Michael Donovan
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View article: Advances in Targeted Therapy for Non-Small-Cell Lung Cancer: Current Progress and Future Directions
Advances in Targeted Therapy for Non-Small-Cell Lung Cancer: Current Progress and Future Directions Open
The advent of targeted therapies has significantly transformed the management of non-small-cell lung cancer (NSCLC), improving survival across all disease stages. Discoveries of both common and rare oncogenic drivers are advancing rapidly,…
View article: A-063 Assessing the risk of measurement variability of model inputs on the accuracy and precision of kidneyintelX.dkd, a machine learning prognostic test for progression in Diabetic Kidney Disease
A-063 Assessing the risk of measurement variability of model inputs on the accuracy and precision of kidneyintelX.dkd, a machine learning prognostic test for progression in Diabetic Kidney Disease Open
Background Diabetic Kidney Disease (DKD) is a severe complication of diabetes that leads to kidney failure in about 5-15% of cases. The kidneyIntelX.dkd is an FDA approved prognostic blood test for assessing the risk of DKD progression, en…
View article: External validation of precisebreast, a digital prognostic test for predicting breast cancer recurrence, in an early-stage cohort from the Netherlands
External validation of precisebreast, a digital prognostic test for predicting breast cancer recurrence, in an early-stage cohort from the Netherlands Open
Background Current clinical guidelines recommend gene expression profiling to guide treatment in early-stage breast cancer. PreciseBreast (PDxBR) is a digital prognostic tool that integrates artificial intelligence (AI)-derived features fr…
View article: PreciseBreast is prognostic for breast cancer recurrence in a 21-gene assay managed cohort
PreciseBreast is prognostic for breast cancer recurrence in a 21-gene assay managed cohort Open
PreciseBreast (PDxBR) is an AI-based digital test that provides individualized risk prediction for invasive breast carcinoma (IBC) independent of a gene expression test and yields important prognostic information that may well guide decisi…
View article: A Diagnostic Mimic of Lung Cancer: Nodular Pulmonary Amyloidosis Presenting With Cystic Changes
A Diagnostic Mimic of Lung Cancer: Nodular Pulmonary Amyloidosis Presenting With Cystic Changes Open
Pulmonary amyloidosis is an uncommon but clinically significant disorder characterised by extracellular deposition of misfolded amyloid fibrils in lung tissue, either as part of systemic disease or as a localised entity. We present a case …
View article: Analytical validation of the LungLB test: a 4-color fluorescence in-situ hybridization assay for the evaluation of indeterminate pulmonary nodules
Analytical validation of the LungLB test: a 4-color fluorescence in-situ hybridization assay for the evaluation of indeterminate pulmonary nodules Open
Background Evaluation of indeterminate pulmonary nodules (IPNs) often creates a diagnostic conundrum which may delay the early detection of lung cancer. Rare circulating genetically abnormal cells (CGAC) have previously demonstrated utilit…
View article: U.S. payer budget impact of using an AI-augmented cancer risk discrimination digital histopathology platform to identify high-risk of recurrence in women with early-stage invasive breast cancer
U.S. payer budget impact of using an AI-augmented cancer risk discrimination digital histopathology platform to identify high-risk of recurrence in women with early-stage invasive breast cancer Open
Sensitivity analyses demonstrated robust overall savings to changes in all variables in the model. The use of PDxBr to assess breast cancer recurrence risk has the potential to fill gaps in care and reduce costs when gene expression signat…
View article: A Real-World Precision Medicine Program Including the KidneyIntelX Test Effectively Changes Management Decisions and Outcomes for Patients With Early-Stage Diabetic Kidney Disease
A Real-World Precision Medicine Program Including the KidneyIntelX Test Effectively Changes Management Decisions and Outcomes for Patients With Early-Stage Diabetic Kidney Disease Open
Introduction/Objective: The KidneyIntelX is a multiplex, bioprognostic, immunoassay consisting of 3 plasma biomarkers and clinical variables that uses machine learning to predict a patient’s risk for a progressive decline in kidney functio…
View article: Prospective observational study to validate a next-generation sequencing blood RNA signature to predict early kidney transplant rejection
Prospective observational study to validate a next-generation sequencing blood RNA signature to predict early kidney transplant rejection Open
The objective of this study was to validate the performance of Tutivia, a peripheral blood gene expression signature, in predicting early acute rejection (AR) post-kidney transplant. Recipients of living or deceased donor kidney transplant…
View article: Derivation and independent validation of <scp>kidneyintelX</scp> .dkd: A prognostic test for the assessment of diabetic kidney disease progression
Derivation and independent validation of <span>kidneyintelX</span> .dkd: A prognostic test for the assessment of diabetic kidney disease progression Open
