Michael P. Doyle
YOU?
Author Swipe
View article: 1,2,3-Triazine 1-Oxides Are a Productive Platform for Synthetic Methodologies
1,2,3-Triazine 1-Oxides Are a Productive Platform for Synthetic Methodologies Open
This graphical review provides a concise overview of the synthesis and uses of 4-carboxylato-1,2,3-triazine 1-oxides in diverse syntheses, especially of heterocyclic compounds. Prepared in high yields from reactions between vinyldiazoaceta…
View article: Design, Synthesis, In Vitro and In Silico Biological Evaluation of New Pyridine-2,5-Dicarboxylates Esters Bearing Natural Source Fragments as Anti-Trypanosomatid Agents
Design, Synthesis, In Vitro and In Silico Biological Evaluation of New Pyridine-2,5-Dicarboxylates Esters Bearing Natural Source Fragments as Anti-Trypanosomatid Agents Open
Background: Chagas disease and leishmaniasis remain public health concerns. Despite the existence of approved medications for the treatment of these diseases, most patients discontinue treatment due to long drug regimens and/or the severe …
View article: Antiparasitic Effect of Polyphenols and Terpenes from Natural Products Against Trypanosoma cruzi and Leishmania mexicana
Antiparasitic Effect of Polyphenols and Terpenes from Natural Products Against Trypanosoma cruzi and Leishmania mexicana Open
Background: Worldwide, the number of cases of parasitic diseases has been increasing; however, available treatments have variable adverse effects and low efficacy, mainly in Neglected Tropical Diseases such as Chagas disease and Leishmania…
View article: Colonization and Its Legacy: The Correlates of Indigenous Arrest
Colonization and Its Legacy: The Correlates of Indigenous Arrest Open
The Indigenous peoples of the United States, Canada, Australia and New Zealand are all over-represented in their prison systems. Yet despite a shared history of colonization and dispossession, most Indigenous peoples have little if any con…
View article: Photolytic Access to Oxaspirodecanes and Chromenes from Vinyldiazo Ester Cycloaddition with p-Quinones. A Vinylcarbene is not Involved
Photolytic Access to Oxaspirodecanes and Chromenes from Vinyldiazo Ester Cycloaddition with p-Quinones. A Vinylcarbene is not Involved Open
Synthetic methods that provide access to skeletally diverse heterocyclic motifs are poised to accelerate drug discovery and streamline synthesis of advanced intermediates and materials. However, the development of such synthetic methods ne…
View article: Assessing the potential role of deer in the dissemination of Mycobacterium bovis infection to cattle in Northern Ireland
Assessing the potential role of deer in the dissemination of Mycobacterium bovis infection to cattle in Northern Ireland Open
Mycobacterium bovis, the causative agent of animal tuberculosis, exhibits a broad host range - infecting, inducing pathology and transmitting from both bovine and wildlife hosts. Considerable effort has been extended to understanding the r…
View article: New era towards autonomous additive manufacturing: a review of recent trends and future perspectives
New era towards autonomous additive manufacturing: a review of recent trends and future perspectives Open
The additive manufacturing (AM) landscape has significantly transformed in alignment with Industry 4.0 principles, primarily driven by the integration of artificial intelligence (AI) and digital twins (DT). However, current intelligent AM …
View article: Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38
Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38 Open
View article: Photo-cycloaddition reactions of vinyldiazo compounds
Photo-cycloaddition reactions of vinyldiazo compounds Open
View article: Crimean-Congo Hemorrhagic Fever Survivors Elicit Protective Non-Neutralizing Antibodies that Target 11 Overlapping Regions on Viral Glycoprotein GP38
Crimean-Congo Hemorrhagic Fever Survivors Elicit Protective Non-Neutralizing Antibodies that Target 11 Overlapping Regions on Viral Glycoprotein GP38 Open
SUMMARY Crimean-Congo hemorrhagic fever virus can cause lethal disease in humans yet there are no approved medical countermeasures. Viral glycoprotein GP38, unique to Nairoviridae , is a target of protective antibodies, but extensive mappi…
View article: Whole-Genome sequencing in routine Mycobacterium bovis epidemiology – scoping the potential
Whole-Genome sequencing in routine Mycobacterium bovis epidemiology – scoping the potential Open
Mycobacterium bovis the main agent of bovine tuberculosis (bTB), presents as a series of spatially-localised micro-epidemics across landscapes. Classical molecular typing methods applied to these micro-epidemics, based on genotyping a few …
View article: Denitrogenative dismantling of heteroaromatics by nucleophilic substitution reactions with diazomethyl compounds
Denitrogenative dismantling of heteroaromatics by nucleophilic substitution reactions with diazomethyl compounds Open
We report divergent reactions of 1,2,3-triazines and 1,2,3-triazine 1-oxides with diazomethyl compounds, the former yielding diazovinylketoesters, and the latter giving rise to pyrazole derivatives through extrusion of ethyl cyanocarboxyla…
View article: Photoinduced [4 + 2]-cycloaddition reactions of vinyldiazo compounds for the construction of heterocyclic and bicyclic rings
Photoinduced [4 + 2]-cycloaddition reactions of vinyldiazo compounds for the construction of heterocyclic and bicyclic rings Open
Under blue light vinyldiazoacetate reagents selectively form unstable cyclopropenes that undergo intermolecular cycloaddition reactions at a faster rate than their competitive ene dimerization.
View article: The “cesium effect” magnified: exceptional chemoselectivity in cesium ion mediated nucleophilic reactions
The “cesium effect” magnified: exceptional chemoselectivity in cesium ion mediated nucleophilic reactions Open
Synthetically challenging pyridones and pyridylpyridones can now be readily accessed from simple precursors in a chemodivergent oxadiaza excision cross-coupling enabled by an unprecedented conformational accommodation-driven cesium effect.
View article: CCDC 2125940: Experimental Crystal Structure Determination
CCDC 2125940: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2125942: Experimental Crystal Structure Determination
CCDC 2125942: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2205896: Experimental Crystal Structure Determination
CCDC 2205896: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2088139: Experimental Crystal Structure Determination
CCDC 2088139: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Site Reversal in Nucleophilic Addition to 1,2,3-Triazine 1-Oxides
Site Reversal in Nucleophilic Addition to 1,2,3-Triazine 1-Oxides Open
One of the most important reactions of 1,2,3-triazines with a dienophile is inverse electron demand Diels-Alder (IEDDA) cycloaddition, which occurs through nucleophilic addition to the triazine followed by N2 loss and cyclizatio…
View article: CCDC 2093833: Experimental Crystal Structure Determination
CCDC 2093833: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2093834: Experimental Crystal Structure Determination
CCDC 2093834: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2247647: Experimental Crystal Structure Determination
CCDC 2247647: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1976900: Experimental Crystal Structure Determination
CCDC 1976900: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2247648: Experimental Crystal Structure Determination
CCDC 2247648: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2163520: Experimental Crystal Structure Determination
CCDC 2163520: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Data from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
Data from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Open
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic can…
View article: Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Open
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Fig…
View article: Data from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
Data from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Open
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic can…
View article: Police custody in Australia: A call for transparency and accountability
Police custody in Australia: A call for transparency and accountability Open
View article: Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
Supplementary Figures 1 - 5, Tables 1 - 2 from Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Open
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Fig…