Michael F. Flessner
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View article: High-resolution surface and rootzone soil moisture over US cropland: A novel framework assimilating multi-source remote sensing data, machine learning, and the Layered Green and Ampt Infiltration with Redistribution model
High-resolution surface and rootzone soil moisture over US cropland: A novel framework assimilating multi-source remote sensing data, machine learning, and the Layered Green and Ampt Infiltration with Redistribution model Open
View article: African Ancestry–Specific Alleles and Kidney Disease Risk in Hispanics/Latinos
African Ancestry–Specific Alleles and Kidney Disease Risk in Hispanics/Latinos Open
African ancestry alleles may contribute to CKD among Hispanics/Latinos, but whether associations differ by Hispanic/Latino background remains unknown. We examined the association of CKD measures with African ancestry-specific APOL1
View article: Acculturation and chronic kidney disease in the Hispanic community health study/study of Latinos (HCHS/SOL)
Acculturation and chronic kidney disease in the Hispanic community health study/study of Latinos (HCHS/SOL) Open
View article: Deep Learning–Based Automated Imaging Classification of ADPKD
Deep Learning–Based Automated Imaging Classification of ADPKD Open
View article: NFAT5 and SLC4A10 loci associate with plasma osmolality
NFAT5 and SLC4A10 loci associate with plasma osmolality Open
Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study me…
View article: Targeting Gut Microbiome With Prebiotic in Patients With CKD: The TarGut-CKD Study
Targeting Gut Microbiome With Prebiotic in Patients With CKD: The TarGut-CKD Study Open
View article: Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity
Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity Open
Supplemental Data Supplemental Data include five figures, fourteen tables, and Supplemental Acknowledgments and can be found with this article online at http://dx.doi.org/10.1016/j.ajhg.2016.07.012. Supplemental Data Document S1. Figures S…
View article: Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos
Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos Open
Intermittent smoking is prevalent among Hispanics, but little is known about whether this smoking pattern associates with increased chronic kidney disease (CKD) risk in this population. The objective of the present study is to identify pat…
View article: A Randomized Trial Comparing the Safety, Adherence, and Pharmacodynamics Profiles of Two Doses of Sodium Bicarbonate in CKD: the BASE Pilot Trial
A Randomized Trial Comparing the Safety, Adherence, and Pharmacodynamics Profiles of Two Doses of Sodium Bicarbonate in CKD: the BASE Pilot Trial Open
Significance Statement Oral sodium bicarbonate supplementation may preserve kidney function in patients with CKD. However, the best dose to use in phase-3 trials testing this hypothesis is uncertain. The authors conducted a multicenter pil…
View article: Preventing Early Renal Loss in Diabetes (PERL) Study: A Randomized Double-Blinded Trial of Allopurinol—Rationale, Design, and Baseline Data
Preventing Early Renal Loss in Diabetes (PERL) Study: A Randomized Double-Blinded Trial of Allopurinol—Rationale, Design, and Baseline Data Open
OBJECTIVE Higher serum uric acid (SUA) is associated with diabetic kidney disease (DKD). Preventing Early Renal Loss in Diabetes (PERL) evaluates whether lowering SUA with allopurinol slows glomerular filtration rate (GFR) loss in people w…
View article: Effects of Nicotinamide and Lanthanum Carbonate on Serum Phosphate and Fibroblast Growth Factor-23 in CKD: The COMBINE Trial
Effects of Nicotinamide and Lanthanum Carbonate on Serum Phosphate and Fibroblast Growth Factor-23 in CKD: The COMBINE Trial Open
Significance Statement Higher serum phosphate and fibroblast growth factor-23 (FGF23) levels are potential modifiable risk factors to prevent cardiovascular disease in CKD. Studies evaluating intestinal phosphate binders found modest effic…
View article: CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease
CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease Open
View article: Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components
Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components Open
Background Ultrafiltration failure (UFF) in peritoneal dialysis (PD) patients is due to altered peritoneal transport properties leading to reduced capacity to remove excess water. Here, with the aim to establish the role of local alteratio…
View article: Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study
Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study Open
View article: Giant Hogweed: Identification and Control
Giant Hogweed: Identification and Control Open
Discusses how to identify Giant Hogweed, risks to people who come in contact with this plant, and discusses ways to control it.
