Michael D. Kornberg
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View article: 2-Deoxy-D-Glucose restores glial cell mitochondrial function and attenuates neuroinflammation
2-Deoxy-D-Glucose restores glial cell mitochondrial function and attenuates neuroinflammation Open
Neuroinflammation plays a central role in a wide spectrum of neurological diseases, driven generally by reactive microglia and astrocytes. Inflammatory stimulation of microglia and astrocytes leads to a metabolic shift from oxidative phosp…
View article: Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism Open
The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation. In this study, we focused on the regulatory…
View article: Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism Open
The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation. In this study, we focused on the regulatory…
View article: Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism Open
The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation. In this study, we focused on the regulatory…
View article: Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism Open
The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation. In this study, we focused on the regulatory…
View article: Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation
Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation Open
In multiple sclerosis (MS) the circulating metabolome is dysregulated, with indole lactate (ILA) being one of the most significantly reduced metabolites. We demonstrate that oral supplementation of ILA impacts key MS disease processes in t…
View article: Meningeal Dissemination and Drop Metastasis From Glioma Presenting With Non-Epileptic Myoclonus and Minipolymyoclonus
Meningeal Dissemination and Drop Metastasis From Glioma Presenting With Non-Epileptic Myoclonus and Minipolymyoclonus Open
We describe the case of a 36-year-old woman with a past medical history of low grade right frontal lobe glioma and focal epilepsy presenting with subacute, progressive, multifocal myoclonus and neck and back pain. Unlike her typical seizur…
View article: Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism Open
The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation. In this study, we focused on the regulatory…
View article: TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis
TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis Open
Protein kinase C (PKC) plays a key role in modulating the activities of the innate immune cells of the central nervous system (CNS). A delicate balance between pro-inflammatory and regenerative activities by microglia and CNS-associated ma…
View article: TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis
TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis Open
Protein kinase C (PKC) plays a key role in modulating the activities of the innate immune cells of the central nervous system (CNS). A delicate balance between pro-inflammatory and regenerative activities by microglia and CNS-associated ma…
View article: PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination
PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination Open
In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining the balance between myelin repair and demyelination/neurodegeneration. Phagocytic and regenerative function…
View article: Inhibition of distinct glycolytic enzymes produces differential effects on CD4 T cell function
Inhibition of distinct glycolytic enzymes produces differential effects on CD4 T cell function Open
Introduction When T cells are activated, they upregulate glycolysis and take on a requisite Warburg phenotype. In this study, we evaluated the effect of inhibiting two distinct glycolytic enzymes, GAPDH and PGAM, on CD4 T cell differentiat…
View article: Therapeutic potential of blocking GAPDH nitrosylation with CGP3466b in experimental autoimmune encephalomyelitis
Therapeutic potential of blocking GAPDH nitrosylation with CGP3466b in experimental autoimmune encephalomyelitis Open
Multiple sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS). Although classically considered a demyelinating disease, neuroaxonal injury occurs in both the acute and chronic phases and represents a pathologic…
View article: Therapeutic Potential of Blocking GAPDH Nitrosylation with CGP3466b in Experimental Autoimmune Encephalomyelitis
Therapeutic Potential of Blocking GAPDH Nitrosylation with CGP3466b in Experimental Autoimmune Encephalomyelitis Open
Multiple sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS). Although classically considered a demyelinating disease, neuroaxonal injury occurs in both the acute and chronic phases and represents a pathologic…
View article: Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling
Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling Open
Synapses connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. Synaptic function and plasticity, the neuronal process of adapting to diverse and variable inputs, depend on the dynamic natu…
View article: Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling
Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling Open
Significance Inositol pyrophosphates are versatile messenger molecules containing the energetic pyrophosphate bond. One of the principal enzymes generating the inositol pyrophosphate IP 7 (5-diphosphoinositolpentakisphosphate) is inositol …
View article: Intermittent calorie restriction alters T cell subsets and metabolic markers in people with multiple sclerosis
Intermittent calorie restriction alters T cell subsets and metabolic markers in people with multiple sclerosis Open
Background: Intermittent fasting or calorie restriction (CR) diets provide anti-inflammatory and neuroprotective advantages in models of multiple sclerosis (MS); data in humans are sparse. Methods: We conducted a randomized-controlled feed…
View article: D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain
D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain Open
Significance d -amino acids are increasingly recognized as important signaling molecules in the mammalian central nervous system. Cysteine is the amino acid with the fastest in vitro spontaneous racemization rate, but its d -stereoisomer h…
View article: COVID-19 and Vaccination in the Setting of Neurologic Disease
COVID-19 and Vaccination in the Setting of Neurologic Disease Open
The COVID-19 pandemic caused by the SARS-CoV-2 virus has left many unanswered questions for patients with neurological disorders and the providers caring for them. Elderly and immunocompromised patients are at increased risk for severe sym…
View article: Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B
Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B Open
Significance Inositol hexakisphosphate kinase 2 (IP6K2) regulates various cellular processes. Here we establish a role for IP6K2 in the brain. IP6K2 deletion leads to impaired mitochondrial function and repression of the cytochrome c1 subu…
View article: Multi-omic Evaluation of Metabolic Alterations in Multiple Sclerosis Identifies Shifts in Aromatic Amino Acid Metabolism
Multi-omic Evaluation of Metabolic Alterations in Multiple Sclerosis Identifies Shifts in Aromatic Amino Acid Metabolism Open
The circulating metabolome is a product of interactions between the genome, epigenome, exposome and microbiome. The metabolome may be altered in people with multiple sclerosis (MS); however, existing metabolomics studies were relatively sm…
View article: The Role of Metabolic Enzymes in the Regulation of Inflammation
The Role of Metabolic Enzymes in the Regulation of Inflammation Open
Immune cells undergo dramatic metabolic reprogramming in response to external stimuli. These metabolic pathways, long considered as simple housekeeping functions, are increasingly understood to critically regulate the immune response, dete…
View article: Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation
Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation Open
SUMMARY Neuroinflammation characterizes multiple neurologic diseases, including primary inflammatory conditions such as multiple sclerosis (MS) and classical neurodegenerative diseases. Aberrant activation of the innate immune system contr…