Michael D. Lewis
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View article: Biparental Inheritance and Instability of kDNA in Experimental Hybrids of Trypanosoma cruzi: A Proposal for a Mechanism
Biparental Inheritance and Instability of kDNA in Experimental Hybrids of Trypanosoma cruzi: A Proposal for a Mechanism Open
The mitochondrial DNA of trypanosomatid parasites consists of thousands of catenated minicircles and dozens of maxicircles that form a complex network structure, the kinetoplast (kDNA). Although kDNA replication and segregation during mito…
View article: Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease
Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease Open
Background There is an urgent need for improved treatments for Chagas disease, a neglected tropical infection caused by the protozoan parasite Trypanosoma cruzi . Benznidazole, the first line therapy, has severe limitations such as poor to…
View article: Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease
Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease Open
Infections with Trypanosoma cruzi cause Chagas disease, a chronic condition that can give rise to debilitating cardiac and/or gastrointestinal damage. However, it is unclear why only ~30% of individuals progress to symptomatic pathology, w…
View article: Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease
Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease Open
Infections with Trypanosoma cruzi cause Chagas disease, a chronic condition that can give rise to debilitating cardiac and/or gastrointestinal damage. However, it is unclear why only ∼30% of individuals progress to symptomatic pathology, w…
View article: Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction
Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction Open
Chagas disease is a zoonosis caused by the protozoan parasite Trypanosoma cruzi . Clinical outcomes range from long-term asymptomatic carriage to cardiac, digestive, neurological and composite presentations that can be fatal in both acute …
View article: A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research
A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research Open
Chagas disease is caused by Trypanosoma cruzi , a protozoan parasite that displays considerable genetic diversity. Infections result in a range of pathological outcomes, and different strains can exhibit a wide spectrum of anti-parasitic d…
View article: Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy
Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy Open
View article: A panel of phenotypically and genotypically diverse bioluminescent:fluorescent<i>Trypanosoma cruzi</i>strains as a resource for Chagas disease research
A panel of phenotypically and genotypically diverse bioluminescent:fluorescent<i>Trypanosoma cruzi</i>strains as a resource for Chagas disease research Open
Chagas disease is caused by Trypanosoma cruzi , a protozoan parasite that displays considerable genetic diversity. Infections result in a range of pathological outcomes, and different strains can exhibit a wide spectrum of anti-parasitic d…
View article: Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease
Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease Open
Chronic Chagas cardiomyopathy (CCC) results from infection with the protozoan parasite Trypanosoma cruzi and is a prevalent cause of heart disease in endemic countries. We previously found that cardiac fibrosis can vary widely in C3H/HeN m…
View article: Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice Open
Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi , the causative agent of Chagas disease. However, for reasons that are unknown, treatment failures are common. When we examined parasites that survived ben…
View article: Dynamics of<i>Trypanosoma cruzi</i>infection in hamsters and novel association with progressive motor dysfunction
Dynamics of<i>Trypanosoma cruzi</i>infection in hamsters and novel association with progressive motor dysfunction Open
Chagas disease is a zoonosis caused by the protozoan parasite Trypanosoma cruzi. Clinical outcomes range from long-term asymptomatic carriage to cardiac, digestive, neurological and composite presentations that can be fatal in both acute a…
View article: Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease
Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease Open
Chronic Chagas Cardiomyopathy (CCC) results from infection with the protozoan parasite Trypanosoma cruzi and is a prevalent cause of heart disease in endemic countries. We previously found that cardiac fibrosis can vary widely in C3H/HeN m…
View article: <i>Trypanosoma cruzi</i>persisters that survive benznidazole treatment<i>in vitro</i>and<i>in vivo</i>are in a transient non-replicative state
<i>Trypanosoma cruzi</i>persisters that survive benznidazole treatment<i>in vitro</i>and<i>in vivo</i>are in a transient non-replicative state Open
Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi , the causative agent of Chagas disease. However, for reasons that are unknown, treatment failures are common. To assess the nature of parasites that persi…
View article: Study on emotion recognition bias in different regional groups
Study on emotion recognition bias in different regional groups Open
Human-machine communication can be substantially enhanced by the inclusion of high-quality real-time recognition of spontaneous human emotional expressions. However, successful recognition of such expressions can be negatively impacted by …
View article: Study on Emotion Recognition Bias in Different Regional Groups
Study on Emotion Recognition Bias in Different Regional Groups Open
Human-machine communication can be substantially enhanced by the inclusion of high-quality real-time recognition of spontaneous emotional expressions. However, successful recognition of such expressions can be negatively impacted by factor…
View article: Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy
Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy Open
Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. There is a lack of evidence on the mechanism of pathogenesis and rationales for treatment. We used a mouse model that recapitulates key clinical…
View article: Study on Emotion Recognition Bias in Different Regional Groups
Study on Emotion Recognition Bias in Different Regional Groups Open
Human-machine communication can be substantially enhanced by the inclusion of high-quality real-time recognition of spontaneous emotional expressions. However, successful recognition of such expressions can be negatively impacted by factor…
View article: Impact of Visceral Leishmaniasis on Local Organ Metabolism in Hamsters
Impact of Visceral Leishmaniasis on Local Organ Metabolism in Hamsters Open
Leishmania is an intracellular parasite with different species pathogenic to humans and causing the disease leishmaniasis. Leishmania donovani causes visceral leishmaniasis (VL) that manifests as hepatosplenomegaly, fever, pancytopenia and…
View article: Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification
Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification Open
Protozoa and fungi are known to have extraordinarily diverse mechanisms of genetic exchange. However, the presence and epidemiological relevance of genetic exchange in Trypanosoma cruzi , the agent of Chagas disease, has been controversial…
View article: Author response: Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification
Author response: Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Protozoa and fungi are…
View article: Experimental microevolution of <i>Trypanosoma cruzi</i> reveals hybridization and clonal mechanisms driving rapid diversification of genome sequence and structure
Experimental microevolution of <i>Trypanosoma cruzi</i> reveals hybridization and clonal mechanisms driving rapid diversification of genome sequence and structure Open
Protozoa and fungi are known to have extraordinarily diverse mechanisms of genetic exchange. However, the presence and epidemiological relevance of genetic exchange in Trypanosoma cruzi , the agent of Chagas disease, has been controversial…
View article: A Vaccination Simulator for COVID-19: Effective and Sterilizing Immunization Cases
A Vaccination Simulator for COVID-19: Effective and Sterilizing Immunization Cases Open
In this work, we present a particle-based SEIR epidemic simulator as a tool to assess the impact of different vaccination strategies on viral propagation and to model sterilizing and effective immunization outcomes. The simulator includes …
View article: Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale
Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale Open
Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. The mechanism of pathogenesis is poorly understood and the lack of a robust, predictive animal model has held back research. We screened a serie…
View article: SpeakingFaces: A Large-Scale Multimodal Dataset of Voice Commands with Visual and Thermal Video Streams
SpeakingFaces: A Large-Scale Multimodal Dataset of Voice Commands with Visual and Thermal Video Streams Open
We present SpeakingFaces as a publicly-available large-scale multimodal dataset developed to support machine learning research in contexts that utilize a combination of thermal, visual, and audio data streams; examples include human–comput…
View article: SpeakingFaces: A Large-Scale Multimodal Dataset of Voice Commands with Visual and Thermal Video Streams
SpeakingFaces: A Large-Scale Multimodal Dataset of Voice Commands with Visual and Thermal Video Streams Open
We present SpeakingFaces as a publicly-available large-scale multimodal dataset developed to support machine learning research in contexts that utilize a combination of thermal, visual, and audio data streams; examples include human–comput…
View article: Local association of<i>Trypanosoma cruzi</i>chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale
Local association of<i>Trypanosoma cruzi</i>chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale Open
Gastrointestinal (GI) disease affects a substantial subset of chronic Chagas disease (CD) patients, but the mechanism of pathogenesis is poorly understood. The lack of a robust, predictive animal model of chronic T. cruzi infection that ex…
View article: Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi
Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi Open
Trypanosoma cruzi , a zoonotic kinetoplastid protozoan parasite, is the causative agent of American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex genome, the parasite displays a highly diverse repertoire o…
View article: Incomplete recruitment of protective T cells facilitates<i>Trypanosoma cruzi</i>persistence in the mouse colon
Incomplete recruitment of protective T cells facilitates<i>Trypanosoma cruzi</i>persistence in the mouse colon Open
Trypanosoma cruzi is the etiological agent of Chagas disease. Following T cell mediated suppression of the acute phase infection, this intracellular eukaryotic pathogen persists in a limited sub-set of tissues at extremely low-levels. The …
View article: Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity
Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity Open
Analysis of genetic polymorphism is a powerful tool for epidemiological surveillance and research. Powerful inference from pathogen genetic variation, however, is often restrained by limited access to representative target DNA, especially …
View article: Host‐parasite dynamics in Chagas disease from systemic to hyper‐local scales
Host‐parasite dynamics in Chagas disease from systemic to hyper‐local scales Open
Trypanosoma cruzi is a remarkably versatile parasite. It can parasitize almost any nucleated cell type and naturally infects hundreds of mammal species across much of the Americas. In humans, it is the cause of Chagas disease, a set of mai…