Michael Gerlt
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View article: Acoustofluidic Chromatography for Extracellular Vesicle Enrichment from 4 μL Blood Plasma Samples
Acoustofluidic Chromatography for Extracellular Vesicle Enrichment from 4 μL Blood Plasma Samples Open
We present a novel acoustofluidic chromatography platform for high-throughput nanoparticle trapping and enrichment, with a focus on extracellular vesicles (EVs) from blood plasma. The system features a packed bed of polystyrene beads insid…
View article: Microfluidics‐Driven Manufacturing and Multiscale Analytical Characterization of Nanoparticle‐Vesicle Hybrids
Microfluidics‐Driven Manufacturing and Multiscale Analytical Characterization of Nanoparticle‐Vesicle Hybrids Open
Coating synthetic nanoparticles (NPs) with lipid membranes is a promising approach to enhance the performance of nanomaterials in various biological applications, including therapeutic delivery to target organs. Current methods for achievi…
View article: OxyHbMeter—a novel bedside medical device for monitoring cell-free hemoglobin in the cerebrospinal fluid—proof of principle
OxyHbMeter—a novel bedside medical device for monitoring cell-free hemoglobin in the cerebrospinal fluid—proof of principle Open
Delayed cerebral ischemia (DCI) occurs in up to one third of patients suffering from aneurysmal subarachnoid hemorrhage (aSAH). Untreated, it leads to secondary cerebral infarctions and is frequently associated with death or severe disabil…
View article: High Aspect Ratio Nanoscale Pores through BCP-Based Metal Oxide Masks and Advanced Dry Etching
High Aspect Ratio Nanoscale Pores through BCP-Based Metal Oxide Masks and Advanced Dry Etching Open
The reliable and regular modification of the surface properties of substrates plays a crucial role in material research and the development of functional surfaces. A key aspect of this is the development of the surface pores and topographi…
View article: Focusing of Micrometer-Sized Metal Particles Enabled by Reduced Acoustic Streaming via Acoustic Forces in a Round Glass Capillary
Focusing of Micrometer-Sized Metal Particles Enabled by Reduced Acoustic Streaming via Acoustic Forces in a Round Glass Capillary Open
Two-dimensional (2D) metal-particle focusing is an essential task for various fabrication processes. While acoustofluidic devices can manipulate particles in two-dimensions, the production of these devices often demands a cleanroom environ…
View article: Optical feedback control loop for the precise and robust acoustic focusing of cells, micro- and nanoparticles
Optical feedback control loop for the precise and robust acoustic focusing of cells, micro- and nanoparticles Open
Replacing a human operator by an open source optical feedback control loop for acoustofluidic focusing of biological cells ( e.g. cancer cells in different resonance modes), micro- and nanometer particles results in an improved device perf…
View article: Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications
Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications Open
Acoustically excited microstructures have demonstrated significant potential for small-scale biomedical applications by overcoming major microfluidic limitations. Recently, the application of oscillating microbubbles has demonstrated their…
View article: Acoustic Metal Particle Focusing in a Round Glass Capillary
Acoustic Metal Particle Focusing in a Round Glass Capillary Open
Two-dimensional metal particle focusing is an essential task for various fabrication processes. While acoustofluidic devices can manipulate particles in two dimensions, the production of these devices often demands a cleanroom environment.…
View article: Acoustofluidic Medium Exchange for Preparation of Electrocompetent Bacteria Using Channel Wall Trapping
Acoustofluidic Medium Exchange for Preparation of Electrocompetent Bacteria Using Channel Wall Trapping Open
Transformation, i.e. reprogramming of bacteria by delivering exogenous genetic material (such as DNA) into the cytoplasm, is a key process in molecular engineering and modern biotechnology in general. Transformation is often performed by e…
View article: Acoustofluidic Medium Exchange for Preparation of Electrocompetent Bacteria Using Channel Wall Trapping
Acoustofluidic Medium Exchange for Preparation of Electrocompetent Bacteria Using Channel Wall Trapping Open
Transformation, i.e. reprogramming of bacteria by delivering exogenous genetic material (such as DNA) into the cytoplasm, is a key process in molecular engineering and modern biotechnology in general. Transformation is often performed by e…
View article: Reduced Etch Lag and High Aspect Ratios by Deep Reactive Ion Etching (DRIE)
Reduced Etch Lag and High Aspect Ratios by Deep Reactive Ion Etching (DRIE) Open
Deep reactive ion etching (DRIE) with the Bosch process is one of the key procedures used to manufacture micron-sized structures for MEMS and microfluidic applications in silicon and, hence, of increasing importance for miniaturisation in …
View article: Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications
Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications Open
Acoustically excited microstructures have demonstrated significant potential for small scale biomedical applications by overcoming major microfluidic limitations. Recently, the application of oscillating microbubbles has demonstrated their…
View article: Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications
Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications Open
Acoustically excited microstructures have demonstrated significant potential for small scale biomedical applications by overcoming major microfluidic limitations. Recently, the application of oscillating microbubbles has demonstrated their…
View article: Acoustofluidic medium exchange for preparation of electrocompetent bacteria using channel wall trapping
Acoustofluidic medium exchange for preparation of electrocompetent bacteria using channel wall trapping Open
Comprehensive integration of process steps into a miniaturised version of synthetic biology workflows remains a crucial task in automating the design of biosystems. We present an acoustofluidic chip, capable of automated medium exchange of…
View article: Manipulation of single cells inside nanoliter water droplets using acoustic forces
Manipulation of single cells inside nanoliter water droplets using acoustic forces Open
Droplet microfluidics enables high-throughput screening of single cells and is particularly valuable for applications, where the secreted compounds are analyzed. Typically, optical methods are employed for analysis, which are limited in th…
View article: Spray deposition of polymeric thin-films for the inline encapsulation of organic photodiodes
Spray deposition of polymeric thin-films for the inline encapsulation of organic photodiodes Open
In this contribution, we report the modifications incurring in the electro-optical characteristics of Organic Photodiodes exposed to ambient conditions on rigid and flexible substrates. Once the degradation of the devices is assessed and t…