Michael E. Douglas
YOU?
Author Swipe
View article: Machine learning for refining interpretation of magnetic resonance imaging scans in the management of multiple sclerosis: a narrative review
Machine learning for refining interpretation of magnetic resonance imaging scans in the management of multiple sclerosis: a narrative review Open
Multiple sclerosis (MS) is an autoimmune disease of the brain and spinal cord with both inflammatory and neurodegenerative features. Although advances in imaging techniques, particularly magnetic resonance imaging (MRI), have improved the …
View article: GeoGenIE: a deep learning approach to predict geographic provenance of biodiversity samples from genomic SNPs
GeoGenIE: a deep learning approach to predict geographic provenance of biodiversity samples from genomic SNPs Open
Motivation Determining geographic origin of samples is a common objective in wildlife management, forensics, and conservation. Current methods often assume evolutionary models or require extensive reference datasets, which are costly and d…
View article: autoStreamTree: Genomic variant data fitted togeospatial networks
autoStreamTree: Genomic variant data fitted togeospatial networks Open
Landscape genetics is a statistical framework that parses genetic variation within the context of spatial covariates, but current analytical methods typically fail to accommodate the unique topologies and autocorrelations inherent to netwo…
View article: The generation and validation of two NKX2-5 fluorescent reporter human embryonic stem cell lines: UMANe002-A-1 and UMANe002-A-2
The generation and validation of two NKX2-5 fluorescent reporter human embryonic stem cell lines: UMANe002-A-1 and UMANe002-A-2 Open
The transcription factor NKX2-5 is a highly conserved master regulator of heart development which is widely expressed in cardiac progenitors and cardiomyocytes. Fluorescent reporters of NKX2-5 that minimally perturb normal protein expressi…
View article: The Himalayan uplift and evolution of aquatic biodiversity across Asia: Snowtrout (Cyprininae: Schizothorax) as a test case
The Himalayan uplift and evolution of aquatic biodiversity across Asia: Snowtrout (Cyprininae: Schizothorax) as a test case Open
Global biodiversity hotspots are often remote, tectonically active areas undergoing climatic fluctuations, such as the Himalaya Mountains and neighboring Qinghai-Tibetan Plateau (QTP). They provide biogeographic templates upon which endemi…
View article: autoStreamTree: Genomic variant data fitted to geospatial networks
autoStreamTree: Genomic variant data fitted to geospatial networks Open
Summary Landscape genetics is a statistical framework that parses genetic variation within the context of spatial covariates, but current analytical methods typically fail to accommodate the unique topologies and autocorrelations inherent …
View article: A community genomics approach to natural hybridization
A community genomics approach to natural hybridization Open
Hybridization is a complicated, oft-misunderstood process. Once deemed unnatural and uncommon, hybridization is now recognized as ubiquitous among species. But hybridization rates within and among communities are poorly understood despite …
View article: AdmixPipe v3: facilitating population structure delimitation from SNP data
AdmixPipe v3: facilitating population structure delimitation from SNP data Open
Summary Quantifying genetic clusters (=populations) from genotypic data is a fundamental, but non-trivial task for population geneticists that is compounded by: hierarchical population structure, diverse analytical methods, and complex sof…
View article: Riverscape community genomics: A comparative analytical approach to identify common drivers of spatial structure
Riverscape community genomics: A comparative analytical approach to identify common drivers of spatial structure Open
Genetic differentiation among local groups of individuals, i.e., genetic β-diversity, is a key component of population persistence related to connectivity and isolation. However, most genetic investigations of natural populations focus on …
View article: A community genomics approach to natural hybridization
A community genomics approach to natural hybridization Open
Hybridization is a complicated, oft-misunderstood process. Once deemed unnatural and uncommon, hybridization is now recognized as ubiquitous among species. But hybridization rates within and among communities are poorly understood despite …
View article: Trait-based predictors of genomic diversity within freshwater fish communities of the Ozarks
Trait-based predictors of genomic diversity within freshwater fish communities of the Ozarks Open
Phenotypic traits modulate the fate of species interactions with one another and the environment; thus, traits directly shape the past, present, and future evolutionary trajectories of populations. As such, distinct species-specific respon…
View article: Relictual Hybridization and Biogeography of Massasauga Rattlesnakes (<i>Sistrurus</i>spp.)