View article: FP803EFFECTS OF NICOTINAMIDE AND LANTHANUM CARBONATE ON SERUM PHOSPHATE AND FGF23 CONCENTRATIONS IN CHRONIC KIDNEY DISEASE: PRIMARY RESULTS OF THE COMBINE TRIAL
FP803EFFECTS OF NICOTINAMIDE AND LANTHANUM CARBONATE ON SERUM PHOSPHATE AND FGF23 CONCENTRATIONS IN CHRONIC KIDNEY DISEASE: PRIMARY RESULTS OF THE COMBINE TRIAL Open
View article: Acculturation and chronic kidney disease in the Hispanic community health study/study of Latinos (HCHS/SOL)
Acculturation and chronic kidney disease in the Hispanic community health study/study of Latinos (HCHS/SOL) Open
View article: Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study
Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study Open
Whether elevated uric acid ( UA ) is an independent risk factor for chronic kidney disease ( CKD ) is not well established. The authors evaluated the relationship of UA with rapid kidney function decline ( RKFD ) and incident CKD among 370…
View article: Longitudinal Assessment of Left Ventricular Mass in Autosomal Dominant Polycystic Kidney Disease
Longitudinal Assessment of Left Ventricular Mass in Autosomal Dominant Polycystic Kidney Disease Open
Characteristics associated with higher risk of progression in ADPKD, including higher systolic blood pressure, larger kidney volume, and lower eGFR are associated with improvement in LVMI with intensive blood pressure control, whereas male…
View article: Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials
Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials Open
View article: Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease
Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease Open
View article: ADPKD Progression in Patients With No Apparent Family History and No Mutation Detected by Sanger Sequencing
ADPKD Progression in Patients With No Apparent Family History and No Mutation Detected by Sanger Sequencing Open
View article: A Patient With CKD Develops Cholestatic Liver Injury During a Clinical Trial
A Patient With CKD Develops Cholestatic Liver Injury During a Clinical Trial Open
View article: Effect of Statin Therapy on the Progression of Autosomal Dominant Polycystic Kidney Disease. A Secondary Analysis of the HALT PKD Trials
Effect of Statin Therapy on the Progression of Autosomal Dominant Polycystic Kidney Disease. A Secondary Analysis of the HALT PKD Trials Open
Although this post-hoc analysis of the HALT PKD trials does not demonstrate a benefit of statin therapy, conclusions remain preliminary. A larger randomized trial in young people with ADPKD is necessary to answer the question whether stati…
View article: NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality
NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality Open
Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study me…
View article: Performance of the CKD-EPI Equation to Estimate GFR in a Longitudinal Study of Autosomal Dominant Polycystic Kidney Disease
Performance of the CKD-EPI Equation to Estimate GFR in a Longitudinal Study of Autosomal Dominant Polycystic Kidney Disease Open
View article: Dietary salt restriction is beneficial to the management of autosomal dominant polycystic kidney disease
Dietary salt restriction is beneficial to the management of autosomal dominant polycystic kidney disease Open
View article: Pharmacokinetic problems in peritoneal drug administration: an update after 20 years
Pharmacokinetic problems in peritoneal drug administration: an update after 20 years Open
Intraperitoneal chemotherapy has demonstrated significant pharmacologic and clinical advantage over traditional intravenous administration for cancers that are restricted to the peritoneal cavity. The combination of cytoreductive surgery w…
View article: Automated segmentation of liver and liver cysts from bounded abdominal MR images in patients with autosomal dominant polycystic kidney disease
Automated segmentation of liver and liver cysts from bounded abdominal MR images in patients with autosomal dominant polycystic kidney disease Open
Liver and liver cyst volume measurements are important quantitative imaging biomarkers for assessment of disease progression in autosomal dominant polycystic kidney disease (ADPKD) and polycystic liver disease (PLD). To date, no study has …
View article: Glomerular Diseases: Registries and Clinical Trials
Glomerular Diseases: Registries and Clinical Trials Open
Nephrology has conducted few high–quality clinical trials, and the trials that have been conducted have not resulted in the approval of new treatments for primary or inflammatory glomerular diseases. There are overarching process issues th…