Michael R. Deans
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Planar polarized organization of mouse hair cells is established and maintained by STK32A, GPR156 and EMX2 Open
Hair cells in the utricle and saccule form two groups with oppositely oriented stereociliary bundles that enable detection of broad ranges of motion. These groups are aligned along a common polarity axis established by core planar cell pol…
PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse organ of Corti Open
The organ of Corti is divided into functional compartments responsible for hearing or cochlear amplification. A medial compartment containing inner hair cells innervated by Type I spiral ganglion neurons and a lateral compartment containin…
PROX1 Controls Cellular Patterning, Innervation and Differentiation in the Mouse Organ of Corti Open
The organ of Corti is divided into functional compartments responsible for hearing or cochlear amplification. A medial compartment containing inner hair cells innervated by Type I spiral ganglion neurons and a lateral compartment containin…
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function Open
Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcription factor EMX2 is …
View article: Decoding the transcriptomic signatures of psychological trauma in human cortex and amygdala
Decoding the transcriptomic signatures of psychological trauma in human cortex and amygdala Open
Psychological trauma has profound effects on brain function and precipitates psychiatric disorders in vulnerable individuals, however, the molecular mechanisms linking trauma with psychiatric risk remain incompletely understood. Using RNA-…
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function Open
Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcription factor EMX2 is …
Dynamic neuro-immune regulation of psychiatric risk loci in human neurons Open
The prenatal environment influences neurodevelopment and subsequent clinical trajectories for psychiatric outcomes in childhood and adolescence. Yet it remains unclear if the impact of maternal and fetal immune activation varies with disti…
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function Open
Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcription factor EMX2 is …
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function Open
Summary/Abstract Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcriptio…
Reviewer #2 (Public Review): Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function Open
Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcription factor EMX2 is …
Reviewer #1 (Public Review): Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function Open
Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcription factor EMX2 is …
<i>Emx2</i> lineage tracing reveals antecedent patterns of planar polarity in the mouse inner ear Open
The planar polarized organization of hair cells in the vestibular maculae is unique because these sensory organs contain two groups of cells with oppositely oriented stereociliary bundles that meet at a line of polarity reversal (LPR). EMX…
View article: Large-scale annotated dataset for cochlear hair cell detection and classification
Large-scale annotated dataset for cochlear hair cell detection and classification Open
Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5–15 thousand terminally differentiated hair cells, an…
353 Eph/Ephrin Signaling Influences Innervation of Outer Hair Cells in Cochlea Open
OBJECTIVES/GOALS: 48,000,000 people in the U.S. have hearing loss, negatively impacting quality of life and work. Unveiling axon guidance for auditory type II spiral ganglia neurons (SGNs) will aid development of new therapies. I study the…
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function Open
Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcription factor EMX2 is …
View article: Large-scale annotated dataset for cochlear hair cell detection and classification
Large-scale annotated dataset for cochlear hair cell detection and classification Open
Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …
View article: Large-scale annotated dataset for cochlear hair cell detection and classification
Large-scale annotated dataset for cochlear hair cell detection and classification Open
Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …
View article: Common genetic variation impacts stress response in the brain
Common genetic variation impacts stress response in the brain Open
To explain why individuals exposed to identical stressors experience divergent clinical outcomes, we determine how molecular encoding of stress modifies genetic risk for brain disorders. Analysis of post-mortem brain (n=304) revealed 8557 …
View article: Large-scale annotated dataset for cochlear hair cell detection and classification
Large-scale annotated dataset for cochlear hair cell detection and classification Open
Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5 - 15 thousand terminally differentiated hair cells, …
View article: Large-scale annotated dataset for cochlear hair cell detection and classification
Large-scale annotated dataset for cochlear hair cell detection and classification Open
This is the dataset behind the Hair Cell Analysis Toolbox (HCAT)
<i>Emx2</i> Lineage Tracing Reveals Antecedent Patterns of Planar Polarity in the Mouse Inner Ear Open
The planar polarized organization of vestibular hair cells in the utricle and saccule is unique because these inner ear sensory organs contain two groups of hair cells with oppositely oriented stereociliary bundles that meet at a Line of P…
View article: Large-scale annotated dataset for cochlear hair cell detection and classification
Large-scale annotated dataset for cochlear hair cell detection and classification Open
Our sense of hearing is mediated by cochlear hair cells, localized within the sensory epithelium called the organ of Corti. There are two types of hair cells in the cochlea, which are organized in one row of inner hair cells and three rows…
Getting connected: Pathfinding and synaptogenesis in development, evolution, and disease, Part 2 Open
Continuing with our special issue “Getting connected: pathfinding and synaptogenesis in development, evolution, and disease,” Part 2 contains a collection of works following the broader theme of neural development. Two reviews included in …
View article: Large-scale annotated dataset for cochlear hair cell detection and classification
Large-scale annotated dataset for cochlear hair cell detection and classification Open
This is the dataset behind the Hair Cell Analysis Toolbox (HCAT)
The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear Open
The vestibular maculae of the inner ear contain sensory receptor hair cells that detect linear acceleration and contribute to equilibrioception to coordinate posture and ambulatory movements. These hair cells are divided between two groups…
Author response: The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The ves…
486 Molecular Mechanisms of Type II Spiral Ganglion Neuron Development Open
OBJECTIVES/GOALS: 30,000,000 people in the U.S. have hearing loss, negatively impacting quality of life and work. Understanding auditory axon guidance for spiral ganglia neurons (SGNs) will aid development of new therapies. I study role of…
Getting connected: Pathfinding and synaptogenesis in neural development, evolution, and disease Open
This special issue on neurobiology has an emphasis on molecular mechanisms of connectivity from axon-dendrite patterning to synapse form and function. A defining feature of the nervous system is the ability to form highly complex and speci…