Michael Getman
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View article: BMI1 regulates human erythroid self-renewal through both gene repression and gene activation
BMI1 regulates human erythroid self-renewal through both gene repression and gene activation Open
The limited proliferative capacity of erythroid precursors is a major obstacle to generate sufficient in vitro-derived red blood cells for clinical purposes. While BMI1, a Polycomb Repressive Complex 1 member, is both necessary and suffici…
View article: The Condensin II Complex Regulates the Expression of Essential Gene Expression Programs During Erythropoiesis
The Condensin II Complex Regulates the Expression of Essential Gene Expression Programs During Erythropoiesis Open
Erythropoiesis is characterized by dramatic changes in gene expression in the context of a cell that is rapidly proliferating while simultaneously condensing its nucleus in anticipation of enucleation. The mechanisms that maintain high lev…
View article: HEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells
HEXIM1 Regulates Early Erythropoiesis and Participates in Multiple Complexes in Erythroid Cells Open
In a healthy adult, steady-state erythropoiesis generates a remarkable ~2.5 million mature RBCs every second. The process of erythropoiesis can be divided into distinct phases: early erythropoiesis- the commitment of multi-lineage progenit…
View article: BMI1 regulates human erythroid self-renewal through both gene repression and gene activation
BMI1 regulates human erythroid self-renewal through both gene repression and gene activation Open
The limited proliferative capacity of erythroid precursors is a major obstacle to generate sufficient numbers of in vitro-derived red blood cells (RBC) for clinical purposes. We and others have determined that BMI1, a member of the polycom…
View article: HEXIM1 is an essential transcription regulator during human erythropoiesis
HEXIM1 is an essential transcription regulator during human erythropoiesis Open
Regulation of RNA polymerase II (RNAPII) activity is an essential process that governs gene expression; however, its contribution to the fundamental process of erythropoiesis remains unclear. hexamethylene bis-acetamide inducible 1 (HEXIM1…
View article: Regulation of RNA polymerase II activity is essential for terminal erythroid maturation
Regulation of RNA polymerase II activity is essential for terminal erythroid maturation Open
The terminal maturation of human erythroblasts requires significant changes in gene expression in the context of dramatic nuclear condensation. Defects in this process are associated with inherited anemias and myelodysplastic syndromes. Th…
View article: Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function
Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function Open
Stratification of enhancers by signal strength in ChIP-seq assays has resulted in the establishment of super-enhancers as a widespread and useful tool for identifying cell type-specific, highly expressed genes and associated pathways. We e…
View article: The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation
The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation Open
Background SETD8 is the sole methyltransferase capable of mono-methylating histone H4, lysine 20. SETD8 and H4K20me1 play a role in a number of essential biologic processes, including cell cycle progression, establishment of higher order c…
View article: Hyperacetylated Chromatin Domains Mark Cell Type-Specific Genes and Suggest Distinct Modes of Enhancer Function
Hyperacetylated Chromatin Domains Mark Cell Type-Specific Genes and Suggest Distinct Modes of Enhancer Function Open
Stratification of enhancers by relative signal strength in ChIP-seq assays has resulted in the establishment of super-enhancers as a widespread and useful tool for identifying cell type-specific, highly expressed genes and associated pathw…
View article: Erythropoietin Signaling Regulates Key Epigenetic and Transcription Networks in Fetal Neural Progenitor Cells
Erythropoietin Signaling Regulates Key Epigenetic and Transcription Networks in Fetal Neural Progenitor Cells Open
Erythropoietin (EPO) and its receptor are highly expressed in the developing nervous system, and exogenous EPO therapy is potentially neuroprotective, however the epigenetic and transcriptional changes downstream of EPO signaling in neural…
View article: Histone Methyltransferase Setd8 Represses Gata2 Expression and Regulates Erythroid Maturation
Histone Methyltransferase Setd8 Represses Gata2 Expression and Regulates Erythroid Maturation Open
Setd8 is the sole histone methyltransferase in mammals capable of monomethylating histone H4 lysine 20 (H4K20me1). Setd8 is expressed at significantly higher levels in erythroid cells than any other cell or tissue type, suggesting that Set…