Michael G. Gottschalk
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View article: Contemporary in vivo rodent electroconvulsive therapy (ECT) models in translational depression research: a systematic review
Contemporary in vivo rodent electroconvulsive therapy (ECT) models in translational depression research: a systematic review Open
Electroconvulsive therapy (ECT) has been established as an efficacious and safe treatment for severe and/or treatment-resistant depression. However, despite decades of research, the exact biological signature of the mechanism of action of …
View article: Cerebrospinal fluid proteomics reveals synaptic and immune dysregulation in treatment-resistant schizophrenia
Cerebrospinal fluid proteomics reveals synaptic and immune dysregulation in treatment-resistant schizophrenia Open
IMPORTANCE Treatment-resistant schizophrenia (TRS) affects around one-third of individuals with schizophrenia and is associated with substantial morbidity, mortality, and healthcare burden. Despite its impact, the pathophysiology of TRS re…
View article: The Adult Separation Anxiety Questionnaire (ASA-27): reliability of the German translation, factor structure, and concurrent validity with anxiety sensitivity and agoraphobic cognition
The Adult Separation Anxiety Questionnaire (ASA-27): reliability of the German translation, factor structure, and concurrent validity with anxiety sensitivity and agoraphobic cognition Open
Background Separation anxiety disorder (SEPAD) is characterized by pronounced fear or anxiety concerning separation from attachment figures. Despite its high lifetime prevalence, adult SEPAD often remains undetected due to a lack of diagno…
View article: Not so different after all: a systematic review of rodent electroconvulsive therapy (ECT) models in translational chronic stress and depression research
Not so different after all: a systematic review of rodent electroconvulsive therapy (ECT) models in translational chronic stress and depression research Open
Electroconvulsive therapy (ECT) has been established as an efficacious and safe treatment for severe and/or treatment-resistant depression. However, despite decades of research, the exact biological signature of the mechanism of action of …
View article: Epigenetics Underlying Susceptibility and Resilience Relating to Daily Life Stress, Work Stress, and Socioeconomic Status
Epigenetics Underlying Susceptibility and Resilience Relating to Daily Life Stress, Work Stress, and Socioeconomic Status Open
Susceptibility and resilience to mental disorders result from a complex choreography of gene-environment interactions with epigenetics at the intersection of external psychological stressors and internal biological systems. Increasing awar…
View article: Supplementary Material for: Oxytocin Receptor Gene DNA Methylation: A Biomarker of Treatment Response in Obsessive-Compulsive Disorder?
Supplementary Material for: Oxytocin Receptor Gene DNA Methylation: A Biomarker of Treatment Response in Obsessive-Compulsive Disorder? Open
Introduction: Obsessive-compulsive disorder (OCD) is associated with high chronicity and treatment resistance, indicating the need for early therapy response markers enabling fast and personalized treatment adaptations. Altho…
View article: Temporal proteomic profiling of postnatal human cortical development
Temporal proteomic profiling of postnatal human cortical development Open
Healthy cortical development depends on precise regulation of transcription and translation. However, the dynamics of how proteins are expressed, function and interact across postnatal human cortical development remain poorly understood. W…
View article: Cerebrospinal Fluid Concentrations of Neuronal Proteins Are Reduced in Primary Angiitis of the Central Nervous System
Cerebrospinal Fluid Concentrations of Neuronal Proteins Are Reduced in Primary Angiitis of the Central Nervous System Open
Primary angiitis of the central nervous system (PACNS) is a rare autoimmune vasculitis limited to the CNS often causing substantial disability. Understanding of this disease is impaired by the lack of available biomaterial. Here, we collec…
View article: Fluoxetine, not donepezil, reverses anhedonia, cognitive dysfunctions and hippocampal proteome changes during repeated social defeat exposure
Fluoxetine, not donepezil, reverses anhedonia, cognitive dysfunctions and hippocampal proteome changes during repeated social defeat exposure Open
View article: Temporal proteomic profiling of postnatal human cortical development
Temporal proteomic profiling of postnatal human cortical development Open
Healthy cortical development depends on precise regulation of transcription and translation. However, the dynamics of how proteins are expressed, function and interact across postnatal human cortical development remain poorly understood. W…
View article: Genetics of generalized anxiety disorder and related traits
Genetics of generalized anxiety disorder and related traits Open
This review serves as a systematic guide to the genetics of generalized anxiety disorder (GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry fear of uncertainty, and neuroticism. We inspect clinical gen…
View article: A novel methodology to evaluate the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology
A novel methodology to evaluate the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology Open
Rodent models of schizophrenia (SCZ) are indispensable when screening for novel treatments, but quantifying their translational relevance with the underlying human pathophysiology has proved difficult. A novel systems methodology (shown in…
View article: Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: A proteomic systems approach
Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: A proteomic systems approach Open
OBJECTIVES: Rodent models of major depressive disorder (MDD) are indispensable when screening for novel treatments, but assessing their translational relevance with human brain pathology has proved difficult. METHODS: Using a novel systems…
View article: Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: A proteomic systems approach
Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: A proteomic systems approach Open
Objectives: Rodent models of major depressive disorder (MDD) are indispensable when screening for novel treatments, but assessing their translational relevance with human brain pathology has proved difficult. Methods: Using a…
View article: Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: a proteomic systems approach
Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: a proteomic systems approach Open
Objectives: Rodent models of major depressive disorder (MDD) are indispensable when screening for novel treatments, but assessing their translational relevance with human brain pathology has proved difficult. Methods: Using a…
View article: Proteomic Enrichment Analysis of Psychotic and Affective Disorders Reveals Common Signatures in Presynaptic Glutamatergic Signaling and Energy Metabolism
Proteomic Enrichment Analysis of Psychotic and Affective Disorders Reveals Common Signatures in Presynaptic Glutamatergic Signaling and Energy Metabolism Open
These findings support recent investigations, which have focused on the therapeutic potential of glutamatergic modulation in psychotic and affective disorders. We suggest a disease model in which disturbances of the glutamatergic system an…
View article: Central and peripheral changes underlying susceptibility and resistance to social defeat stress – A proteomic profiling study
Central and peripheral changes underlying susceptibility and resistance to social defeat stress – A proteomic profiling study Open