Michael G. Monaghan
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View article: 63 Iron deficiency in ambulatory heart failure patients: evaluating the role of hypophosphataemia risk in selecting intravenous iron therapy
63 Iron deficiency in ambulatory heart failure patients: evaluating the role of hypophosphataemia risk in selecting intravenous iron therapy Open
View article: Biofabrication of an Ovine Intervertebral Disc Model by Combining a Polycaprolactone Frame with a Bioprinted Alginate Hydrogel
Biofabrication of an Ovine Intervertebral Disc Model by Combining a Polycaprolactone Frame with a Bioprinted Alginate Hydrogel Open
The intervertebral disc (IVD) primarily comprises an outer ring of collagen fibers (annulus fibrosus, AF), which encases a soft, gelatinous core (nucleus pulposus, NP). Existing in vitro models have failed to integrate these two tissues ef…
View article: BIOFABRICATION OF AN OVINE INTERVERTEBRAL DISC MODEL BY COMBINING A POLYCAPROLACTONE FRAME WITH A BIOPRINTED ALGINATE HYDROGEL
BIOFABRICATION OF AN OVINE INTERVERTEBRAL DISC MODEL BY COMBINING A POLYCAPROLACTONE FRAME WITH A BIOPRINTED ALGINATE HYDROGEL Open
The intervertebral disc (IVD) primarily comprises an outer ring of collagen fibers (annulus fibrosus, AF), which encases a soft, gelatinous core (nucleus pulposus, NP). Existing in vitro models have failed to integrate these two tissues ef…
View article: Electrically Conductive Injectable Silk/<scp>PEDOT</scp>: <scp>PSS</scp> Hydrogel for Enhanced Neural Network Formation
Electrically Conductive Injectable Silk/<span>PEDOT</span>: <span>PSS</span> Hydrogel for Enhanced Neural Network Formation Open
With no effective treatments for functional recovery after injury, spinal cord injury (SCI) remains one of the unresolved healthcare challenges. Human induced pluripotent stem cell (hiPSC) transplantation is a versatile patient‐specific re…
View article: From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair
From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair Open
View article: Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms
Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms Open
Cardiovascular disease stands as the leading cause of death globally, claiming approximately 19million lives in 2020. On the contrary, the development of cardiovascular drugs is experiencing a decline, largely due to the bottleneck in unde…
View article: Parallelizing Adaptive Reliability Analysis Through Penalizing the Learning Function
Parallelizing Adaptive Reliability Analysis Through Penalizing the Learning Function Open
View article: Staphylococcus aureus induced trained immunity in macrophages confers heterologous protection against gram-negative bacterial infection
Staphylococcus aureus induced trained immunity in macrophages confers heterologous protection against gram-negative bacterial infection Open
Staphylococcus aureus can induce trained immunity in murine macrophages offering protection against repeat exposure during S. aureus skin infection. Here we demonstrate that S. aureus exposure can result in non-specifi…
View article: Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset
Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset Open
This study performed an in-depth investigation into the myeloid cellular landscape in the synovium of patients with rheumatoid arthritis (RA), “individuals at risk” of RA, and healthy controls (HC). Flow cytometric analysis demonstrated th…
View article: Electrostimulation via a 3D-printed, biomimetic, neurotrophic, electroconductive scaffold for the promotion of axonal regrowth after spinal cord injury
Electrostimulation via a 3D-printed, biomimetic, neurotrophic, electroconductive scaffold for the promotion of axonal regrowth after spinal cord injury Open
View article: Melt electrowriting of poly(ϵ-caprolactone)—poly(ethylene glycol) backbone polymer blend scaffolds with improved hydrophilicity and functionality
Melt electrowriting of poly(ϵ-caprolactone)—poly(ethylene glycol) backbone polymer blend scaffolds with improved hydrophilicity and functionality Open
Melt electrowriting (MEW) is an additive manufacturing technique that harnesses electro-hydrodynamic phenomena to produce 3D-printed fibres with diameters on the scale of 10s of microns. The ability to print at this small scale provides op…
View article: Impact of the Reduction Time-Dependent Electrical Conductivity of Graphene Nanoplatelet-Coated Aligned <i>Bombyx mori</i> Silk Scaffolds on Electrically Stimulated Axonal Growth
Impact of the Reduction Time-Dependent Electrical Conductivity of Graphene Nanoplatelet-Coated Aligned <i>Bombyx mori</i> Silk Scaffolds on Electrically Stimulated Axonal Growth Open
Graphene-based nanomaterials, renowned for their outstanding electrical conductivity, have been extensively studied as electroconductive biomaterials (ECBs) for electrically stimulated tissue regeneration. However, using eco-friendly reduc…
View article: 2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified
2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified Open
Background Human mesenchymal stem cells (hMSCs) utilize discrete biosynthetic pathways to self-renew and differentiate into specific cell lineages, with undifferentiated hMSCs harbouring reliance on glycolysis and hMSCs differentiating tow…
View article: Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment
Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment Open
Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading to tissue regeneratio…
View article: Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding
Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding Open
Organoid models have been used to address important questions in developmental and cancer biology, tissue repair, advanced modelling of disease and therapies, among other bioengineering applications. Such 3D microenvironmental models can i…
