Michaël Furian
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View article: Self-monitoring symptoms and pulse oximetry to predict imminent altitude illness in patients with chronic obstructive pulmonary disease
Self-monitoring symptoms and pulse oximetry to predict imminent altitude illness in patients with chronic obstructive pulmonary disease Open
Lowlanders with COPD ascending to 3100 m commonly experience ARAHE. Due to its high positive predictive value, performing SSM may allow patients to predict imminent ARAHE and take timely appropriate actions such as descend or use oxygen. N…
View article: Cerebral, Muscle and Blood Oxygenation in Patients with Pulmonary Vascular Disease Whilst Breathing Normobaric Hypoxia vs. Normoxia Before and After Sildenafil: Data from a Randomised Controlled Trial
Cerebral, Muscle and Blood Oxygenation in Patients with Pulmonary Vascular Disease Whilst Breathing Normobaric Hypoxia vs. Normoxia Before and After Sildenafil: Data from a Randomised Controlled Trial Open
Background: In patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (summarized as pulmonary vascular disease; PVD), it is unclear whether the brain is protected against acute hypoxia and whether a…
View article: Effect of short-term supplemental oxygen therapy on six-minute walk distance in highlanders at risk for pulmonary hypertension: a randomized, crossover trial
Effect of short-term supplemental oxygen therapy on six-minute walk distance in highlanders at risk for pulmonary hypertension: a randomized, crossover trial Open
Background Little is known about the effects of portable supplemental oxygen therapy (SOT) to improve exercise performance in highlanders at risk for high altitude pulmonary hypertension (HAPH). We aimed to investigate whether SOT improves…
View article: Patient demographics, medical factors, treatment modalities and satisfaction at five traditional Chinese medicine practices in Switzerland: A cross-sectional study
Patient demographics, medical factors, treatment modalities and satisfaction at five traditional Chinese medicine practices in Switzerland: A cross-sectional study Open
Background Traditional Chinese Medicine (TCM) is increasingly integrated into healthcare and insurance systems, therefore, it is essential to understand its current status and patients’ perspectives. Methods This cross-sectional study was …
View article: Effect of Acetazolamide on Pulmonary Hemodynamics and Right Heart Function in Healthy Adults Going to Altitude: A Randomized Controlled Trial
Effect of Acetazolamide on Pulmonary Hemodynamics and Right Heart Function in Healthy Adults Going to Altitude: A Randomized Controlled Trial Open
Background Exposure to high altitude triggers hypoxic pulmonary vasoconstriction with a rise in pulmonary artery pressure (PAP). This may lead to symptomatic pulmonary hypertension with impaired right heart function and exercise capacity. …
View article: The Effect of Eccentric Cycling on Cerebral and Muscle Tissue Oxygenation in Patients with Pulmonary Hypertension and Healthy Individuals: A Randomized Controlled Crossover Trial
The Effect of Eccentric Cycling on Cerebral and Muscle Tissue Oxygenation in Patients with Pulmonary Hypertension and Healthy Individuals: A Randomized Controlled Crossover Trial Open
Background: Eccentric cycling exercise (ECC) offers a low-metabolic-demand approach to exercise, potentially making it valuable for patients with pulmonary vascular disease (PVD). The aim of this study was to investigate how quadriceps and…
View article: Effect of moderate altitude and nocturnal oxygen therapy on cerebrovascular function in patients with COPD: A randomized, crossover trial at 2048 m
Effect of moderate altitude and nocturnal oxygen therapy on cerebrovascular function in patients with COPD: A randomized, crossover trial at 2048 m Open
We investigated whether nocturnal oxygen therapy improves next‐day cerebrovascular function in lowlanders with chronic obstructive pulmonary disease (COPD) staying at moderate altitude. This randomized, placebo‐controlled single‐blind cros…
View article: Effects of nocturnal periodic breathing on sympathetic nerve activity and ventilatory control at high altitude: a randomised, crossover study
Effects of nocturnal periodic breathing on sympathetic nerve activity and ventilatory control at high altitude: a randomised, crossover study Open
During acute exposure to the hypoxia of high altitude, activation of the peripheral chemoreflex increases sympathetic nerve activity (SNA) and pulmonary ventilation. If exposure extends over several days, SNA and ventilation further increa…
View article: Changes in Retinal Vasculature Phenotype and Choroidal Blood Flow at High Altitude in Healthy Lowlanders
Changes in Retinal Vasculature Phenotype and Choroidal Blood Flow at High Altitude in Healthy Lowlanders Open
