Michael Elgart
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View article: Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos
Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos Open
View article: Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations
Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations Open
View article: Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores
Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores Open
We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model ensemble, consisting o…
View article: Organ transformation by environmental disruption of protein integrity and epigenetic memory in Drosophila
Organ transformation by environmental disruption of protein integrity and epigenetic memory in Drosophila Open
Despite significant progress in understanding epigenetic reprogramming of cells, the mechanistic basis of “organ reprogramming” by (epi-)gene–environment interactions remained largely obscure. Here, we use the ether-induced haltere-to-wing…
View article: A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically determined protein-protein networks
A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically determined protein-protein networks Open
Genetic correlation refers to the correlation between genetic determinants of a pair of traits. When using individual-level data, it is typically estimated based on a bivariate model specification where the correlation between the two vari…
View article: Correlations between complex human phenotypes vary by genetic background, gender, and environment
Correlations between complex human phenotypes vary by genetic background, gender, and environment Open
We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental corre…
View article: Machine learning models for blood pressure phenotypes combining multiple polygenic risk scores
Machine learning models for blood pressure phenotypes combining multiple polygenic risk scores Open
We construct non-linear machine learning (ML) prediction models for systolic and diastolic blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk scores (PRSs). We developed a two-model ensemble, consisting o…
View article: Anaerobic pathogens associated with OSA may contribute to pathophysiology via amino-acid depletion
Anaerobic pathogens associated with OSA may contribute to pathophysiology via amino-acid depletion Open
Described in methods.
View article: A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically-determined protein-protein networks
A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically-determined protein-protein networks Open
Genetic correlation refers to the correlation between genetic determinants of a pair of traits. When using individual-level data, it is typically estimated based on a bivariate model specification where the correlation between the two vari…
View article: CoSMIC - A hybrid approach for large-scale, high-resolution microbial profiling of novel niches
CoSMIC - A hybrid approach for large-scale, high-resolution microbial profiling of novel niches Open
Standard microbial profiling based on 16S rRNA (16S) sequencing suffers from a lack of primer universality, primer biases and often yields low resolution. We introduce 'Comprehensive Small Ribosomal Subunit Mapping and Identification of Co…
View article: Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos
Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos Open
Described in Acknowledgments.
View article: Correlations between complex human phenotypes vary by genetic background, gender, and environment
Correlations between complex human phenotypes vary by genetic background, gender, and environment Open
We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental corre…
View article: Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS/SOL
Genetic determinants of cardiometabolic and pulmonary phenotypes and obstructive sleep apnoea in HCHS/SOL Open
View article: Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations
Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations Open
View article: 0034 Genetic Determinants of Cardiometabolic and Pulmonary Traits and Obstructive Sleep Apnea in the Hispanic Community Health Study/Study of Latinos
0034 Genetic Determinants of Cardiometabolic and Pulmonary Traits and Obstructive Sleep Apnea in the Hispanic Community Health Study/Study of Latinos Open
Introduction Obstructive sleep apnea (OSA) often co-occurs with other health outcomes. The respiratory event index (REI), often used to define OSA, is similarly correlated with several health phenotypes. Genetic data provide an opportunity…
View article: Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex
Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex Open
We developed novel closed-form estimators of genetic and environmental correlation coefficients. We applied them to estimate over 4,000 genetic and environmental correlations between multiple phenotypes in a diverse sample from the Trans-O…
View article: Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes
Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes Open
Polygenic risk scores (PRS) are commonly used to quantify the inherited susceptibility for a given trait. However, the standard PRS fail to account for non-linear and interaction effects between single nucleotide polymorphisms (SNPs). Mach…
View article: Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes
Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes Open
Gut microbiota have been shown to promote oogenesis and fecundity, but the mechanistic basis of remote influence on oogenesis remained unknown. Here, we report a systemic mechanism of influence mediated by bacterial-derived supply of mitoc…
View article: Machine and Deep Learning in Molecular and Genetic Aspects of Sleep Research
Machine and Deep Learning in Molecular and Genetic Aspects of Sleep Research Open
View article: Stimulating Nitrogen Biokinetics with the Addition of Hydrogen Peroxide to Secondary Effluent Biofiltration
Stimulating Nitrogen Biokinetics with the Addition of Hydrogen Peroxide to Secondary Effluent Biofiltration Open
Tertiary wastewater treatment could provide a reliable source of water for reuse. Amongst these types of wastewater treatment, deep-bed filtration of secondary effluents can effectively remove particles and organic matter; however, NH4+ an…
View article: Waddington Revisited: Organ transformation by environmental disruption of epigenetic memory
Waddington Revisited: Organ transformation by environmental disruption of epigenetic memory Open
Despite major progress in mechanistic understanding of epigenetic reprogramming of cells, the basis of ‘organ reprograming’ by (epi-)gene-environment interactions remained largely obscured. Here we use the ether-induced haltere-to-wing tra…
View article: Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling
Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling Open
SMURF enables the identification of near full-length 16S rRNA gene sequences in microbial communities, having resolution superior compared to current techniques. It may be applied to standard sample preparation protocols with very little m…
View article: Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling
Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling Open
Background Most of our knowledge about the remarkable microbial diversity on Earth comes from sequencing the 16S rRNA gene. The use of next-generation sequencing methods has increased sample number and sequencing depth, but the read length…
View article: Impact of gut microbiota on the fly’s germ line
Impact of gut microbiota on the fly’s germ line Open
Unlike vertically transmitted endosymbionts, which have broad effects on their host’s germ line, the extracellular gut microbiota is transmitted horizontally and is not known to influence the germ line. Here we provide evidence supporting …
View article: A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation
A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation Open
The hypothesis raises a critical, but thus far overlooked adaptation problem and explains how random variation can self-organize to confer a wide range of individual-specific adaptations beyond the existing outcomes of natural selection. I…