Aims To develop and validate an updated version of KidneyIntelX (kidneyintelX.dkd) to stratify patients for risk of progression of diabetic kidney disease (DKD) stages 1 to 3, to simplify the test for clinical adoption and support an appli…
View article: The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer
The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer Open
Kinase inhibitors against Cyclin Dependent Kinase 4 and 6 (CDK4/6i) are promising cancer therapeutic drugs. However, their effects are limited by primary or acquired resistance in virtually all tumor types. Here, we demonstrate that Leucin…
View article: The presence of circulating genetically abnormal cells in blood predicts risk of lung cancer in individuals with indeterminate pulmonary nodules
The presence of circulating genetically abnormal cells in blood predicts risk of lung cancer in individuals with indeterminate pulmonary nodules Open
Purpose Computed tomography is the standard method by which pulmonary nodules are detected. Greater than 40% of pulmonary biopsies are not lung cancer and therefore not necessary, suggesting that improved diagnostic tools are needed. The L…
View article: ExoDx prostate test as a predictor of outcomes of high-grade prostate cancer – an interim analysis
ExoDx prostate test as a predictor of outcomes of high-grade prostate cancer – an interim analysis Open
Background Patient outcomes were assessed based on a pre-biopsy ExoDx Prostate (EPI) score at 2.5 years of the 5-year follow-up of ongoing prostate biopsy Decision Impact Trial of the ExoDx Prostate (IntelliScore). Methods Prospective, bli…
View article: Supplementary Figure Legends from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer
Supplementary Figure Legends from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer Open
PDF - 35K, Legends for Supplementary Figures 1 and 2.
View article: Supplementary Data 3 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
Supplementary Data 3 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade Open
Differentially expressed genes in rat prostates exposed to WTC dusts
View article: Supplementary Figure 1 from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer
Supplementary Figure 1 from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer Open
PDF - 265K, Biochemical-relapse analysis according to gene expression levels of markers differentially expressed in treated vs non-treated patients.
View article: Supplementary Table 1 from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer
Supplementary Table 1 from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer Open
PDF - 72K, Genes expression values by qRT-PCR in treated patients vs non-treated patients; TLDA: TaqMan Low Density Arrays; FDR: False Discovery Rate.
View article: Supplementary Figure Legends from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer
Supplementary Figure Legends from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer Open
PDF - 35K, Legends for Supplementary Figures 1 and 2.
View article: Supplementary Data 1 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
Supplementary Data 1 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade Open
Difference in gene expression between archived WTC and non WTC cases
View article: Supplementary Figures from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
Supplementary Figures from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade Open
Supplementary Figures 1-3
View article: Supplementary Table 1 from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer
Supplementary Table 1 from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer Open
PDF - 72K, Genes expression values by qRT-PCR in treated patients vs non-treated patients; TLDA: TaqMan Low Density Arrays; FDR: False Discovery Rate.
View article: Supplementary Data 2 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
Supplementary Data 2 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade Open
List of genes used in cell type enrichment analysis
View article: Supplementary Data 3 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
Supplementary Data 3 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade Open
Differentially expressed genes in rat prostates exposed to WTC dusts
View article: Supplementary Data 1 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
Supplementary Data 1 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade Open
Difference in gene expression between archived WTC and non WTC cases
View article: Data from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer
Data from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer Open
Molecular characterization of radical prostatectomy specimens after systemic therapy may identify a gene expression profile for resistance to therapy. This study assessed tumor cells from patients with prostate cancer participating in a ph…
View article: Supplementary Figures from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
Supplementary Figures from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade Open
Supplementary Figures 1-3
View article: Supplementary Figure 2 from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer
Supplementary Figure 2 from Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer Open
PDF - 475K, Radiological-progression analysis according to gene expression levels of markers differentially expressed in treated vs non-treated patients.