Michael G.B. Hayes
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View article: Retraction Notice to: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers
Retraction Notice to: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers Open
View article: Data presented in "Short tandem repeats bind transcription factors to tune eukaryotic gene expression"
Data presented in "Short tandem repeats bind transcription factors to tune eukaryotic gene expression" Open
Here you can find the data supporting the conclusions in "Short tandem repeats bind transcription factors to tune eukaryotic gene expression." The accompanying code repository can be found at https://doi.org/10.5281/zenodo.8161422.
View article: Data presented in "Short tandem repeats bind transcription factors to tune eukaryotic gene expression"
Data presented in "Short tandem repeats bind transcription factors to tune eukaryotic gene expression" Open
Here you can find the data supporting the conclusions in "Short tandem repeats bind transcription factors to tune eukaryotic gene expression." The accompanying code repository can be found at https://doi.org/10.5281/zenodo.8161422.
View article: DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal
DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal Open
View article: The epigenetic modifier DOT1L regulates gene regulatory networks necessary for cardiac patterning and cardiomyocyte cell cycle withdrawal
The epigenetic modifier DOT1L regulates gene regulatory networks necessary for cardiac patterning and cardiomyocyte cell cycle withdrawal Open
Mechanisms by which specific histone modifications regulate distinct gene regulatory networks remain little understood. We investigated how H3K79me2, a modification catalyzed by DOT1L and previously considered a general transcriptional act…
View article: Short tandem repeats bind transcription factors to tune eukaryotic gene expression
Short tandem repeats bind transcription factors to tune eukaryotic gene expression Open
Short tandem repeats (STRs) are enriched in eukaryotic cis -regulatory elements and their polymorphisms alter gene expression, yet how they regulate transcription remains unknown. We find that STRs can modulate transcription factor (TF)-DN…
View article: Automation enables high-throughput and reproducible single-cell transcriptomics library preparation
Automation enables high-throughput and reproducible single-cell transcriptomics library preparation Open
View article: Chromosome 10q26–driven age-related macular degeneration is associated with reduced levels of <i>HTRA1</i> in human retinal pigment epithelium
Chromosome 10q26–driven age-related macular degeneration is associated with reduced levels of <i>HTRA1</i> in human retinal pigment epithelium Open
Significance The chromosome 10q26 locus is the genetic region most strongly associated with elevated risk of age-related macular degeneration (AMD), but the underlying genetic defects initiating disease are unresolved. Using human-derived …
View article: RETRACTED: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers
RETRACTED: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers Open
View article: Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome
Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome Open
Current technologies used to generate CRISPR/Cas gene perturbation reagents are labor intense and require multiple ligation and cloning steps. Furthermore, increasing gRNA sequence diversity negatively affects gRNA distribution, leading to…
View article: WITHDRAWN: Genomic decoding of neuronal depolarization by stimulus-specific NPAS4 heterodimers
WITHDRAWN: Genomic decoding of neuronal depolarization by stimulus-specific NPAS4 heterodimers Open
WITHDRAWAL STATEMENT This manuscript has been withdrawn after a formal request from The Office of Research Integrity of the U.S. Department of Health & Human Services, with the support of the corresponding author, Brenda Bloodgood. More in…
View article: Author response: Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome
Author response: Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Current technologies used to generate CRIS…
View article: Transcription Elongation Can Affect Genome 3D Structure
Transcription Elongation Can Affect Genome 3D Structure Open