Michael Epton
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View article: Variation in clinical presentation, complications and outcomes for Māori and Pacific peoples among hospitalised adults with <scp>COVID</scp>‐19 in 2022, Aotearoa New Zealand
Variation in clinical presentation, complications and outcomes for Māori and Pacific peoples among hospitalised adults with <span>COVID</span>‐19 in 2022, Aotearoa New Zealand Open
Background Pacific region‐specific data on the clinical course of COVID‐19 are limited. We aimed to describe clinical features and outcomes from Aotearoa New Zealand patients, focusing on Māori and Pacific peoples. Methods We conducted a r…
View article: Evaluation of risk prediction scores for adults hospitalized with COVID-19 in a highly-vaccinated population, Aotearoa New Zealand 2022
Evaluation of risk prediction scores for adults hospitalized with COVID-19 in a highly-vaccinated population, Aotearoa New Zealand 2022 Open
Following re-calibration, existing risk prediction scores accurately predicted mortality.
View article: COVID-19–related hospitalizations among Aotearoa, New Zealand children during the Omicron era of SARS-CoV-2
COVID-19–related hospitalizations among Aotearoa, New Zealand children during the Omicron era of SARS-CoV-2 Open
Children hospitalized during the first significant wave of SARS-CoV-2 infection in New Zealand presented with a multi-system viral illness and rarely with severe disease.
View article: Exploring the feasibility of linking historical air pollution data to the Christchurch Health and Development study: A birth cohort study in Aotearoa, New Zealand
Exploring the feasibility of linking historical air pollution data to the Christchurch Health and Development study: A birth cohort study in Aotearoa, New Zealand Open
Spatial life course epidemiological approaches offer promise for prospectively examining the impacts of air pollution exposure on longer-term health outcomes, but existing research is limited. An essential aspect, often overlooked is the c…
View article: Investigating the spatial and temporal variation of vape retailer provision in New Zealand: A cross-sectional and nationwide study
Investigating the spatial and temporal variation of vape retailer provision in New Zealand: A cross-sectional and nationwide study Open
Smoking rates have decreased in Aotearoa New Zealand in recent years however, vaping has shown a dramatic upward trend especially among young people; up to 10% of young New Zealanders are now regular vapers. Importantly, the long-term heal…
View article: Investigating the spatial and temporal variation of vape retailer provision in New Zealand: a cross-sectional and nationwide study
Investigating the spatial and temporal variation of vape retailer provision in New Zealand: a cross-sectional and nationwide study Open
We know little about the spatial patterning of e-cigarette retailers, particularly their socio-spatial patterning around schools. We obtained the nationwide vape retail locations from the Specialist Vape Retailers register, New Zealand. We…
View article: Adjunctive intravenous then oral vitamin C for moderate and severe community-acquired pneumonia in hospitalized adults: feasibility of randomized controlled trial
Adjunctive intravenous then oral vitamin C for moderate and severe community-acquired pneumonia in hospitalized adults: feasibility of randomized controlled trial Open
Patients hospitalised with community acquired pneumonia (CAP) have low peripheral blood vitamin C concentrations and limited antioxidant capacity. The feasibility of a trial of vitamin C supplementation to improve patient outcomes was asse…
View article: DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight Open
Background Individuals born very low birthweight (VLBW) are at increased risk of impaired cardiovascular and respiratory function in adulthood. To identify markers to predict future risk for VLBW individuals, we analyzed DNA methylation at…
View article: Additional file 7 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
Additional file 7 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight Open
Additional file 7: Table S3. Differentially methylated regions (DMRs) that were significant (FDR adj-p<0.05), with DMRs in neonatal samples on the first worksheet and DMRs identified in adult samples on the second worksheet.
View article: Additional file 4 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
Additional file 4 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight Open
Additional file 4: Table S2. Full list of 16407 CpGs with methylation that differed between VLBW cases and controls after adjusting for false discovery rate (Benjamini-Hochberg FDR adj-p<0.05).
