Michael G. Sovic
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View article: Persistence of SARS-CoV-2 Alpha Variant in White-Tailed Deer, Ohio, USA
Persistence of SARS-CoV-2 Alpha Variant in White-Tailed Deer, Ohio, USA Open
Free-ranging white-tailed deer (WTD) are highly susceptible to the SARS-CoV-2 virus. Through an opportunistic sampling of WTD in northeast Ohio, USA, during January-March 2023, we identified 6 SARS-CoV-2 lineages from 36 sequences using th…
View article: Clinical and Genomic Characteristics of Candida auris in Central Ohio: An Insight into Epidemiological Surveillance
Clinical and Genomic Characteristics of Candida auris in Central Ohio: An Insight into Epidemiological Surveillance Open
Background: Candida auris is an emerging threat to hospitalized patients and invasive disease is associated with high mortality. This study describes clinical and microbiological characteristics of nine patients identified with C. auris at…
View article: Use of Whole Genome Sequencing for Investigation of Potential Hospital-Acquired Vancomycin Resistant Enterococcus
Use of Whole Genome Sequencing for Investigation of Potential Hospital-Acquired Vancomycin Resistant Enterococcus Open
Background: Whole genome sequencing (WGS) is a relatively new method for analyzing outbreaks and modes of transmission, particularly for multidrug resistant bacteria. This study sought to investigate clusters of patients with genetically r…
View article: Identification of SARS-CoV-2 variants in indoor dust
Identification of SARS-CoV-2 variants in indoor dust Open
Environmental surveillance of pathogens underlying infectious disease is critical to ensure public health. Recent efforts to track SARS-CoV-2 have utilized wastewater sampling to infer community trends in viral abundance and variant compos…
View article: Hypermethylation and small RNA expression are associated with increased age in almond (Prunus dulcis [Mill.] D.A. Webb) accessions
Hypermethylation and small RNA expression are associated with increased age in almond (Prunus dulcis [Mill.] D.A. Webb) accessions Open
The focus of this study is to profile changes in DNA methylation and small RNA expression occurring with increased age in almond breeding germplasm to identify possible biomarkers of age that can be used to assess the potential of individu…
View article: Ohio Coronavirus Wastewater Monitoring Network: Implementation of Statewide Monitoring for Protecting Public Health
Ohio Coronavirus Wastewater Monitoring Network: Implementation of Statewide Monitoring for Protecting Public Health Open
Context: Prior to the COVID-19 pandemic, wastewater influent monitoring for tracking disease burden in sewered communities was not performed in Ohio, and this field was only on the periphery of the state academic research community. Progra…
View article: Whole-genome sequencing of carbapenem-resistant Enterobacterales isolates and evaluation of hospital-acquired infections
Whole-genome sequencing of carbapenem-resistant Enterobacterales isolates and evaluation of hospital-acquired infections Open
Background: Multidrug-resistant organisms (MDROs) are increasingly implicated in nosocomial outbreaks worldwide. We evaluated whole-genome sequencing (WGS) as an adjunctive epidemiological tool to identify infection clusters and MDRO trans…
View article: Genetic mutations linked to field‐evolved Cry1Fa-resistance in the European corn borer, Ostrinia nubilalis
Genetic mutations linked to field‐evolved Cry1Fa-resistance in the European corn borer, Ostrinia nubilalis Open
View article: MixviR: an R Package for Exploring Variation Associated with Genomic Sequence Data from Environmental SARS-CoV-2 and Other Mixed Microbial Samples
MixviR: an R Package for Exploring Variation Associated with Genomic Sequence Data from Environmental SARS-CoV-2 and Other Mixed Microbial Samples Open
High-throughput sequencing technologies hold great potential for contributing to genomic-based surveillance of microbial diversity from environmental samples. However, the size of the data sets, along with the potential for environmental s…
View article: Mechanisms of Pine Disease Susceptibility Under Experimental Climate Change
Mechanisms of Pine Disease Susceptibility Under Experimental Climate Change Open
Climate change (CC) conditions projected for many temperate areas of the world, expressed by way of excessive temperatures and low water availability, will impact forest health directly by means of abiotic stress but also by predisposing t…
View article: The Role of Egg Yolk in Modulating the Virulence of Salmonella Enterica Serovar Enteritidis
The Role of Egg Yolk in Modulating the Virulence of Salmonella Enterica Serovar Enteritidis Open
Contribution of food vehicles to pathogenicity of disease-causing microorganisms is an important but overlooked research field. The current study was initiated to reveal the relationship between virulence of Salmonella enterica serovar Ent…
View article: Frequency, composition and mobility of <i>Escherichia coli</i> ‐derived transposable elements in holdings of plasmid repositories
Frequency, composition and mobility of <i>Escherichia coli</i> ‐derived transposable elements in holdings of plasmid repositories Open
Summary By providing the scientific community with uniform and standardized resources of consistent quality, plasmid repositories play an important role in enabling scientific reproducibility. Plasmids containing insertion sequence element…
View article: Dietary omega-3 fatty acid intake impacts peripheral blood DNA methylation -anti-inflammatory effects and individual variability in a pilot study
Dietary omega-3 fatty acid intake impacts peripheral blood DNA methylation -anti-inflammatory effects and individual variability in a pilot study Open
View article: Hypermethylation and small RNA expression are associated with increased age in almond (<i>Prunus dulcis</i>[Mill.] D.A. Webb) accessions
Hypermethylation and small RNA expression are associated with increased age in almond (<i>Prunus dulcis</i>[Mill.] D.A. Webb) accessions Open
Summary The focus of this study is to profile changes in DNA methylation and small RNA expression occurring with increased age in almond breeding germplasm to identify possible biomarkers of age that can be used to assess the potential of …
View article: Peripheral Blood DNA Methylation Changes after Omega-3 Fatty Acid Treatment Indicate Anti-inflammatory Effects and Individual Variability
