction Rapidly progressive acute chest syndrome (RP-ACS) is a distinct phenotype of acute chest syndrome, characterized by rapid progression of respiratory compromise, with respiratory failure within 24 hours of the onset of respirat…
View article: NLRP3 inflammasome inhibition fails to prevent red blood cell lysis in PNH
NLRP3 inflammasome inhibition fails to prevent red blood cell lysis in PNH Open
Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated red blood cell (RBC) lysis due to acquired deficiencies in complement regulatory proteins. A recent study in “Cell” (Chen et al., Cell, 2025) p…
View article: Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS)
Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS) Open
Objective Catastrophic antiphospholipid syndrome (CAPS), characterized by widespread thrombosis and multi-organ failure, is associated with high morbidity and mortality. We previously established complement activation as a pathogenic drive…
View article: A novel somato-visual functional connectivity biomarker for affective and non-affective psychosis
A novel somato-visual functional connectivity biomarker for affective and non-affective psychosis Open
View article: Issue Information
Issue Information Open
View article: Supplemental Information from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Information from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
Description of supplemental data
View article: Supplemental Figure S6 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S6 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
Immunoprecipitation of XPB, MYC, TIP60, CDK7, or MRG15 from IMEC:MYC cells. Co-immunoprecipitated proteins detected using Western blot.
View article: Data from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Data from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
MYC is a pleiotropic transcription factor that activates and represses a wide range of target genes and is frequently deregulated in human tumors. While much is known about the role of MYC in transcriptional activation and repression, MYC …
View article: Data from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Data from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
MYC is a pleiotropic transcription factor that activates and represses a wide range of target genes and is frequently deregulated in human tumors. While much is known about the role of MYC in transcriptional activation and repression, MYC …
View article: Supplemental data from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk
Supplemental data from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk Open
Figure legends for Supplemental Figures 1 and 2
View article: Supplemental Figure S3 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S3 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
MYC-mediated mRNA cap methylation of MAX transcripts.
View article: Supplemental Figure S5 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S5 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
TFIIH, specifically CDK7, promotes mRNA cap methylation of canonical Wnt/beta-catenin signaling pathway transcripts.
View article: Supplemental Figure 1 from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk
Supplemental Figure 1 from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk Open
S1. KLF5 binds the CCNE1 intronic region and contributes to CCNE1 expression in the J82 UBC cell line.
View article: Data from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk
Data from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk Open
It is well established that environmental toxins, such as exposure to arsenic, are risk factors in the development of urinary bladder cancer, yet recent genome-wide association studies (GWAS) provide compelling evidence that there is a str…
View article: Supplemental Figure S4 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S4 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
MYC promotes Wnt signaling activity in part by enhancing mRNA cap methylation.
View article: Supplemental Figure S1 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S1 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
Schematic and validation of methyl-capped (m7G) mRNA pulldown.
View article: Supplemental Figure 2 from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk
Supplemental Figure 2 from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk Open
S2. KLF5 promotes enhanced activity on the high risk versus low risk allele.
View article: Supplemental Figure 1 from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk
Supplemental Figure 1 from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk Open
S1. KLF5 binds the CCNE1 intronic region and contributes to CCNE1 expression in the J82 UBC cell line.
View article: Supplemental Figure S2 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S2 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
Global total mRNA expression in P493-6 cells with varying MYC levels and validation in HO rat fibroblasts and IMEC cells.
View article: Data from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk
Data from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk Open
It is well established that environmental toxins, such as exposure to arsenic, are risk factors in the development of urinary bladder cancer, yet recent genome-wide association studies (GWAS) provide compelling evidence that there is a str…
View article: Supplemental Figure S1 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S1 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
Schematic and validation of methyl-capped (m7G) mRNA pulldown.
View article: Supplemental Figure S2 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S2 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
Global total mRNA expression in P493-6 cells with varying MYC levels and validation in HO rat fibroblasts and IMEC cells.
View article: Supplemental Figure S5 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S5 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
TFIIH, specifically CDK7, promotes mRNA cap methylation of canonical Wnt/beta-catenin signaling pathway transcripts.
View article: Supplemental Figure S6 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S6 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
Immunoprecipitation of XPB, MYC, TIP60, CDK7, or MRG15 from IMEC:MYC cells. Co-immunoprecipitated proteins detected using Western blot.
View article: Supplemental Figure 2 from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk
Supplemental Figure 2 from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk Open
S2. KLF5 promotes enhanced activity on the high risk versus low risk allele.
View article: Supplemental data from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk
Supplemental data from Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk Open
Figure legends for Supplemental Figures 1 and 2
View article: Supplemental Figure S4 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S4 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
MYC promotes Wnt signaling activity in part by enhancing mRNA cap methylation.
View article: Supplemental Figure S3 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Figure S3 from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
MYC-mediated mRNA cap methylation of MAX transcripts.
View article: Supplemental Information from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Supplemental Information from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase Open
Description of supplemental data
View article: Supplementary Figure S4 from Genetic Variation and Recurrent Haplotypes on Chromosome 6q23-25 Risk Locus in Familial Lung Cancer
Supplementary Figure S4 from Genetic Variation and Recurrent Haplotypes on Chromosome 6q23-25 Risk Locus in Familial Lung Cancer Open
Supplementary Figure S4: Segregation of potential causal variants in MAP3K4 in families 42 and 44. In both pedigrees, gray symbols represent non-affected individuals (coded as missing in the analysis) and black symbol represent affected in…