Relictual Hybridization and Biogeography of Massasauga Rattlesnakes (<i>Sistrurus</i>spp.) Open
Climate change inevitably leaves behind a genetic footprint within phylogeographic legacies of affected species, as individuals are driven to either disperse to track suitable conditions or adapt in situ . One potential consequence is the …
View article: Limited gene flow and pronounced population genetic structure of Eastern Massasauga (Sistrurus catenatus) in a Midwestern prairie remnant
Limited gene flow and pronounced population genetic structure of Eastern Massasauga (Sistrurus catenatus) in a Midwestern prairie remnant Open
As anthropogenic changes continue to ecologically stress wildlife, obtaining measures of gene flow and genetic diversity are crucial for evaluating population trends and considering management and conservation strategies for small, imperil…
View article: Coproduction mechanisms to weave Indigenous knowledge, artificial intelligence, and technical data to enable Indigenous-led adaptive decision making: lessons from Australia’s joint managed Kakadu National Park
Coproduction mechanisms to weave Indigenous knowledge, artificial intelligence, and technical data to enable Indigenous-led adaptive decision making: lessons from Australia’s joint managed Kakadu National Park Open
Most of the planet’s vital ecosystems are managed on lands owned by Indigenous peoples. Indigenous people face many challenges in managing these lands, including rapidly growing threats causing species extinctions and ecosystem losses. In …
View article: Population connectivity in voles (Microtus sp.) as a gauge for tall grass prairie restoration in midwestern North America
Population connectivity in voles (Microtus sp.) as a gauge for tall grass prairie restoration in midwestern North America Open
Ecological restoration can promote biodiversity conservation in anthropogenically fragmented habitats, but effectiveness of these management efforts need to be statistically validated to determine ’success.’ One such approach is to gauge t…
View article: Parallel introgression, not recurrent emergence, explains apparent elevational ecotypes of polyploid Himalayan snowtrout
Parallel introgression, not recurrent emergence, explains apparent elevational ecotypes of polyploid Himalayan snowtrout Open
The recurrence of similar evolutionary patterns within different habitats often reflects parallel selective pressures acting upon either standing or independently occurring genetic variation to produce a convergence of phenotypes. This int…
View article: Female persistence during toxicant treatment predicts survival probability of offspring in invasive brown treesnakes (Boiga irregularis)
Female persistence during toxicant treatment predicts survival probability of offspring in invasive brown treesnakes (Boiga irregularis) Open
Assessing the long-term efficacy of control methods is a critical component of invasive species management. For example, if traits related to control have significant heritability or are influenced by maternal effects, control methods may …
View article: Taxonomic Uncertainty and the Anomaly Zone: Phylogenomics Disentangle a Rapid Radiation to Resolve Contentious Species ( <i>Gila robusta</i> Complex) in the Colorado River
Taxonomic Uncertainty and the Anomaly Zone: Phylogenomics Disentangle a Rapid Radiation to Resolve Contentious Species ( <i>Gila robusta</i> Complex) in the Colorado River Open
Species are indisputable units for biodiversity conservation, yet their delimitation is fraught with both conceptual and methodological difficulties. A classic example is the taxonomic controversy surrounding the Gila robusta complex in th…
View article: Born to move: a review on the impact of physical exercise on brain health and the evidence from human controlled trials.
Born to move: a review on the impact of physical exercise on brain health and the evidence from human controlled trials. Open
Even though this review found that physical exercise improves brain plasticity in humans, particularly through changes in brain-derived neurotrophic factor (BDNF), functional connectivity, basal ganglia and the hippocampus, many unanswered…
View article: Parallel introgression, not recurrent emergence, explains apparent elevational ecotypes of polyploid Himalayan snowtrout
Parallel introgression, not recurrent emergence, explains apparent elevational ecotypes of polyploid Himalayan snowtrout Open
The recurrence of similar evolutionary patterns within different habitats often reflects parallel selective pressures acting upon either standing or independently occurring genetic variation to produce a convergence of phenotypes. This int…
View article: Are populations of economically important bonefish and queen conch 'open' or 'closed' in the northern caribbean basin?
Are populations of economically important bonefish and queen conch 'open' or 'closed' in the northern caribbean basin? Open
Demographics of co‐occurring species can often be diagnosed through population genomic analyses of single nucleotide polymorphisms (SNPs). These data can define population structure, gene flow, and candidate regions in the genome that pote…
View article: Taxonomic hypotheses and the biogeography of speciation in the Tiger Whiptail complex (Aspidoscelis tigris: Squamata, Teiidae)
Taxonomic hypotheses and the biogeography of speciation in the Tiger Whiptail complex (Aspidoscelis tigris: Squamata, Teiidae) Open
Biodiversity in southwestern North America has a complex biogeographic history involving tectonism interspersed with climatic fluctuations. This yields a contemporary pattern replete with historic idiosyncrasies often difficult to interpre…
View article: Population connectivity in voles (Microtus sp.) as a gauge for tall grass prairie restoration in midwestern North America
Population connectivity in voles (Microtus sp.) as a gauge for tall grass prairie restoration in midwestern North America Open
Ecological restoration can promote biodiversity conservation in anthropogenically fragmented habitats, but effectiveness of these management efforts need to be statistically validated to determine ’success.’ One such approach is to gauge t…
View article: Metapopulation connectivity in Voles (<i>Microtus</i>sp.) as a gauge for tallgrass prairie restoration in midwestern North America
Metapopulation connectivity in Voles (<i>Microtus</i>sp.) as a gauge for tallgrass prairie restoration in midwestern North America Open
Applying quantifiable metrics to validate the success of restoration efforts is crucial for ongoing management programs in anthropogenically fragmented habitats. Estimates of dispersal can provide such baseline data because they measure no…
View article: The Himalayan Uplift and the Evolution of Aquatic Biodiversity Across Asia: Snowtrout (Cyprininae: <i>Schizothora</i>x) as a Test Case
The Himalayan Uplift and the Evolution of Aquatic Biodiversity Across Asia: Snowtrout (Cyprininae: <i>Schizothora</i>x) as a Test Case Open
The Himalayan uplift, a tectonic event of global importance, seemingly disseminated aquatic biodiversity broadly across Asia. But surprisingly, this hypothesis has yet to be tested. We do so herein by sequencing 1,140 base-pair of mtDNA cy…