Michael D. Walla
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View article: Cyclopropanol - A Caged Dual-Functional Warhead for Selective Electrochemical Bioconjugation
Cyclopropanol - A Caged Dual-Functional Warhead for Selective Electrochemical Bioconjugation Open
Bioorthogonal reactions are powerful tools for studying and manipulating biological systems, yet achieving precise spatial and temporal control remains a major challenge. Here, we introduce cyclopropanol (CPol) as a compact, energy-loaded …
View article: Conformational Plasticity Enhances the Brain Penetration of a Metabolically Stable, Dual-Functional Opioid-Peptide CycloAnt
Conformational Plasticity Enhances the Brain Penetration of a Metabolically Stable, Dual-Functional Opioid-Peptide CycloAnt Open
CycloAnt is an opioid peptide that produces potent and efficacious antinociception with significantly reduced side effects upon systemic administration in mice. To verify its CNS-mediated antinociception, we determined its binding affinity…
View article: Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes
Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes Open
Bacterial natural product biosynthetic genes, canonically clustered, have been increasingly found to rely on hidden enzymes encoded elsewhere in the genome for completion of biosynthesis. The study and application of lanthipeptides are fre…
View article: Supplementary dataset for Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes
Supplementary dataset for Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes Open
Supplementary files for the paper: Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes 23777967_protease.fasta.xz: A fasta file (compressed by xz) containing 23777967 protease sequences obtained fr…
View article: Supplementary dataset for Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes
Supplementary dataset for Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes Open
Supplementary files for the paper: Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes 23777967_protease.fasta.xz: A fasta file (compressed by xz) containing 23777967 protease sequences obtained fr…
View article: Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes
Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes Open
Bacterial natural product biosynthetic genes, canonically clustered, have been increasingly found to rely on cryptic enzymes encoded elsewhere in the genome for completion of biosynthesis. The study and application of lanthipeptides are fr…
View article: Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis
Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis Open
Background and Aims Cannabinoid receptor [CB] activation can attenuate inflammatory bowel disease [IBD] in experimental models and human cohorts. However, the roles of the microbiome, metabolome, and the respective contributions of haemato…
View article: Defective Function of α-Ketoglutarate Dehydrogenase Exacerbates Mitochondrial ATP Deficits during Complex I Deficiency
Defective Function of α-Ketoglutarate Dehydrogenase Exacerbates Mitochondrial ATP Deficits during Complex I Deficiency Open
The NDUFS4 knockout (KO) mouse phenotype resembles the human Complex I deficiency Leigh Syndrome. The irreversible succination of protein thiols by fumarate is increased in select regions of the NDUFS4 KO brain affected by neurodegeneratio…
View article: Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization Open
The fumarate ester dimethyl fumarate (DMF) has been introduced recently as a treatment for relapsing remitting multiple sclerosis (RRMS), a chronic inflammatory condition that results in neuronal demyelination and axonal loss. DMF is known…
View article: Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes
Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes Open
The current study demonstrates that early biochemical changes in mitochondrial metabolism have important implications for the development of adipocyte stress. Antioxid. Redox Signal. 27, 1281-1296.