Michael F. Good
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View article: Rapid screening for acute rheumatic fever using machine learning analysis of host tissue reactive antibodies
Rapid screening for acute rheumatic fever using machine learning analysis of host tissue reactive antibodies Open
Acute Rheumatic Fever and Rheumatic Heart Disease (ARF/RHD) affect over 45 million people globally. ARF/RHD are autoimmune complications following group A streptococcal infections. Current diagnosis of ARF requires thorough medical examina…
View article: Phase I Trial of a Peptide-Based Vaccine to Prevent Group A Streptococcal Infection
Phase I Trial of a Peptide-Based Vaccine to Prevent Group A Streptococcal Infection Open
View article: Low-Dose Interleukin-2 Therapy: A Transformative Approach for the Management of Autoimmune Complications Associated with Streptococcus pyogenes Infections
Low-Dose Interleukin-2 Therapy: A Transformative Approach for the Management of Autoimmune Complications Associated with Streptococcus pyogenes Infections Open
View article: Delineating Humoral and Cellular Immune Responses Induced by a Peptide-Based Vaccine for Protection Against Streptococcus pyogenes
Delineating Humoral and Cellular Immune Responses Induced by a Peptide-Based Vaccine for Protection Against Streptococcus pyogenes Open
View article: Human Antibodies to M-Protein Epitope-Based Vaccines Demonstrate Increased Immunogenicity and Streptococcus pyogenes (StrepA) Bactericidal Activity
Human Antibodies to M-Protein Epitope-Based Vaccines Demonstrate Increased Immunogenicity and Streptococcus pyogenes (StrepA) Bactericidal Activity Open
View article: Parenteral Vaccination with a Super Immunogen Targeting M-Protein Provides Unprecedented Protection Against Group A Streptococcus (StrepA) Respiratory Infections
Parenteral Vaccination with a Super Immunogen Targeting M-Protein Provides Unprecedented Protection Against Group A Streptococcus (StrepA) Respiratory Infections Open
View article: Subclinical exposure to Streptococcus pyogenes drives the development of long-lived immunity
Subclinical exposure to Streptococcus pyogenes drives the development of long-lived immunity Open
Age-related decline in Streptococcus pyogenes infection rates suggests that immunity develops progressively through repeated exposure during early life. However, the intensity or duration of exposure required is unknown, as to why some ind…
View article: Sub-clinical exposure to <i>Streptococcus pyogenes</i> drives the development of immunity
Sub-clinical exposure to <i>Streptococcus pyogenes</i> drives the development of immunity Open
Summary Age-related decline in Streptococcus pyogenes infection rates suggests that immunity develops progressively through repeated exposure during early life. However, the intensity or duration of exposure required is unknown, as to why …
View article: Inflammatory Responses Potentiate GAS M Protein Induced Cardiac Damage in an Experimental Model of Rheumatic Heart Disease
Inflammatory Responses Potentiate GAS M Protein Induced Cardiac Damage in an Experimental Model of Rheumatic Heart Disease Open
Aim Acute rheumatic fever (ARF) and Rheumatic heart disease (RHD) are autoimmune sequalae, that develops in a proportion of individuals exposed to group A streptococcal infection. The autoimmune pathology of ARF/RHD is multifactorial. Both…
View article: Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease
Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease Open
Acute rheumatic fever (ARF) is an autoimmune disease triggered by antibodies and T cells targeting the group A Streptococcus (GAS, Strep A) bacterium, often leading to rheumatic heart disease (RHD) and Sydenham’s chorea. Long-term monthly …
View article: Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections Open
View article: A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers
A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers Open
View article: Immunotherapeutic strategy to prevent progression and complications of acute rheumatic fever
Immunotherapeutic strategy to prevent progression and complications of acute rheumatic fever Open
Acute rheumatic fever (ARF) is an autoimmune disease triggered by antibodies and T-cells targeting the Group A streptococcal (GAS, Strep A) bacterium, often leading to rheumatic heart disease (RHD). Long-term antibiotic therapy is recogniz…
View article: Chimeric hepatitis B surface antigen virus-like particles expressing the strep A epitope p*17 elicit a humoral immune response in mice
Chimeric hepatitis B surface antigen virus-like particles expressing the strep A epitope p*17 elicit a humoral immune response in mice Open
View article: Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model
Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model Open
Vaccine development against group A Streptococcus (GAS) has gained traction in the last decade, fuelled by recognition of the significant worldwide burden of the disease. Several vaccine candidates are currently being evaluated in preclini…