View article: Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease
Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease Open
Importance Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing is needed. Objecti…
View article: DNA Methylation Patterns At Birth Predict Health Outcomes In Young Adults Born Very Low Birthweight
DNA Methylation Patterns At Birth Predict Health Outcomes In Young Adults Born Very Low Birthweight Open
Background Individuals born very low birthweight (VLBW) are at increased risk of impaired cardiovascular and respiratory function in adulthood. To identify markers to predict future risk for VLBW individuals, we analysed DNA methylation at…
View article: Symptom persistence and recovery among COVID‐19 survivors during a limited outbreak in Canterbury, New Zealand: a prospective cohort study
Symptom persistence and recovery among COVID‐19 survivors during a limited outbreak in Canterbury, New Zealand: a prospective cohort study Open
Background In Canterbury, near complete identification of coronavirus disease 2019 (COVID‐19) cases during a limited outbreak provides unique insights into sequelae. Aims The current study aimed to measure symptom persistence, time to retu…
View article: Drug metabolism in severe chronic obstructive pulmonary disease: A phenotyping <i>cocktail</i> study
Drug metabolism in severe chronic obstructive pulmonary disease: A phenotyping <i>cocktail</i> study Open
Aims To evaluate the effect of severe chronic obstructive pulmonary disease (COPD) on drug metabolism by comparing the pharmacokinetics of patients with severe COPD with healthy volunteers and using the modified Inje drug cocktail. Methods…
View article: Drug Metabolism in Severe Chronic Obstructive Pulmonary Disease: A Phenotyping ‘Cocktail’ Study
Drug Metabolism in Severe Chronic Obstructive Pulmonary Disease: A Phenotyping ‘Cocktail’ Study Open
Aims To evaluate the effect of severe chronic obstructive pulmonary disease (COPD) on drug metabolism by comparing the pharmacokinetics of patients with severe COPD with healthy volunteers and using the modified ‘Inje’ drug cocktail. Metho…
View article: Continuous Positive Airway Pressure Treatment, Glycemia, and Diabetes Risk in Obstructive Sleep Apnea and Comorbid Cardiovascular Disease
Continuous Positive Airway Pressure Treatment, Glycemia, and Diabetes Risk in Obstructive Sleep Apnea and Comorbid Cardiovascular Disease Open
OBJECTIVE Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve metabolic parameters. We sought to determine effects of long-term co…
View article: Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis
Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis Open
Calprotectin, the major neutrophil protein, is a critical alarmin that modulates inflammation and plays a role in host immunity by strongly binding trace metals essential for bacterial growth. It has two cysteine residues favourably positi…
View article: Winter Is Coming: A Socio-Environmental Monitoring and Spatiotemporal Modelling Approach for Better Understanding a Respiratory Disease
Winter Is Coming: A Socio-Environmental Monitoring and Spatiotemporal Modelling Approach for Better Understanding a Respiratory Disease Open
Chronic Obstructive Pulmonary Disease is a progressive lung disease affecting the respiratory function of every sixth New Zealander and over 300 million people worldwide. In this paper, we explored how the combination of social, demographi…
View article: Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial
Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial Open
Low vitamin D status is associated with increased risk of pneumonia, greater disease severity and poorer outcome. However, no trials have examined the effect of adjunctive vitamin D therapy on outcomes in adults with community-acquired pne…
View article: Reducing hospital admissions for COPD: perspectives following the Christchurch Earthquake
Reducing hospital admissions for COPD: perspectives following the Christchurch Earthquake Open
The devastating 2011 earthquake in Christchurch destroyed or badly damaged healthcare infrastructure, including Christchurch Hospital. This forced change in management of exacerbations of chronic obstructive pulmonary disease (COPD), which…
View article: Do self-management interventions in COPD patients work and which patients benefit most? An individual patient data meta-analysis
Do self-management interventions in COPD patients work and which patients benefit most? An individual patient data meta-analysis Open
Self-management interventions exert positive effects in patients with COPD on respiratory-related and all-cause hospitalizations and modest effects on 12-month health-related quality of life, supporting the implementation of self-managemen…
View article: REAL-TIME ENVIRONMENTAL SENSORS TO IMPROVE HEALTH IN THE SENSING CITY
REAL-TIME ENVIRONMENTAL SENSORS TO IMPROVE HEALTH IN THE SENSING CITY Open
The opportunity of an emerging smart city in post-disaster Christchurch has been explored as a way to improve the quality of life of people suffering Chronic Obstructive Pulmonary Disease (COPD), which is a progressive disease that affects…
View article: REAL-TIME ENVIRONMENTAL SENSORS TO IMPROVE HEALTH IN THE SENSING CITY
REAL-TIME ENVIRONMENTAL SENSORS TO IMPROVE HEALTH IN THE SENSING CITY Open
The opportunity of an emerging smart city in post-disaster Christchurch has been explored as a way to improve the quality of life of people suffering Chronic Obstructive Pulmonary Disease (COPD), which is a progressive disease that affects…
View article: Characteristics of effective self-management interventions in patients with COPD: individual patient data meta-analysis
Characteristics of effective self-management interventions in patients with COPD: individual patient data meta-analysis Open
It is unknown whether heterogeneity in effects of self-management interventions in patients with chronic obstructive pulmonary disease (COPD) can be explained by differences in programme characteristics. This study aimed to identify which …