Michael F. Gates
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View article: A novel homoarginine-containing cyclic peptide pioamide with selective antipseudomonal activity isolated from the nematode symbiont <i>Photorhabdus khanii</i>
A novel homoarginine-containing cyclic peptide pioamide with selective antipseudomonal activity isolated from the nematode symbiont <i>Photorhabdus khanii</i> Open
Gram-negative bacteria harbor an outer membrane that physically protects them from the penetration of antibiotics into the cells. This barrier makes it challenging to develop antibiotics that effectively kill Gram-negative pathogens. The e…
View article: Bacterial membrane vesicles restore gut anaerobiosis
Bacterial membrane vesicles restore gut anaerobiosis Open
Inflammation damages the epithelial cell barrier, allowing oxygen to leak into the lumen of the gut. Respiring E. coli and other Enterobacteriaceae produce proinflammatory lipopolysaccharide, exacerbating inflammatory bowel disease. Here w…
View article: Author Correction: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
Author Correction: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis Open
View article: Small molecule produced by <i>Photorhabdus</i> interferes with ubiquinone biosynthesis in Gram-negative bacteria
Small molecule produced by <i>Photorhabdus</i> interferes with ubiquinone biosynthesis in Gram-negative bacteria Open
We report the identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus , whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching…
View article: Computational identification of a systemic antibiotic for Gram-negative bacteria
Computational identification of a systemic antibiotic for Gram-negative bacteria Open
View article: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis Open
View article: A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP
A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP Open
Drug-resistant Gram-negative bacteria have become the major problem driving the antimicrobial resistance crisis. Searching outside the overmined actinomycetes, we focused on Photorhabdus , gut symbionts of enthomopathogenic nematodes that …
View article: Pulse Dosing of Antibiotic Enhances Killing of a Staphylococcus aureus Biofilm
Pulse Dosing of Antibiotic Enhances Killing of a Staphylococcus aureus Biofilm Open
Biofilms are highly tolerant to antibiotics and underlie the recalcitrance of many chronic infections. We demonstrate that mature Staphylococcus aureus biofilms can be substantially sensitized to the treatment by pulse dosing of an …