Peripheral Blood DNA Methylation Changes after Omega-3 Fatty Acid Treatment Indicate Anti-inflammatory Effects and Individual Variability Open
Background Omega-3 or n-3 polyunsaturated fatty acids (PUFAs) are widely studied for health benefits based on potential anti-inflammatory effects. However, the factors involved in mediating the anti-inflammatory responses to n-3 PUFAs are …
View article: CLEAR: coverage-based limiting-cell experiment analysis for RNA-seq
CLEAR: coverage-based limiting-cell experiment analysis for RNA-seq Open
View article: Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor
Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor Open
No approved therapy exists for cancer-associated cachexia. The colon-26 mouse model of cancer cachexia mimics recent late-stage clinical failures of anabolic anti-cachexia therapy and was unresponsive to anabolic doses of diverse androgens…
View article: Genetic signatures of small effective population sizes and demographic declines in an endangered rattlesnake, <i>Sistrurus catenatus</i>
Genetic signatures of small effective population sizes and demographic declines in an endangered rattlesnake, <i>Sistrurus catenatus</i> Open
Endangered species that exist in small isolated populations are at elevated risk of losing adaptive variation due to genetic drift. Analyses that estimate short‐term effective population sizes, characterize historical demographic processes…
View article: gwasurvivr: an R package for genome-wide survival analysis
gwasurvivr: an R package for genome-wide survival analysis Open
Summary To address the limited software options for performing survival analyses with millions of SNPs, we developed gwasurvivr, an R/Bioconductor package with a simple interface for conducting genome-wide survival analyses using VCF (outp…
View article: CLEAR: Coverage-based Limiting-cell Experiment Analysis for RNA-seq
CLEAR: Coverage-based Limiting-cell Experiment Analysis for RNA-seq Open
Direct cDNA preamplification protocols developed for single-cell RNA-seq have enabled transcriptome profiling of precious clinical samples and rare cells without sample pooling or RNA extraction. Currently, there is no algorithm optimized …
View article: gwasurvivr: an R package for genome wide survival analysis
gwasurvivr: an R package for genome wide survival analysis Open
Summary To address the limited software options for performing survival analyses with millions of SNPs, we developed gwasurvivr, an R/Bioconductor package with a simple interface for conducting genome wide survival analyses using VCF (outp…
View article: Recent lineage diversification in a venomous snake through dispersal across the Amazon River
Recent lineage diversification in a venomous snake through dispersal across the Amazon River Open
Identifying the evolutionary and ecological mechanisms that drive lineage diversification in the species-rich tropics is of broad interest to evolutionary biologists. Here, we use phylogeographical and demographic analyses of genome-scale …
View article: Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42
Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42 Open
Purpose The common colon-26 mouse (C-26) model of experimental cachexia mimics recent late stage clinical failures of anabolic anti-cachexia therapy, and does not respond to the anabolic selective androgen receptor modulator (SARM) GTx-024…
View article: <i>assign<scp>POP</scp>:</i> An <scp>r</scp> package for population assignment using genetic, non‐genetic, or integrated data in a machine‐learning framework
<i>assign<span>POP</span>:</i> An <span>r</span> package for population assignment using genetic, non‐genetic, or integrated data in a machine‐learning framework Open
The use of biomarkers (e.g., genetic, microchemical and morphometric characteristics) to discriminate among and assign individuals to a population can benefit species conservation and management by facilitating our ability to understand po…
View article: Origin of a cryptic lineage in a threatened reptile through isolation and historical hybridization
Origin of a cryptic lineage in a threatened reptile through isolation and historical hybridization Open
View article: Within‐group relatedness is correlated with colony‐level social structure and reproductive sharing in a social fish
Within‐group relatedness is correlated with colony‐level social structure and reproductive sharing in a social fish Open
In group‐living species, the degree of relatedness among group members often governs the extent of reproductive sharing, cooperation and conflict within a group. Kinship among group members can be shaped by the presence and location of nei…
View article: Hybrid origin of European Vipers (Vipera magnifica and Vipera orlovi) from the Caucasus determined using genomic scale DNA markers
Hybrid origin of European Vipers (Vipera magnifica and Vipera orlovi) from the Caucasus determined using genomic scale DNA markers Open
View article: Genetic diversity in migratory bats: Results from RADseq data for three tree bat species at an Ohio windfarm
Genetic diversity in migratory bats: Results from RADseq data for three tree bat species at an Ohio windfarm Open
Genetic analyses can identify the scale at which wildlife species are impacted by human activities, and provide demographic information useful for management. Here, we use thousands of nuclear DNA genetic loci to assess whether genetic str…
View article: Peer Review #2 of "Genetic diversity in migratory bats: Results from RADseq data for three tree bat species at an Ohio windfarm (v0.1)"
Peer Review #2 of "Genetic diversity in migratory bats: Results from RADseq data for three tree bat species at an Ohio windfarm (v0.1)" Open
Genetic analyses can identify the scale at which wildlife species are impacted by human activities, and provide demographic information useful for management.Here, we use thousands of nuclear DNA genetic loci to assess whether genetic stru…
View article: Peer Review #1 of "Genetic diversity in migratory bats: Results from RADseq data for three tree bat species at an Ohio windfarm (v0.1)"
Peer Review #1 of "Genetic diversity in migratory bats: Results from RADseq data for three tree bat species at an Ohio windfarm (v0.1)" Open
Genetic analyses can identify the scale at which wildlife species are impacted by human activities, and provide demographic information useful for management.Here, we use thousands of nuclear DNA genetic loci to assess whether genetic stru…