Michael Engelbrecht Nielsen

Effective management of acne fulminans: Two case reports highlighting fluorescent light energy therapy Open

J.L. López‐Estebaranz, Matteo Bordingnon, Roberta Tardugno, Michael Engelbrecht Nielsen · 2024

Background Acne vulgaris stands as a prevailing skin condition among adolescents worldwide. Objectives The primary aim in addressing acne is to manage it effectively, preventing the occurrence of permanent scarring. Materials and Methods T…

LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade Open

Amber Hickman, Joost Koetsier, Trevin Kurtanich, Michael Engelbrecht Nielsen, Glenn Winn , et al. · 2022

The inability of CD8+ effector T cells (Teffs) to reach tumor cells is an important aspect of tumor resistance to cancer immunotherapy. The recruitment of these cells to the tumor microenvironment (TME) is regulated by integrins, a family …

Biophotonic Therapy with Fluorescent Light Energy Decreases Facial Erythema, Improves Signs and Symptoms of Rosacea, and Increases Patient Satisfaction: A Postmarket Study. Open

Martin Wade, Vanessa Charest, Bruno Ballardin, Deirdre Edge, Michael Engelbrecht Nielsen · 2021

Our results support FLE as an effective, noninvasive treatment modality for rosacea.

Fluorescent light energy combined with systemic isotretinoin: A 52‐week follow‐up evaluating efficacy and safety in treatment of moderate‐severe acne Open

Antonio Russo, Maiken Mellergaard, Giovanni Pellacani, Steven Paul Nisticò, Michael Engelbrecht Nielsen · 2021

Fluorescent light energy therapy combined with low‐dose isotretinoin or tetracycline show remarkable clinical effect on 12 cases of moderate‐to‐severe acne. Treatment was considered safe, well‐tolerated, and highly efficacious.

Fluorescent light energy modulates healing in skin grafted mouse model Open

Jie Ding, Maiken Mellergaard, Zhensen Zhu, Peter Kwan, Deirdre Edge , et al. · 2021

Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. …

Evaluation of Fluorescent Light Energy for the Treatment of Acute Second-degree Burns Open

Maiken Mellergaard, Stéphane Fauverghe, Carlotta Scarpa, Vladimir Luca Pozner, Søren Skov , et al. · 2021

Introduction The use of photobiomodulation has been proposed to improve wound healing for the last two decades. Recent development in photobiomodulation has led to the development of a novel biophotonic platform that utilizes fluorescent l…

Effective removal of solar lentigines by combination of pre– And post–fluorescent light energy treatment with picosecond laser treatment Open

G. Scarcella, Peter Arne Gerber, Deirdre Edge, Michael Engelbrecht Nielsen · 2020

We present a novel treatment for removal of SL that is efficient and enables removal or lesions not immediately visible. Kleresca ® FLE technology combined with picosecond laser treatment removes SL lesions and improves skin quality and ap…

Fluorescent light energy in wound healing: when is a photon something more? Open

Michela Zago, Mehrnoush Dehghani, Joanna Jaworska, Maiken Mellergaard, Dierdre Edge , et al. · 2020

Fluorescent Light Energy (FLE) is a unique form of photobiomodulation that stimulates healing, reduces inflammation, and alleviates pain. The system works by exciting a chromophore in a topical substrate, which emits FLE with a broad spect…

Fluorescent Light Energy (FLE) Acts on Mitochondrial Physiology Improving Wound Healing Open

Letizia Ferroni, Michela Zago, Simone Patergnani, Shannon E. Campbell, Lise Hébert , et al. · 2020

Fluorescent light energy (FLE) has been used to treat various injured tissues in a non-pharmacological and non-thermal fashion. It was applied to stimulate cell proliferation, accelerate healing in chronic and acute wounds, and reduce pain…

Biophotonic pretreatment enhances the targeting of senile lentigines with a 694 nm QS‐ruby laser Open

Peter Arne Gerber, G. Scarcella, Deirdre Edge, Michael Engelbrecht Nielsen · 2019

The ability of lasers to selectively destroy the melanin pigment responsible for solar/senile lentigines (SL) (age spots) without damaging the surrounding tissue makes laser therapy a preferred option for treating SL.1 However, laser thera…

Fluorescent light energy: A new therapeutic approach to effectively treating acne conglobata and hidradenitis suppurativa Open

Ikonija Koceva, Bettina Rümmelein, Peter Arne Gerber, Deirdre Edge, Michael Engelbrecht Nielsen · 2019

The Kleresca ® biophotonic platform utilizing fluorescent light energy (FLE) effectively treated both acne conglobata and hidradenitis suppurativa. FLE decreased the presence of inflammatory nodules, cysts, and associated erythema. It also…

Astaxanthin from Shrimp Cephalothorax Stimulates the Immune Response by Enhancing IFN-γ, IL-10, and IL-2 Secretion in Splenocytes of Helicobacter Pylori-Infected Mice Open

Sergio Davinelli, Heidi Mikkelsen Melvang, Leif Percival Andersen, Giovanni Scapagnini, Michael Engelbrecht Nielsen · 2019

Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (…

Microtonal Systems and Guitar Composition Open

Michael Engelbrecht Nielsen · 2019

This thesis focuses on the use of microtones in guitar composition. In the course of this study the physical aspects of musical sound (pitch, loudness and quality/timbre), vibrational frequencies of strings, and the theory of musical scale…

FLUORESCENT LIGHT ENERGY: The Future for Treating Inflammatory Skin Conditions? Open

Deirdre Edge, Maiken Mellergaard, Carsten Dam‐Hansen, Dennis Dan Corell, Joanna Jaworska , et al. · 2019

Background: We have previously reported clinical efficacy with a novel form of photobiomodulation—a biophotonic platform inducing fluorescent light energy (FLE)—in both disease-affected and healthy skin; however, the cellular mechanisms re…

Fluorescent light energy: Treating rosacea subtypes 1, 2, and 3 Open

M. Sannino, Giuseppe Lodi, Markus Wied Dethlefsen, Steven Paul Nisticò, Giovanni Cannarozzo , et al. · 2018

Key Clinical Message Kleresca® biophotonic platform utilizing fluorescent light energy effectively decreased the inflammatory and erythematous reaction common in rosacea subtypes 1, 2, and 3. Kleresca® may be considered as a single treatme…

Treatment of solar lentigines using a combination of picosecond laser and biophotonic treatment Open

G. Scarcella, Markus Wied Dethlefsen, Michael Engelbrecht Nielsen · 2018

Key Clinical Message Treating solar lentigines using picosecond‐switched lasers that selectively remove the excess pigment was combined with Kleresca ® biophotonic treatment. This therapy uses fluorescent light energy to stimulate healing …

Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review Open

Sergio Davinelli, Michael Engelbrecht Nielsen, Giovanni Scapagnini · 2018

Astaxanthin, a xanthophyll carotenoid, is a secondary metabolite naturally synthesized by a number of bacteria, microalgae, and yeasts. The commercial production of this pigment has traditionally been performed by chemical synthesis, but t…

Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy Open

Yared Hailemichael, Amber N. Woods, Tihui Fu, Qiuming He, Michael Engelbrecht Nielsen , et al. · 2018

Anticancer vaccination is a promising approach to increase the efficacy of cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed death ligand 1 (PD-L1) checkpoint blockade therapies. However, the landmark FDA registration tri…

Analysis of the production of salmon fillet – Prediction of production yield Open

Gine Ørnholt-Johansson, María Guðjónsdóttir, Michael Engelbrecht Nielsen, Jacob Lercke Skytte, Stina Frosch · 2017

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