Acute high-altitude exposure leads to a decrease of ChBF (partly related to a decrease in blood volume) and an increase in retinal vein diameter and tortuosity. The physiological consequences of these changes on retinal blood flow and reti…
View article: Daith Piercing, a Social Media Hype on Youtube for the Treatment of Migraine? A Systematic Video Analysis
Daith Piercing, a Social Media Hype on Youtube for the Treatment of Migraine? A Systematic Video Analysis Open
Background and Aims Nowadays, the social media video‐sharing website YouTube is globally accessible and used for sharing news and information. It also serves as a tool for migraine sufferers seeking guidance about Daith piercing (DP) as a …
View article: Pulmonary haemodynamics and right heart function during exercise at high versus low altitude in patients with pulmonary vascular disease: a randomised crossover trial
Pulmonary haemodynamics and right heart function during exercise at high versus low altitude in patients with pulmonary vascular disease: a randomised crossover trial Open
Background Patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PAH/CTEPH) may experience physiological stress at high altitude. We investigated pulmonary haemodynamics and right heart function du…
View article: Effect of Eccentric Cycling on Oxygen Uptake and Hemodynamics in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Crossover Trial
Effect of Eccentric Cycling on Oxygen Uptake and Hemodynamics in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Crossover Trial Open
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and contributes significantly to reduced quality of life due to symptoms such as dyspnea and exercise intolerance. Eccentric…
View article: Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules
Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules Open
This study aimed to quantify the effect of two consecutive prolonged, intermittent exposures to high and very high altitudes on oxygen saturation (SpO2) and acute mountain sickness (AMS). For this, healthy lowlanders (N = 21), aged 18-30 y…
View article: Acute effects of 50 mg additive oral sildenafil on invasive exercise haemodynamics in pulmonary vascular disease
Acute effects of 50 mg additive oral sildenafil on invasive exercise haemodynamics in pulmonary vascular disease Open
Background and aims Patients with precapillary pulmonary hypertension (PH) due to pulmonary vascular disease (PVD) have reduced exercise capacity, limiting daily activity and quality of life. Phospodiesterase-5 inhibitors, including silden…
View article: Monitoring sexual hormones in women going to high altitude—a pilot study
Monitoring sexual hormones in women going to high altitude—a pilot study Open
Background The susceptibility to acute mountain sickness (AMS) in relation to sexual hormones in women remains elusive, partly because hormones could not be conveniently measured. We evaluated a novel kit for self-monitoring sexual hormone…
View article: Respiratory acclimatization and psychomotor performance after rapid ascent and during 3 weeks at 3,100 m–A prospective cohort study in healthy individuals
Respiratory acclimatization and psychomotor performance after rapid ascent and during 3 weeks at 3,100 m–A prospective cohort study in healthy individuals Open
Background Acclimatization to high altitudes over several weeks has not been extensively studied. Repeated physiological assessments were performed in healthy lowlanders staying at 3,100 m for 3 weeks. We hypothesized that acute exposure t…
View article: Pulmonary haemodynamics by echocardiography over 3 days of acclimatization in lowlanders with chronic obstructive pulmonary disease travelling to 3100 m of high altitude
Pulmonary haemodynamics by echocardiography over 3 days of acclimatization in lowlanders with chronic obstructive pulmonary disease travelling to 3100 m of high altitude Open
Aims Patients with chronic obstructive pulmonary disease experience an increase in systolic pulmonary artery pressure (sPAP) when exposed to high altitude with an unclear acclimatization. We investigated the effects of acute ascent to 3100…
View article: Peak Eccentric Cycling Exercise and Cardiorespiratory Responses to Normobaric Hypoxia Versus Normobaric Normoxia in Healthy Adults: A Randomized, Controlled Crossover Trial
Peak Eccentric Cycling Exercise and Cardiorespiratory Responses to Normobaric Hypoxia Versus Normobaric Normoxia in Healthy Adults: A Randomized, Controlled Crossover Trial Open
Background/Objectives: Pulmonary rehabilitation clinics are traditionally located at higher altitudes (HAs), where lower PO2 reduces exercise capacity and blood oxygenation. Eccentric cycling exercise (ECC), with its lower cardiorespirator…
View article: Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide
Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide Open
Introduction In patients with chronic obstructive pulmonary disease (COPD), oxygen delivery to the heart may be impaired during travel at altitude. We assessed electrocardiogram (ECG)-derived signs of cardiac ischemia and the effects of pr…
View article: Effect of moderate altitude with and without nocturnal oxygen therapy on the next-day cerebrovascular function in patients with chronic obstructive pulmonary disease – A randomized, cross-over trial at 2048 m
Effect of moderate altitude with and without nocturnal oxygen therapy on the next-day cerebrovascular function in patients with chronic obstructive pulmonary disease – A randomized, cross-over trial at 2048 m Open
Background This study investigated whether nocturnal oxygen therapy (NOT) improves next-day cerebrovascular function in lowlanders with COPD staying at moderate altitude. Methods This randomized, placebo-controlled crossover trial was perf…
View article: Daith piercing, a social media hype on YouTube for the treatment of migraine? A systematic video analysis of quality and reliability
Daith piercing, a social media hype on YouTube for the treatment of migraine? A systematic video analysis of quality and reliability Open
Background Nowadays, social media video-sharing website YouTube is globally accessible and used for sharing news and information. It also serves as a tool for migraine sufferers seeking guidance about Daith piercing as a potential migraine…
View article: A chronological overview of common Chinese medicine treatment methods
A chronological overview of common Chinese medicine treatment methods Open
This overview provides a synopsis of the history and development of Traditional Chinese Medicine (TCM) treatment methods, highlighting its foundational principles and key modalities. While certain concepts are exclusive to TCM, other appli…
View article: Right ventricular strain impairment due to hypoxia in patients with COPD: a post hoc analysis of two randomised controlled trials
Right ventricular strain impairment due to hypoxia in patients with COPD: a post hoc analysis of two randomised controlled trials Open
Background Hypoxic pulmonary vasoconstriction leads to an increase in pulmonary artery pressure (PAP) and potentially right heart failure in healthy individuals and patients with respiratory diseases. Previous studies in patients with chro…
View article: Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules
Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules Open
Objective To quantify the effect of two consecutive prolonged, intermittent exposures to high and very high altitudes on oxygen saturation (SpO 2 ) and acute mountain sickness (AMS). Methods Healthy lowlanders (N=21), aged 18-30y, underwen…
View article: Monitoring sexual hormones in women going to high altitude – a pilot study
Monitoring sexual hormones in women going to high altitude – a pilot study Open
Background The susceptibility to acute mountain sickness (AMS) in relation to sexual hormones in women remains elusive, partly because hormones could not be conveniently measured. We evaluated a novel kit for self-monitoring sexual hormone…
View article: Respiratory acclimatization and psychomotor performance after rapid ascent and during 3 weeks at 3100 m. A prospective cohort study in healthy
Respiratory acclimatization and psychomotor performance after rapid ascent and during 3 weeks at 3100 m. A prospective cohort study in healthy Open
Background The acclimatization to high altitudes over several weeks is not extensively studied. Repeated physiological assessments were performed in healthy lowlanders staying at 3100m for 3 weeks. We hypothesized that over the course of 3…
View article: Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD travelling to 3100 m. Data from a randomized trial of acetazolamide
Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD travelling to 3100 m. Data from a randomized trial of acetazolamide Open
Introduction In patients with chronic obstructive pulmonary disease (COPD), oxygen delivery to the heart may be impaired during altitude travel. We assessed ECG-derived signs of cardiac ischemia, and effects of preventive acetazolamide the…
View article: Acute effect of acetazolamide on exercise haemodynamics in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension: a randomised controlled trial
Acute effect of acetazolamide on exercise haemodynamics in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension: a randomised controlled trial Open
Background The aim of this study was to investigate the acute effect of acetazolamide on pulmonary haemodynamics during exercise in patients with pulmonary vascular disease (PVD). Methods Patients with PVD diagnosed as pulmonary arterial (…