View article: Time-Dependent Anabolic Response of hMSC-Derived Cartilage Grafts to Hydrostatic Pressure
Time-Dependent Anabolic Response of hMSC-Derived Cartilage Grafts to Hydrostatic Pressure Open
It is generally accepted that the application of hydrostatic pressure (HP) is beneficial for MSC chondrogenesis. There is, however, evidence to suggest that the timing of application might determine its impact on cell fate and tissue devel…
View article: A Workflow to Produce a Low-Cost In Vitro Platform for the Electric-Field Pacing of Cellularised 3D Porous Scaffolds
A Workflow to Produce a Low-Cost In Vitro Platform for the Electric-Field Pacing of Cellularised 3D Porous Scaffolds Open
Endogenous electrically mediated signaling is a key feature of most native tissues, the most notable examples being the nervous and the cardiac systems. Biomedical engineering often aims to harness and drive such activity in vitro, in bior…
View article: MXene functionalized collagen biomaterials for cardiac tissue engineering driving iPSC-derived cardiomyocyte maturation
MXene functionalized collagen biomaterials for cardiac tissue engineering driving iPSC-derived cardiomyocyte maturation Open
View article: An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis
An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis Open
Mechanical stimulation can modulate the chondrogenic differentiation of stem/progenitor cells and potentially benefit tissue engineering (TE) of functional articular cartilage (AC). Mechanical cues like hydrostatic pressure (HP) are often …
View article: 2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified
2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified Open
I. Background : Human mesenchymal stem cells (hMSCs) fuel discrete biosynthetic pathways to multiply and differentiate into specific cell lineages; with undifferentiated hMSCs showing reliance on glycolytic respiration. hMSCs differentiati…
View article: Melt electrowriting of a biocompatible photo‐crosslinkable poly(D,L‐lactic acid)/poly(ε‐caprolactone)‐based material with tunable mechanical and functionalization properties
Melt electrowriting of a biocompatible photo‐crosslinkable poly(D,L‐lactic acid)/poly(ε‐caprolactone)‐based material with tunable mechanical and functionalization properties Open
The use of polymeric biomaterials to create tissue scaffolds using additive manufacturing techniques is a well‐established practice, owing to the incredible rapidity and complexity in design that modern 3D printing methods can provide. One…
View article: Macrophage metabolic profile is altered by hydroxyapatite particle size
Macrophage metabolic profile is altered by hydroxyapatite particle size Open
Since the recent observation that immune cells undergo metabolic reprogramming upon activation, there has been immense research in this area to not only understand the basis of such changes, but also to exploit metabolic rewiring for thera…
View article: 2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified
2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified Open
Human mesenchymal stem cells (hMSCs) fuel discrete biosynthetic pathways to multiply and differentiate into specific cell lineages; with undifferentiated hMSCs showing reliance on glycolysis. hMSCs differentiating towards an osteogenic phe…
View article: Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis
Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis Open
View article: A guide to the manufacture of sustainable, ready to use in vitro platforms for the electric-field pacing of cellularised 3D porous scaffolds
A guide to the manufacture of sustainable, ready to use in vitro platforms for the electric-field pacing of cellularised 3D porous scaffolds Open
Electrical activity is a key feature of most native tissues, with the most notable examples being the nervous and the cardiac systems. Modern medicine has moved towards the mimicking and regenerations of such systems both with in vitro mod…
View article: A preclinical model of cutaneous melanoma based on reconstructed human epidermis
A preclinical model of cutaneous melanoma based on reconstructed human epidermis Open
Malignant melanoma is among the tumor entities with the highest increase of incidence worldwide. To elucidate melanoma progression and develop new effective therapies, rodent models are commonly used. While these do not adequately reflect …
View article: Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning
Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning Open
In this study, we utilise fluorescence lifetime imaging of NAD(P)H-based cellular autofluorescence as a non-invasive modality to classify two contrasting states of human macrophages by proxy of their governing metabolic state. Macrophages …
View article: Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis.
Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis. Open
BackgroundThoroughbred racehorse performance is largely influenced by a major quantitative trait locus at the myostatin ( MSTN ) gene which determines aptitude for certain race distances due to a promoter region insertion mutation influenc…
View article: Hydrophilic, conductive and flexible piezoresistive PEDOT:PSS 3D sensors with tunable microarchitecture and crosslinked using a PEGylated crosslinker
Hydrophilic, conductive and flexible piezoresistive PEDOT:PSS 3D sensors with tunable microarchitecture and crosslinked using a PEGylated crosslinker Open
Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) is an emerging biomaterial that – due to its stability and conductivity - has been adopted for diverse biomedical technologies, such as biosensors, coatings for electrode…
View article: OP0013 LOSS OF SYNOVIAL TISSUE MACROPHAGE HOMEOSTASIS PRECEDES RHEUMATOID ARTHRITIS CLINICAL ONSET
OP0013 LOSS OF SYNOVIAL TISSUE MACROPHAGE HOMEOSTASIS PRECEDES RHEUMATOID ARTHRITIS CLINICAL ONSET Open