Ernest M. Graham
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View article: Preserved Limbic White Matter Predicts Favorable 2‐Year Outcomes in Neonatal Hypoxic‐Ischemic Encephalopathy
Preserved Limbic White Matter Predicts Favorable 2‐Year Outcomes in Neonatal Hypoxic‐Ischemic Encephalopathy Open
Objective Accurate prediction of both favorable and unfavorable long‐term neurodevelopmental outcomes of neonatal hypoxic‐ischemic encephalopathy (HIE) is essential for clinical care, yet the brain structures underlying a favorable prognos…
View article: Marked Variation in Paediatric Problematic Severe Asthma Services Across Australia and New Zealand
Marked Variation in Paediatric Problematic Severe Asthma Services Across Australia and New Zealand Open
Aims Asthma affects > 10% of children in Australia and New Zealand (NZ), with up to 5% of those having severe disease, presenting a management challenge. We aimed to survey tertiary paediatric respiratory services across Australia and NZ u…
View article: Automatic photoacoustic monitoring of perinatal brain hypoxia with superior sagittal sinus detection
Automatic photoacoustic monitoring of perinatal brain hypoxia with superior sagittal sinus detection Open
The proposed automatic monitoring solution demonstrated a hypoxia detection capability comparable to the human expert manual annotation on the same task. We concluded with high feasibility for a noninvasive PA-based continuous moni…
View article: Seizures May Worsen Outcomes of Neonatal Hypoxic-Ischemic Encephalopathy: A Longitudinal Serum Biomarkers Study
Seizures May Worsen Outcomes of Neonatal Hypoxic-Ischemic Encephalopathy: A Longitudinal Serum Biomarkers Study Open
Tau and NF-L levels are higher in those neonates developing Sz. Although relationships with worse brain injury may be driven by the HIE severity itself, modeling shows Sz as the most important feature, providing support to the notion that …
View article: Seizures may worsen outcomes of neonatal hypoxic ischemic encephalopathy: a longitudinal serum biomarkers study
Seizures may worsen outcomes of neonatal hypoxic ischemic encephalopathy: a longitudinal serum biomarkers study Open
Introduction Screening and treatment of seizures (Sz) in neonates suffering from hypoxic-ischemic encephalopathy (HIE) is routine. Understanding if Sz worsen brain injury and outcomes would optimize treatment decisions, recognizing risks a…
View article: Evaluating Injury Severity in Neonatal Encephalopathy Using Automated Quantitative Electroencephalography Analysis: A Pilot Study
Evaluating Injury Severity in Neonatal Encephalopathy Using Automated Quantitative Electroencephalography Analysis: A Pilot Study Open
Quantitative analysis of electroencephalography (qEEG) is a potential source of biomarkers for neonatal encephalopathy (NE). However, prior studies using qEEG in NE were limited in their generalizability due to individualized techniques fo…
View article: Quantification of Diffusion Magnetic Resonance Imaging for Prognostic Prediction of Neonatal Hypoxic-Ischemic Encephalopathy
Quantification of Diffusion Magnetic Resonance Imaging for Prognostic Prediction of Neonatal Hypoxic-Ischemic Encephalopathy Open
Neonatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of acquired neonatal brain injury with the risk of developing serious neurological sequelae and death. An accurate and robust prediction of short- and long-term outcomes m…
View article: Development of a composite diffusion tensor imaging score correlating with short-term neurological status in neonatal hypoxic–ischemic encephalopathy
Development of a composite diffusion tensor imaging score correlating with short-term neurological status in neonatal hypoxic–ischemic encephalopathy Open
Hypoxic–ischemic encephalopathy (HIE) is the most common cause of neonatal acquired brain injury. Although conventional MRI may predict neurodevelopmental outcomes, accurate prognostication remains difficult. As diffusion tensor imaging (D…
View article: Assisted reproductive technology: Short‐ and long‐term outcomes
Assisted reproductive technology: Short‐ and long‐term outcomes Open
