Michael F. Harrison
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View article: 100 DEFRAIL: The Development of a Patient-centred, Theory-informed, Expert-guided Diet and Exercise for Frailty Intervention
100 DEFRAIL: The Development of a Patient-centred, Theory-informed, Expert-guided Diet and Exercise for Frailty Intervention Open
Purpose Combined exercise and dietary interventions have been shown to benefit older adults with frailty, with significant promise in transitioning between frailty states. However, there is limited availability of such interventions, partl…
View article: Determinants of physical activity promotion in primary care from the patient perspective of people at risk of or living with chronic disease: a COM-B analysis
Determinants of physical activity promotion in primary care from the patient perspective of people at risk of or living with chronic disease: a COM-B analysis Open
View article: 202. Association of Neutrophil - Lymphocyte Ratio with Bacteremia and In-Hospital Mortality in Sepsis Patients: A Retrospective Multicenter Study
202. Association of Neutrophil - Lymphocyte Ratio with Bacteremia and In-Hospital Mortality in Sepsis Patients: A Retrospective Multicenter Study Open
Background Early diagnosis, prognostication, and treatment initiation are the cornerstones of sepsis management. There remains an immense interest in exploring the diagnostic and prognostic roles of neutrophil-lymphocyte ratio (NLR) in the…
View article: ST-elevation myocardial infarction after thrombolytic therapy with Tenecteplase for acute ischaemic stroke
ST-elevation myocardial infarction after thrombolytic therapy with Tenecteplase for acute ischaemic stroke Open
Myocardial infarction (MI) secondary to thrombolytic therapy in the setting of acute ischaemic stroke (AIS) is a rare but severe complication. This phenomenon has been well documented in the past with recombinant tissue-type plasminogen ac…
View article: A retrospective analysis of normal saline and lactated ringers as resuscitation fluid in sepsis
A retrospective analysis of normal saline and lactated ringers as resuscitation fluid in sepsis Open
Background The Surviving Sepsis Campaign suggested preferential resuscitation with balanced crystalloids, such as Lactated Ringer’s (LR), although the level of recommendation was weak, and the quality of evidence was low. Past studies repo…
View article: Impact of Hospital Safety-Net Burden on Outcomes of In-Hospital Cardiac Arrest in the United States
Impact of Hospital Safety-Net Burden on Outcomes of In-Hospital Cardiac Arrest in the United States Open
IMPORTANCE: High safety-net burden hospitals (HBHs) treating large numbers of uninsured or Medicaid-insured patients have generally been linked to worse clinical outcomes. However, limited data exist on the impact of the hospitals’ safety-…
View article: Surviving Sepsis Guideline–Directed Fluid Resuscitation: An Assessment of Practice Patterns and Impact on Patient Outcomes
Surviving Sepsis Guideline–Directed Fluid Resuscitation: An Assessment of Practice Patterns and Impact on Patient Outcomes Open
IMPORTANCE: Aggressive fluid resuscitation remains a cornerstone of the Surviving Sepsis Campaign (SSC) guidelines, but there is growing controversy regarding the recommended 30 mL/kg IV fluid dosage. It is contended that, in selected pati…
View article: Inhaled nitric oxide use in COVID19-induced hypoxemic respiratory failure
Inhaled nitric oxide use in COVID19-induced hypoxemic respiratory failure Open
Introduction Nitric Oxide (NO) is an endogenous vasodilator that is synthesized by the vascular endothelium. Due to its vasodilatory effect and short half-life, the use of NO as an exogenous inhaled medication (iNO) to target the pulmonary…
View article: Massive Pulmonary Embolism Causing Cardiac Arrest Managed with Systemic Thrombolytic Therapy: A Case Report
Massive Pulmonary Embolism Causing Cardiac Arrest Managed with Systemic Thrombolytic Therapy: A Case Report Open
BACKGROUND Approximately 290 000 cases of in-hospital cardiac arrest occur annually, the majority of which are due to cardiac or respiratory causes. Cardiac arrest due to acute pulmonary embolism (PE) is associated with a 90% incidence of …
View article: A Case of COVID-19 Re-Infection in a Liver Transplant Patient
A Case of COVID-19 Re-Infection in a Liver Transplant Patient Open
Coronavirus disease 2019 (COVID-19) is an ongoing worldwide pandemic infection. The exact incidence of disease re-infection or recurrence remains unknown. One particular at-risk population includes individuals with solid organ transplantat…
View article: A Delayed Case of Pericarditis Following Recovery From COVID-19 Infection
A Delayed Case of Pericarditis Following Recovery From COVID-19 Infection Open
Pericarditis is a rare cardiac complication of coronavirus 19 (COVID-19) infection. Recent case reports describe severe sequelae of pericarditis, including cardiac tamponade, developing within days of initial COVID-19 symptoms. We present …
View article: Oxygen therapy via a noninvasive helmet: A COVID-19 novelty with potential post-pandemic uses
Oxygen therapy via a noninvasive helmet: A COVID-19 novelty with potential post-pandemic uses Open
COVID-19 has placed a significant strain upon healthcare resources at a global level and refractory hypoxemia is the leading cause of death among COVID-19 patients. The management of limited resources such as mechanical ventilators has rem…
View article: Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research
Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research Open
View article: Cardiac Arrest Due to Severe Dynamic Left Ventricular Outflow Obstruction and Hypertrophy Following Anesthesia Induction
Cardiac Arrest Due to Severe Dynamic Left Ventricular Outflow Obstruction and Hypertrophy Following Anesthesia Induction Open
Cardiac arrest following induction of general anesthesia is a rare event. A 47-year-old woman with a history of chronic neck pain secondary to spinal stenosis presented for elective cervical laminectomy. Induction of general anesthesia ind…
View article: A Novel Curriculum for Ophthalmology Training of Emergency Medicine Residents (COPTER)
A Novel Curriculum for Ophthalmology Training of Emergency Medicine Residents (COPTER) Open
Author(s): Bouman, A; Goyal, N; Guyer, C; Goyal, A; Huitsing, H; Dowers, C; Clark, C; Noll, S; Harrison, M; Stokes-Buzzelli, S
View article: A Plumb Fit
A Plumb Fit Open
View article: Henry Ford HEART Score Randomized Trial
Henry Ford HEART Score Randomized Trial Open
Background— Hospital evaluation of patients with chest pain is common and costly. The HEART score risk stratification tool that merges troponin testing into a clinical risk model for evaluation emergency department patients with possible a…
View article: Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide
Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide Open
Acetazolamide during rapid ascent provided no apparent protection from AMS based on LLSS. However, it is unclear if this lack of effect was directly associated with the drug or if perhaps there was some selection bias with individuals taki…
View article: The National Exercise Referral Framework
The National Exercise Referral Framework Open
The World Health Organisation published a European Physical Activity for Health
Strategy in 2015; its purpose is to inspire governments and stakeholders to work
towards increasing levels of physical activity among all citizens of the Eur…