View article: Disruption of IL-17-mediated immunosurveillance in the respiratory mucosa results in invasive Streptococcus pyogenes infection
Disruption of IL-17-mediated immunosurveillance in the respiratory mucosa results in invasive Streptococcus pyogenes infection Open
Introduction Streptococcus pyogenes is a Gram-positive pathogen that causes a significant global burden of skin pyoderma and pharyngitis. In some cases, infection can lead to severe invasive streptococcal diseases. Previous studies have sh…
View article: Disruption of IL-17 signaling in the respiratory mucosa results in invasive streptococcal infection
Disruption of IL-17 signaling in the respiratory mucosa results in invasive streptococcal infection Open
Streptococcus pyogenes infection of the upper respiratory tract and skin can lead to severe invasive streptococcal disease (ISD). Previous studies have demonstrated that the deficiency of IL-17 in mice (IL-17-/-) reduces mucosal immunity a…
View article: A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4 <sup>+</sup> T-cell-dependent strain-transcending protective immunity in rodent models
A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4 <sup>+</sup> T-cell-dependent strain-transcending protective immunity in rodent models Open
Malaria is a leading cause of illness and death in children under 5 years of age in Sub-Saharan Africa. Currently, there is no highly efficacious malaria vaccine capable of inducing long-lasting immunity. This has increased interest in exp…
View article: A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils
A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils Open
View article: Malaria Vaccines: Progress to Date
Malaria Vaccines: Progress to Date Open
View article: Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine Open
View article: Exploring the landscape of Babesia bovis vaccines: progress, challenges, and opportunities
Exploring the landscape of Babesia bovis vaccines: progress, challenges, and opportunities Open
View article: Polymeric epitope-based vaccine induces protective immunity against group A Streptococcus
Polymeric epitope-based vaccine induces protective immunity against group A Streptococcus Open
Group A Streptococcus (Strep A) is a life-threatening human pathogen with no licensed vaccine. Here, we used a biopolymer particle (BP) approach to display repeats of Strep A vaccine candidate peptides p*17 and K4S2 derived from M and non-…
View article: Streptolysin O Deficiency in Streptococcus pyogenes M1T1 <i>covR/S</i> Mutant Strain Attenuates Virulence in <i>In Vitro</i> and <i>In Vivo</i> Infection Models
Streptolysin O Deficiency in Streptococcus pyogenes M1T1 <i>covR/S</i> Mutant Strain Attenuates Virulence in <i>In Vitro</i> and <i>In Vivo</i> Infection Models Open
Streptococcus pyogenes is responsible for significant numbers of invasive and noninvasive infections which cause significant morbidity and mortality globally. Strep A isolates with mutations in the covR/S system display greater propensity …
View article: Streptococcus pyogenes vaccine candidates do not induce autoimmune responses in a rheumatic heart disease model
Streptococcus pyogenes vaccine candidates do not induce autoimmune responses in a rheumatic heart disease model Open
View article: Assembly of Immunogenic Protein Particles toward Advanced Synthetic Vaccines
Assembly of Immunogenic Protein Particles toward Advanced Synthetic Vaccines Open
Immunogenic carrier proteins such as the non‐toxic diphtheria toxin variant, cross‐reacting material 197 (CRM197), are widely used in subunit vaccine formulations to boost immunogenicity of chemically conjugated antigens. Conjugate vaccine…
View article: Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation
Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation Open
Peptide-based vaccines are composed of minimal microbial components that are required to stimulate immune responses. Peptide antigens are easy to produce, relatively cheap and non-toxic. They are also able to activate the immune system in …
View article: A vaccine for human babesiosis: prospects and feasibility
A vaccine for human babesiosis: prospects and feasibility Open
View article: Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens
Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens Open
Malaria is a vector born parasitic disease causing millions of deaths every year. Despite the high mortality rate, an effective vaccine against this mosquito-borne infectious disease is yet to be developed. Up to date, RTS,S/AS01 is the on…
View article: Vaccinating Children against COVID-19: Commentary and Mathematical Modeling
Vaccinating Children against COVID-19: Commentary and Mathematical Modeling Open
Countries have recently begun implementation of childhood vaccination against SARS-CoV-2 with the Pfizer/BioNTech mRNA vaccine in children 5 to 11 years of age. Because SARS-CoV-2 disease severity is remarkably age dependent, vaccinating c…