Michael D. Tarpey
YOU?
Author Swipe
View article: Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle
Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle Open
The various functions of skeletal muscle (movement, respiration, thermogenesis, etc.) require the presence of oxygen (O2). Inadequate O2 bioavailability (ie, hypoxia) is detrimental to muscle function and, in chronic cases, can result in m…
View article: Complementary Square-Wave Voltammetry and LC-MS/MS Analysis to Elucidate Induced Damaged and Mutated Mitochondrial and Nuclear DNA from in Vivo Knockdown of the <i>BRCA</i>1 Gene in the Mouse Skeletal Muscle
Complementary Square-Wave Voltammetry and LC-MS/MS Analysis to Elucidate Induced Damaged and Mutated Mitochondrial and Nuclear DNA from in Vivo Knockdown of the <i>BRCA</i>1 Gene in the Mouse Skeletal Muscle Open
Breast cancer 1 gene (BRCA1) DNA mutations impact skeletal muscle functions. Inducible skeletal muscle specific Brca1 homozygote knockout (Brca1KOsmi, KO) mice accumulate mitochondrial DNA (mtDNA) mutations resulting in loss of …
View article: Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability
Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability Open
Breast Cancer gene 1 (BRCA1) is a large, multifunctional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nu…
View article: PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb
PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb Open
Compromised muscle mitochondrial metabolism is a hallmark of peripheral arterial disease, especially in patients with the most severe clinical manifestation - critical limb ischemia (CLI). We asked whether inflexibility in metabolism is cr…
View article: Increased Adenosine Monophosphate Degradation Impairs Mitochondrial Function
Increased Adenosine Monophosphate Degradation Impairs Mitochondrial Function Open
Click the PDF icon to download the abstract.
View article: Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation
Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation Open
Collectively, these results suggest that ERα function is superfluous in protecting against HFD-induced skeletal muscle metabolic derangements after postnatal development is complete.
View article: Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short term high fat diet in humans
Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short term high fat diet in humans Open
View article: Doxorubicin causes lesions in the electron transport system of skeletal muscle mitochondria that are associated with a loss of contractile function
Doxorubicin causes lesions in the electron transport system of skeletal muscle mitochondria that are associated with a loss of contractile function Open
View article: International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing
International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing Open
Background In this Position Statement, the International Society of Sports Nutrition (ISSN) provides an objective and critical review of the literature pertinent to nutritional considerations for training and racing in single-stage ultra-m…
View article: Induced <i>in vivo</i> knockdown of the <i>Brca1</i> gene in skeletal muscle results in skeletal muscle weakness
Induced <i>in vivo</i> knockdown of the <i>Brca1</i> gene in skeletal muscle results in skeletal muscle weakness Open
Key points Breast cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility protein (BRCA1). The gene is prone to mutations that cause a loss of protein function. BRCA1/Brca1 has recently been found to …
View article: Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants
Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants Open
The most severe manifestation of peripheral arterial disease (PAD) is critical limb ischemia (CLI). CLI patients suffer high rates of amputation and mortality; accordingly, there remains a clear need both to better understand CLI and to de…
View article: Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function
Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function Open
The results highlight the experimental flexibility afforded the investigator by using the FDB muscle to assess mechanisms that regulate skeletal muscle function.
View article: MP09-11 MARKED INCREASE IN MITOCHONDRIAL RESPIRATION, HYDROGEN PEROXIDE EMITTING POTENTIAL AND ATP PRODUCTION IN THE UROTHELIUM VERSUS DETRUSOR SMOOTH MUSCLE
MP09-11 MARKED INCREASE IN MITOCHONDRIAL RESPIRATION, HYDROGEN PEROXIDE EMITTING POTENTIAL AND ATP PRODUCTION IN THE UROTHELIUM VERSUS DETRUSOR SMOOTH MUSCLE Open
You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology I1 Apr 2018MP09-11 MARKED INCREASE IN MITOCHONDRIAL RESPIRATION, HYDROGEN PEROXIDE EMITTING POTENTIAL AND ATP PRODUCTION IN THE UROTHELIUM VERSUS DETRUS…
View article: Strain-Dependent Variation in Acute Ischemic Muscle Injury
Strain-Dependent Variation in Acute Ischemic Muscle Injury Open
View article: Induced Cre‐mediated knockdown of Brca1 in skeletal muscle reduces mitochondrial respiration and prevents glucose intolerance in adult mice on a high‐fat diet
Induced Cre‐mediated knockdown of Brca1 in skeletal muscle reduces mitochondrial respiration and prevents glucose intolerance in adult mice on a high‐fat diet Open
The breast cancer type 1 susceptibility protein (Brca1) is a regulator of DNA repair in mammary gland cells; however, recent cell culture evidence suggests that Brca1 influences other processes, including those in nonmammary cells. In this…
View article: Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms
Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms Open
Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms
View article: Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms
Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms Open
While α‐actin isoforms predominate in adult striated muscle, skeletal muscle‐specific knockouts (KOs) of nonmuscle cytoplasmic β cyto ‐ or γ cyto ‐actin each cause a mild, but progressive myopathy effected by an unknown mechanism. Using tr…
View article: Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal
Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal Open
In summary, mitophagy may be enhanced in endurance-trained runners based on elevated markers of mitophagy and mitochondrial dynamics. The HFM did not alter autophagy or mitophagy in either group. The absence of a relationship between mitop…
View article: <i>Exercise. Eat. Repeat</i>. Focus on “Prior exercise training blunts short-term high-fat diet-induced weight gain”
<i>Exercise. Eat. Repeat</i>. Focus on “Prior exercise training blunts short-term high-fat diet-induced weight gain” Open
View article: Skeletal muscle autophagy and mitophagy in response to high-fat feeding and endurance training
Skeletal muscle autophagy and mitophagy in response to high-fat feeding and endurance training Open
Obesity is associated with reduced skeletal muscle insulin sensitivity, a major risk factor for development of type II diabetes. These metabolic diseases are commonly associated with an accumulation of mitochondrial dysfunction, which is s…
View article: The effect of a decaffeinated green tea extract formula on fat oxidation, body composition and exercise performance
The effect of a decaffeinated green tea extract formula on fat oxidation, body composition and exercise performance Open
A 4 week dGTE intervention favourably enhanced substrate utilisation and subsequent performance indices, but did not alter TFA concentrations in comparison to PL. The results support the use of catechin polyphenols from dGTE in combination…