Michael D. Mandler
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View article: A General Redox-Neutral Platform for Radical Cross-Coupling
A General Redox-Neutral Platform for Radical Cross-Coupling Open
Sulfonyl hydrazides are disclosed as versatile radical precursors as exemplified with seven new C–C bond forming, redox neutral cross-couplings with: (1) unsaturated olefins, (2) alkyl halides, (3) redox active esters, (4) aryl halides, (5…
View article: Gabriel Synthesis of Aminomethyl-Bicyclo[1.1.0]butanes
Gabriel Synthesis of Aminomethyl-Bicyclo[1.1.0]butanes Open
The reaction of iodo-bicyclo[1.1.1]pentanes with potassium phthalimide yields phthalimide-substituted bicyclo[1.1.0]butanes (BCBs), which upon hydrazinolysis afford the corresponding aminomethyl-BCB products.
View article: CCDC 2079775: Experimental Crystal Structure Determination
CCDC 2079775: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O–H Activation and Lewis Acid-Catalyzed Fluoride Shuttling
Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O–H Activation and Lewis Acid-Catalyzed Fluoride Shuttling Open
A method for deoxyfluorination of aliphatic primary, secondary, and tertiary alcohols is reported, employing a nontrigonal phosphorus triamide for base-free alcohol activation in conjunction with an organic soluble fluoride donor and a tri…
View article: Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers
Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers Open
There is a pressing need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl frag-ments to (hetero)aryl halides. Herein a uniquely powerful and simple set of conditions for a…
View article: Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers
Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers Open
There is an urgent need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to (hetero)aryl halides. This early disclosure serves this purpose by informing the comm…
View article: CCDC 2259736: Experimental Crystal Structure Determination
CCDC 2259736: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2259735: Experimental Crystal Structure Determination
CCDC 2259735: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes
Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes Open
We describe a two step process for the synthesis of substituted bicyclo[1.1.0]butanes. A photo-Hunsdiecker reaction generates iodo-bicyclo[1.1.1]pentanes under metal-free conditions at room temperature. These intermediates react with nitro…
View article: Synthesis of Bicyclo[1.1.0]butanes from Bicyclo[1.1.1]pentanes
Synthesis of Bicyclo[1.1.0]butanes from Bicyclo[1.1.1]pentanes Open
We describe a two step process for the synthesis of substituted bicyclo[1.1.0]butanes. A photo-Hunsdiecker reaction generates iodo-bicyclo[1.1.1]pentanes under metal-free conditions at room temperature. These intermediates react with amine…
View article: Radical Simplification of Complex Molecule Retrosynthesis Enabled by Electrocatalytic Cross-Coupling of α-Substituted Carboxylic Acids
Radical Simplification of Complex Molecule Retrosynthesis Enabled by Electrocatalytic Cross-Coupling of α-Substituted Carboxylic Acids Open
The polar retrosynthetic analysis has been widely employed in the field of organic synthesis and forms the basis of undergraduate curriculum. Although most reactions in organic synthesis rely on this rubric to guide their strategic applica…
View article: CCDC 2196128: Experimental Crystal Structure Determination
CCDC 2196128: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2196127: Experimental Crystal Structure Determination
CCDC 2196127: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2184505: Experimental Crystal Structure Determination
CCDC 2184505: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis
Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis Open
A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero)arenes is reported. This pragmatically focused study employs a unique Ag-Ni electrocatalytic p…
View article: Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen
Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen Open
An open-air method for the transition metal-free direct amination of nitro(hetero)arenes by anilines is disclosed. In this methodology, an aromatic C-H bond is substituted via oxidative nucleophilic aromatic substitution of hydrogen (ONSH)…
View article: Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis
Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis Open
A useful protocol for achieving decarboxylative cross coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero)arenes is reported. This pragmatically focused study employs a unique Ag-Ni electrocatalytic p…
View article: CCDC 2110939: Experimental Crystal Structure Determination
CCDC 2110939: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2110937: Experimental Crystal Structure Determination
CCDC 2110937: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2110938: Experimental Crystal Structure Determination
CCDC 2110938: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2110935: Experimental Crystal Structure Determination
CCDC 2110935: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2110936: Experimental Crystal Structure Determination
CCDC 2110936: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Virtual Screening for Ligand Discovery at the σ<sub>1</sub> Receptor
Virtual Screening for Ligand Discovery at the σ<sub>1</sub> Receptor Open
The σ1 receptor is a transmembrane protein implicated in several pathophysiological conditions, including neurodegenerative disease (J. Pharmacol. Sci.2015127 (1), 1729), drug addiction (Behav. Pharmacol.201627 (2-3 Spec Issue), 10015), ca…
View article: Chemical Security Education Could Reduce Diversion, Misuse, and Errors in Hospital Settings in the United States
Chemical Security Education Could Reduce Diversion, Misuse, and Errors in Hospital Settings in the United States Open
Modern hospitals and healthcare clinics contain vast arsenals of dangerous drugs that have the potential for serious abuse and error if not properly stored, handled, and disposed of. In this commentary, we discuss drug-handling practices t…
View article: Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion
Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion Open
Significance The outer membrane of Gram-negative bacteria, mitochondria, and chloroplasts contains proteins that adopt β-barrel structures. To maintain the integrity of this structure, the β-barrel assembly machine (Bam) folds and inserts …
View article: CCDC 1854682: Experimental Crystal Structure Determination
CCDC 1854682: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport
The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport Open
Novobiocin is an orally active antibiotic that inhibits DNA gyrase by binding the ATP-binding site in the ATPase subunit. Although effective against Gram-positive pathogens, novobiocin has limited activity against Gram-negative organisms d…