Michael Fragkiadakis
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View article: Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex
Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex Open
View article: Diving into the Shielding Surfaces: Construction of Atropisomeric Axes via Multicomponent Reactions
Diving into the Shielding Surfaces: Construction of Atropisomeric Axes via Multicomponent Reactions Open
The CH⋅⋅⋅π interaction, characterized by a CH group acting as a hydrogen bond donor and π electrons serving as the acceptor, shares structural similarities with hydrogen bond and plays a significant role in a multitude of molecular systems…
View article: Rapid scaffold-hopping for molecular glues: from fragments to cell-active probes targeting the 14-3-3/ERα complex
Rapid scaffold-hopping for molecular glues: from fragments to cell-active probes targeting the 14-3-3/ERα complex Open
Molecular glues, small molecules that bind cooperatively at a protein-protein interface, have emerged as powerful modalities for the modulation of protein-protein interactions (PPIs) and “undruggable” targets. The systematic identification…
View article: Navigating Unexplored Territories of the Interrupted Ugi and Passerini Reactions toward Peptidomimetics
Navigating Unexplored Territories of the Interrupted Ugi and Passerini Reactions toward Peptidomimetics Open
Interrupted reactions redirect established processes, often resulting in unexpected and novel outcomes. By employing a building block containing both acidic and oxo functionalities tethered to the same carbon, we uncovered interrupted vari…
View article: CCDC 2294775: Experimental Crystal Structure Determination
CCDC 2294775: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2294777: Experimental Crystal Structure Determination
CCDC 2294777: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2294778: Experimental Crystal Structure Determination
CCDC 2294778: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2294776: Experimental Crystal Structure Determination
CCDC 2294776: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2175580: Experimental Crystal Structure Determination
CCDC 2175580: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2267935: Experimental Crystal Structure Determination
CCDC 2267935: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2267934: Experimental Crystal Structure Determination
CCDC 2267934: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2267933: Experimental Crystal Structure Determination
CCDC 2267933: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: C1 functionalization of imidazo heterocycles <i>via</i> carbon dioxide fixation
C1 functionalization of imidazo heterocycles <i>via</i> carbon dioxide fixation Open
Access to N-heteroaryl 6-, 8- and 9-membered carbamates via carbon dioxide fixation.
View article: β-Borylation of conjugated carbonyl compounds with silylborane or bis(pinacolato)diboron catalyzed by Au nanoparticles
β-Borylation of conjugated carbonyl compounds with silylborane or bis(pinacolato)diboron catalyzed by Au nanoparticles Open
β-Borylation occurs in the Au/TiO2-catalysed reaction between the silylborane Me2PhSiBpin and conjugated carbonyl compounds, in contrast to the so far known analogous reaction catalysed by other metals, where β-silyla…