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View article: Correction to “A Structurally Diverse Compound Screening Library to Identify Substrates for Diamine, Polyamine, and Related Acetyltransferases”
Correction to “A Structurally Diverse Compound Screening Library to Identify Substrates for Diamine, Polyamine, and Related Acetyltransferases” Open
[This corrects the article DOI: 10.1021/acsomega.4c08743.].
View article: A Structurally Diverse Compound Screening Library to Identify Substrates for Diamine, Polyamine, and Related Acetyltransferases
A Structurally Diverse Compound Screening Library to Identify Substrates for Diamine, Polyamine, and Related Acetyltransferases Open
Spermidine/spermine N-acetyltransferases (SSATs) and other types of polyamine acetyltransferases (PAATs) acetylate diamines and/or polyamines. These enzymes are evolutionarily related and belong to the Gcn5-related N-acetyltransferase (GNA…
Corrigendum: Nα -acetyl-L-ornithine deacetylase from Escherichia coli and a ninhydrin-based assay to enable inhibitor identification Open
Graphical Abstract
Nα-acetyl-L-ornithine deacetylase from Escherichia coli and a ninhydrin-based assay to enable inhibitor identification Open
Bacteria are becoming increasingly resistant to antibiotics, therefore there is an urgent need for new classes of antibiotics to fight antibiotic resistance. Mammals do not express N ɑ -acetyl-L-ornithine deacetylase (ArgE), an enzyme that…
View article: Revealing reaction intermediates in one-carbon elongation ThDP/CoA dependent enzyme family
Revealing reaction intermediates in one-carbon elongation ThDP/CoA dependent enzyme family Open
2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, con…
View article: A Structural Systems Biology Approach to High-Risk CG23 Klebsiella pneumoniae
A Structural Systems Biology Approach to High-Risk CG23 Klebsiella pneumoniae Open
Klebsiella pneumoniae is a leading cause of antibiotic-resistant-associated deaths in the world. Here, we report the deposition of 14 structures of enzymes from both the core and accessory genomes of sequence type 23 (ST23) K1 hypervirulen…
View article: Data collection from crystals grown in microfluidic droplets
Data collection from crystals grown in microfluidic droplets Open
Protein crystals grown in microfluidic droplets have been shown to be an effective and robust platform for storage, transport and serial crystallography data collection with a minimal impact on diffraction quality. Single macromolecular mi…
View article: Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin
Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin Open
The Papain-like protease (PLpro) is a domain of a multi-functional, non-structural protein 3 of coronaviruses. PLpro cleaves viral polyproteins and posttranslational conjugates with poly-ubiquitin and protective ISG15, composed of two ubiq…
View article: Time-Resolved β-lactam Cleavage by L1 Metallo-β-Lactamase
Time-Resolved β-lactam Cleavage by L1 Metallo-β-Lactamase Open
Serial x-ray crystallography can uncover binding events, and subsequent chemical conversions occurring during enzymatic reaction. Here we reveal the structure, binding and cleavage of moxalactam antibiotic bound to L1 metallo-β-lactamase (…
View article: Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens
Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens Open
The question of how new enzyme activities evolve is of great biological interest and, in the context of antibiotic resistance, of great medical importance. Here, we have tested the hypothesis that new antibiotic resistance mechanisms may e…
View article: Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin
Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin Open
The Papain-like protease (PLpro) is a domain of a multi-functional, non-structural protein 3 of coronaviruses. PLpro cleaves viral polyproteins and posttranslational conjugates with poly-ubiquitin and protective ISG15, composed of two ubiq…
View article: Sensor Domain of Histidine Kinase VxrA of Vibrio cholerae: Hairpin-Swapped Dimer and Its Conformational Change
Sensor Domain of Histidine Kinase VxrA of Vibrio cholerae: Hairpin-Swapped Dimer and Its Conformational Change Open
V. cholerae has a dynamic life cycle, which requires rapid adaptation to changing external conditions. Two-component signal transduction (TCS) systems allow V. cholerae to sense and respond to these environmental changes.
View article: Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors Open
The number of new cases world-wide for the COVID-19 disease is increasing dramatically, while efforts to contain Severe Acute Respiratory Syndrome Coronavirus 2 is producing varied results in different countries. There are three key SARS-C…
View article: Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes Open
Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macro…
View article: Crystal structures of SARS-CoV-2 ADP-ribose phosphatase (ADRP): from the apo form to ligand complexes
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase (ADRP): from the apo form to ligand complexes Open
Among 15 nonstructural proteins (Nsps), the newly emerging SARS-CoV-2 encodes a large, multidomain Nsp3. One of its units is ADP-ribose phosphatase domain (ADRP, also known as macrodomain) which is believed to interfere with the host immun…
View article: The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine Open
SARS-CoV-2 is a member of the coronaviridae family and is the etiological agent of the respiratory Coronavirus Disease 2019. The virus has spread rapidly around the world resulting in over two million cases and nearly 150,000 deaths as of …
View article: Crystal structure of Nsp15 endoribonuclease <scp>NendoU</scp> from <scp>SARS‐CoV</scp> ‐2
Crystal structure of Nsp15 endoribonuclease <span>NendoU</span> from <span>SARS‐CoV</span> ‐2 Open
Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and…
View article: Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2
Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2 Open
Severe Acute Respiratory Syndrome Coronavirus 2 is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS-…
3D domain swapping in the TIM barrel of the α subunit of<i>Streptococcus pneumoniae</i>tryptophan synthase Open
Tryptophan synthase catalyzes the last two steps of tryptophan biosynthesis in plants, fungi and bacteria. It consists of two protein chains, designated α and β, encoded by trpA and trpB genes, that function as an αββα complex. Structural …
View article: Structural and biochemical analysis of the metallo‐β‐lactamase L1 from emerging pathogen <i>Stenotrophomonas maltophilia</i> revealed the subtle but distinct di‐metal scaffold for catalytic activity
Structural and biochemical analysis of the metallo‐β‐lactamase L1 from emerging pathogen <i>Stenotrophomonas maltophilia</i> revealed the subtle but distinct di‐metal scaffold for catalytic activity Open
Emergence of Enterobacteriaceae harboring metallo‐β‐lactamases (MBL) has raised global threats due to their broad antibiotic resistance profiles and the lack of effective inhibitors against them. We have been studied one of the emerging en…
View article: Conservation of the structure and function of bacterial tryptophan synthases
Conservation of the structure and function of bacterial tryptophan synthases Open
Tryptophan biosynthesis is one of the most characterized processes in bacteria, in which the enzymes from Salmonella typhimurium and Escherichia coli serve as model systems. Tryptophan synthase (TrpAB) catalyzes the final two steps of tryp…