Assisted reproductive technology (ART) includes fertility treatment in which either eggs or embryos are handled outside a female's body to promote successful pregnancies and healthy offspring. Current ART procedures encompass in vitro fert…
View article: Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets in vivo
Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets in vivo Open
Objective: Perinatal ischemic stroke is estimated to occur in 1/2300–1/5000 live births, but early differential diagnosis from global hypoxia-ischemia is often difficult. In this study, we tested the ability of a hand-held transcranial pho…
View article: Therapeutic Hypothermia Modulates the Relationships Between Indicators of Severity of Neonatal Hypoxic Ischemic Encephalopathy and Serum Biomarkers
Therapeutic Hypothermia Modulates the Relationships Between Indicators of Severity of Neonatal Hypoxic Ischemic Encephalopathy and Serum Biomarkers Open
Objective: To determine the changes due to therapeutic hypothermia (TH) exposure in the strength of association between traditional clinical and biochemical indicators of severity of neonatal hypoxic-ischemic encephalopathy (HIE) and serum…
View article: Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets <i>in vivo</i>
Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets <i>in vivo</i> Open
Perinatal ischemic stroke is estimated to occur in 1/2300–1/5000 live births, but early differential diagnosis from global hypoxia-ischemia is often difficult. In this study, we tested the ability of a hand-held transcranial photoacoustic …
View article: Tiny Bodies, Big Needs: Prospective Biobanking of Neonatal Clinical Remnant Samples
Tiny Bodies, Big Needs: Prospective Biobanking of Neonatal Clinical Remnant Samples Open
Repurposing biological samples collected for required diagnostic purposes into suitable biobanking projects is a particularly useful method for enabling research in vulnerable populations. This approach is especially appropriate for the ne…
View article: Light-emitting diode-based transcranial photoacoustic measurement of sagittal sinus oxyhemoglobin saturation in hypoxic neonatal piglets
Light-emitting diode-based transcranial photoacoustic measurement of sagittal sinus oxyhemoglobin saturation in hypoxic neonatal piglets Open
We present a light-emitting diode (LED)-based transcranial photoacoustic measurement (LED-trPA) of oxyhemoglobin (HbO 2 ) saturation at superior sagittal sinus (SSS) in hypoxic neonatal piglets. The optimal LED imaging wavelengths and fram…
View article: Placental malperfusion in response to intrauterine inflammation and its connection to fetal sequelae
Placental malperfusion in response to intrauterine inflammation and its connection to fetal sequelae Open
Exposure to intrauterine inflammation (IUI) is associated with short- and long-term adverse perinatal outcomes. However, little data exist on utilizing placenta to prognosticate fetal injury in this scenario. Our study aimed to utilize ima…
View article: 17α-Hydroxyprogesterone Caproate and the Risk of Glucose Intolerance in Pregnancy
17α-Hydroxyprogesterone Caproate and the Risk of Glucose Intolerance in Pregnancy Open
OBJECTIVE: To evaluate whether 17α-hydroxyprogesterone caproate use in preventing preterm birth increases the risk of gestational diabetes mellitus (GDM). DATA SOURCES: Electronic databases (MEDLINE, Scopus, ClinicalTrials.gov, PROSPERO, E…
View article: Obstetric management, tests, and technologies that impact childhood development
Obstetric management, tests, and technologies that impact childhood development Open
Childhood brain development begins before birth, and obstetric management, tests, and technologies designed to diagnose and treat fetal conditions can have an impact on development. Preconception counseling for maternal diabetes and hypert…
View article: Adjuvant 17-hydroxyprogesterone caproate in women withultrasound-indicated cerclage: a systematic review and meta-analysis
Adjuvant 17-hydroxyprogesterone caproate in women withultrasound-indicated cerclage: a systematic review and meta-analysis Open
Objective: To assess the additional benefits of 17-hydroxyprogesterone caproate (17-OHPC) therapy in preventing recurrent spontaneous preterm birth in women with an ultrasound-indicated cerclage.Methods: Electronic databases (Medline, Scop…